Limitations and Advantages of Meta-analysis in Clinical Trials
- 80 Downloads
Meta-analysis has recently been applied to a variety of areas in medical research (Collins and Langman 1985; Himel et al. 1986; Collins et al. 1985; Tran and Welt- man 1985). By meta-analysis we mean a quantitative synthesis of data across several different but related studies. This usually entails the application of uniform methods of statistical analyses and/or data presentation. Reasons for performing a meta-analysis include confirmation of a general hypothesis by combining data from related studies, estimation of a general treatment effect by combining data from related studies, generation of hypotheses for further testing, and convincing others of a finding by presenting a systematic summary of all studies related to that finding.
KeywordsAverage Treatment Effect Classical Hypothesis Public Health Decision Systematic Summary Adjuvant Therapy Trial
Unable to display preview. Download preview PDF.
- Light RJ, Pillemer DB (1984) Summing up: the science of reviewing research. Harvard University Press, Cambridge MAGoogle Scholar
- National Institutes of Health (1985) Adjuvant chemotherapy for breast cancer. NIH consensus development conference statement, vol 5, no 12. NIH consensus development conference, September 1985, Bethesda, MarylandGoogle Scholar
- Pocock SJ (1984) Clinical trials: a practical approach. Wiley, New YorkGoogle Scholar