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Dopamine Agonists in Intensive Care Medicine: From Receptors to Clinical Applications

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Update 1988

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 5))

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Abstract

Dopamine is one of the most commonly used drugs in intensive care medicine. The catecholamine has multiple clinical applications because of its diverse pharmacological effects resulting from activation of several different receptors [1, 2]. More recently, new compounds have been investigated with different spectra of receptor activity and clinical applications than dopamine. The purpose of this chapter is to review the pharmacological effects of dopamine and other drugs acting on dopamine receptors and to summarize current and potential clinical applications in critical care medicine.

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References

  1. Goldberg LI (1972) Cardiovcascular and renal actions of dopamine: Potential clinical applications. Pharmacol Rev 241:1–29.

    Google Scholar 

  2. Goldberg LI, Rajfer SI (1985) Applications in clinical cardiology. Circulation 72:245–248.

    Article  CAS  PubMed  Google Scholar 

  3. Beregovich J, Bianchi C, Rubier S, Lomnitz E, Cagin N, Levitt B (1974) Dose-related hemodynamic and renal effects of dopamine in congestive heart failure. Am Heart J 87:550–557.

    Article  CAS  PubMed  Google Scholar 

  4. Levinson PD, Goldstein DS, Munson PJ, Gill JR Jr, Keiser HR (1985) Endocrine, renal, and hemodynamic responses to graded dopamine infusions in normal men. J Clin Endocrin Metab 60:821–826.

    Article  CAS  Google Scholar 

  5. D’Orio V, El Allaf D, Juchmes J, Marcelle R (1986) The use of low doses of dopamine in intensive care medicine. Arch Int Physiol Biochim 92:S11–S20.

    Article  Google Scholar 

  6. Goldberg LI, Volkman PH, Kohli JD (1978) A comparison of the vascular dopamine receptor with other dopamine receptors. Ann Rev Pharmacol Toxicol 18:57–79.

    Article  CAS  Google Scholar 

  7. Goldberg LI, Kohli JD (1983) Differentiation of dopamine receptors in the periphery. In: Kaiser C, Kebabian JW (eds) In: Dopamine Receptors. Amer Chem Soc Symposium Series #224, pp 101-113.

    Google Scholar 

  8. Felder RA, Blecher M, Calcagno PL, Jose PA (1984) Dopamine receptors in trhe proximal tubule of the rabbit. Am J Physiol 247:F499–F505.

    CAS  PubMed  Google Scholar 

  9. Bello-Reuss E, Higashi Y, Kanega Y (1982) Dopamine decreases fluid reabsorption in straight portions of rabbit proximal tubule. Am J Physiol 242:F634–F640.

    CAS  PubMed  Google Scholar 

  10. Hilberman M, Maseda J, Stinson EB, et al (1984) The diuretic properties of dopamine in patients after open-heart operation. Anesthesiology 61:489–494.

    Article  CAS  PubMed  Google Scholar 

  11. Parker S, Carlon GC, Isaacs M, Howland WS, Kahn RC (1981) Dopamine administration in oliguria and oliguric renal failure. Crit Care Med 9:630–632.

    Article  CAS  PubMed  Google Scholar 

  12. McDonald RH Jr, Goldberg LI, McNay JL, Tuttle EP (1964) Effects of dopamine in man: Augmentation of sodium excretion, glomerular filtration rate and renal plasma flow. J Clin Invest 43:1116–1124.

    Article  CAS  PubMed  Google Scholar 

  13. MacCannell KL, McNay JL, Meyer MB, Goldberg LI (1966) The use of dopamine in the treatment of hypotension and shock. New Eng J Med 275:1389–1398.

    Article  CAS  PubMed  Google Scholar 

  14. Horwitz D, Fox SM, Goldberg LI (1962) Effects of dopamine in man. Circ Res 10:237–243.

    CAS  PubMed  Google Scholar 

  15. Henderson IS, Beattie TJ, Kennedy AC (1980) Dopamine hydrochloride in oliguric states. Lancet 2:827–828.

    Article  CAS  PubMed  Google Scholar 

  16. Lindner A (1983) Synergism of dopamine and furosemide in diuretic-resistant, oliguric acute renal failure. Nephron 33:121–126.

    Article  CAS  PubMed  Google Scholar 

  17. Mann HJ, Fuhs DW, Hemstrom CA (1986) Acute renal failure. Drug Intelligence and Clinical Pharmacy 20:421–438.

    CAS  PubMed  Google Scholar 

  18. Miller RR, Awan NA, Joye JA, et al (1977) Combined dopamine and nitroprusside therapy in congestive heart failure. Circulation 55:881–884.

    CAS  PubMed  Google Scholar 

  19. Keung EC, Ribner HS, Schwartz W, Sonnenblick EH, LeJemtel TH (1980) Effects of combined dopamine and nitroprusside therapy in patients with severe pump failure and hypotension complicating acute myocardial infarction. J Cardiovasc Pharmacol 2:113–119.

