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Limitations and Advantages of Meta-analysis in Clinical Trials

  • Conference paper

Part of the Recent Results in Cancer Research book series (RECENTCANCER,volume 111)


Meta-analysis has recently been applied to a variety of areas in medical research (Collins and Langman 1985; Himel et al. 1986; Collins et al. 1985; Tran and Welt- man 1985). By meta-analysis we mean a quantitative synthesis of data across several different but related studies. This usually entails the application of uniform methods of statistical analyses and/or data presentation. Reasons for performing a meta-analysis include confirmation of a general hypothesis by combining data from related studies, estimation of a general treatment effect by combining data from related studies, generation of hypotheses for further testing, and convincing others of a finding by presenting a systematic summary of all studies related to that finding.


  • Average Treatment Effect
  • Classical Hypothesis
  • Public Health Decision
  • Systematic Summary
  • Adjuvant Therapy Trial

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

The research was partially supported by the National Cancer Institute, U10CA 12027, and by American Cancer Society grant RC13.

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  • Begg CB (1985) A measure to aid in the interpretation of published clinical trials. Stat Med 4:1–9

    CrossRef  PubMed  CAS  Google Scholar 

  • Byar D (1985) Assessing apparent treatment-covariate interactions in randomized clinical trials. Stat Med 4: 255–263

    CrossRef  PubMed  CAS  Google Scholar 

  • Collins R, Langman M (1985) Treatment with histamine-H antagonists in acute upper gastrointestinal hemorrhage. N Engl J Med 313: 659–666

    CrossRef  Google Scholar 

  • Collins R, Yusuf S, Peto R (1985) Overview of randomized trials of diuretics in pregnancy. B Med J 290: 17–22

    CrossRef  CAS  Google Scholar 

  • DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Controlled Clin Trials 7: 177–188

    CrossRef  Google Scholar 

  • Gelber RD, Goldhirsch A (1986) The concept of an overview of cancer clinical trials with special emphasis on early breast cancer. J Clin Oncol 4(11): 1696–1703

    PubMed  CAS  Google Scholar 

  • Green S, Byar D (1980) Using observational data from registries to compare treatments: the fallacy of omnimetrics. Stat Med 3: 361–370

    CrossRef  Google Scholar 

  • Greenwald AG (1975) Consequences of prejudice against the null hypothesis. Psychol Bull 82: 1–20

    CrossRef  Google Scholar 

  • Himel HN, Liberati AL, Gelber RD, Chalmers TC (1986) Adjuvant chemotherapy for breast cancer: a pooled estimate based on published randomized control trials. JAMA 256:1148–1159

    CrossRef  PubMed  CAS  Google Scholar 

  • Light RJ, Pillemer DB (1984) Summing up: the science of reviewing research. Harvard University Press, Cambridge MA

    Google Scholar 

  • National Institutes of Health (1985) Adjuvant chemotherapy for breast cancer. NIH consensus development conference statement, vol 5, no 12. NIH consensus development conference, September 1985, Bethesda, Maryland

    Google Scholar 

  • Pocock SJ (1984) Clinical trials: a practical approach. Wiley, New York

    Google Scholar 

  • Tran ZV, Weltman A (1985) Differential effects of exercise on serum lipid and lipoprotein levels seen with changes in body weight: a meta-analysis. JAMA 254: 919–924

    CrossRef  PubMed  CAS  Google Scholar 

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© 1988 Springer-Verlag Berlin · Heidelberg

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Rockette, H.E., Redmond, C.K. (1988). Limitations and Advantages of Meta-analysis in Clinical Trials. In: Scheurlen, H., Kay, R., Baum, M. (eds) Cancer Clinical Trials. Recent Results in Cancer Research, vol 111. Springer, Berlin, Heidelberg.

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83421-9

  • Online ISBN: 978-3-642-83419-6

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