Anticoagulation for Extracorporeal System
Blood, in the intact organism, is kept in a fluid state by the maintainance of an adequate blood flow, and rapid hepatic clearance of the coagulation factors following activation and fibrinolysis. There are also circulating serine protease inhibitors, such as antithrombin III (AT III), that prevent the spontaneous activation of certain factors in the coagulation cascade. During extracorporeal circulation, such as hemodialysis or cardiopulmonary bypass, the intrinsic pathway of the coagulation cascade is activated by the contact of the blood with a “foreign surface”. Once the cascade has been activated, it is necessary to use some form of anticoagulation to prevent clotting in the extracorporeal circuit.
KeywordsDioxide Filtration Heparin Fractionation Serine
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