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Update 1988 pp 693-698 | Cite as

Anticoagulation for Extracorporeal System

  • M. E. Sinclair
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 5)

Abstract

Blood, in the intact organism, is kept in a fluid state by the maintainance of an adequate blood flow, and rapid hepatic clearance of the coagulation factors following activation and fibrinolysis. There are also circulating serine protease inhibitors, such as antithrombin III (AT III), that prevent the spontaneous activation of certain factors in the coagulation cascade. During extracorporeal circulation, such as hemodialysis or cardiopulmonary bypass, the intrinsic pathway of the coagulation cascade is activated by the contact of the blood with a “foreign surface”. Once the cascade has been activated, it is necessary to use some form of anticoagulation to prevent clotting in the extracorporeal circuit.

Keywords

Coagulation Cascade Contact Activation Extracorporeal Circulation Extracorporeal Circuit Systemic Anticoagulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • M. E. Sinclair

There are no affiliations available

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