    Article  CAS  PubMed  Google Scholar 

  20. Loeb HS, Ostrenga JP, Gaul W, et al (1983) Beneficial effects of dopamine combined with intravenous nitroglycerin on hemodynamics in patients with severe left ventricular failure. Circulation 68:813–820.

    Article  CAS  PubMed  Google Scholar 

  21. Richard C, Ricome JL, Rimailho JA, Bottineau G, Auzepy P (1983) Combined hemodynamic effects of dopamine and dobutamine in cardiogenic shock. Circulation 67:620–626.

    Article  CAS  PubMed  Google Scholar 

  22. Schaer GL, Fink MP, Parrillo JE (1985) Norepinephrine alone versus norepinephrine plus low-dose dopamine: Enhanced renal blood flow with combination pressor therapy. Crit Care Med 13:492–496.

    Article  CAS  PubMed  Google Scholar 

  23. Goldberg LI, Hsieh YY, Resnekov L (1977) Newer catecholamines for treatment of heart failure and shock. An update on dopamine and a first look at dobutamine. Prog Cardiovasc Dis 4:327–340.

    Article  Google Scholar 

  24. Rajfer SI, Anton AH, Rossen J, Goldberg LI (1984) Beneficial hemodynamic effects of oral levodopa in heart failure: Relationship to the generation of dopamine. Engl J Med 310:1357–1362.

    Article  CAS  Google Scholar 

  25. Fennell WH, Taylor AA, Young JB, et al (1983) Propylbutyldopamine: hemodynamic effects in conscious dogs, normal human volunteers, and patients with heart failure. Circulation 67:829–836.

    Article  CAS  PubMed  Google Scholar 

  26. Taylor AA, Fennell WH, Feldman MB, Brandon TA, Ginos JZ, Mitchell JR (1983) Activation of peripheral dopamine presynaptic receptors lowers blood pressure and heart rate in dogs. Hypertension 5:226–234.

    CAS  PubMed  Google Scholar 

  27. Brown RA, Dixon J, Farmer JB, et al (1985) Dopexamine: A novel agonist at peripheral dopamine receptors and beta2-adrenoceptors. Br J Pharmacol 85:599–608.

    CAS  PubMed  Google Scholar 

  28. Brown RA, Farmer JB, Hall JC, Humphries RQ, O’Connor SE, Smith GW (1985) The effects of dopexamine on the cardiovasclar system of the dog. Br J Pharmacol 85:609–619.

    CAS  PubMed  Google Scholar 

  29. Dawson JR, Thompson DS, Signy M, et al (1985) Acute haemodynamic and metabolic effects of dopexamine, a new dopaminergic receptor agonist, in patients with chronic heart failure. Br Heart J 54:313–320.

    Article  CAS  PubMed  Google Scholar 

  30. Svensson G, Sjogren A, Erhardt L (1986) Short-term haemodynamic effects of dopexamine in patients with chronic congestive heart failure. Eur Heart J 7:697–703.

    CAS  PubMed  Google Scholar 

  31. Colardyn F, Clement DL (1986) Acute and long-term haemodynamic effects of dopexamine hydrochloride in patients with chronic cardiac failure. Abstracts of X World Congress of Cardiology, Washington, DC, September, p 346 # 1980.

    Google Scholar 

  32. Jackson N, Frais M, Sharma SK, Reynolds G, Taylor SH (1986) A dose response haemodynamic study of dopexamine vs dopamine in ischaemic left ventricular failure. Abstract of X World Congress of Cardiology, Washington, DC, September, p 400 #2302.

    Google Scholar 

  33. Bonnier JJRM (1986) Dopexamine hydrochloride, haemodynamic effects in haemochronic cardiac failure, a comparison with dobutamine. Abstracts of X World Congress of Cardiology, Washington, DC, September, p 188 #1076.

    Google Scholar 

  34. Fung AY, Lal P, Pitt B, Walton JA Jr (1986) Acute hemodynamic effects of dopexamine in patients with congestive heart failure. Abstracts of X World Congress of Cardiology, Washington, DC, September, p 188 # 1074.

    Google Scholar 

  35. Jaski BE, Wijns W, Foulds R, Serruys PW (1986) The haemodynamic and myocardial effects of dopexamine: A new beta2-adrenoceptor and dopaminergic agonist. Brit J Clin Pharmacol 21:393–400.

    CAS  Google Scholar 

  36. Tan LB, Littler WA, Murray G (1987) Beneficial haemodynamic effects of intravenous dopexamine in patients with low-output heart failure. J Cardiovasc Pharmacol 10:280–286.

    Article  CAS  PubMed  Google Scholar 

  37. Bass AS, Kohli JD, Lubbers N, Goldberg LI (1987) Mechanisms mediating the positive inotropic and chronotropic changes induced by dopexamine in the anesthetized dog. J Pharmacol Exp Ther 242:940–944.

    CAS  PubMed  Google Scholar 

  38. Foulds RA, Magrini F, Zanchetti A (1986) The renovascular effects of dopexamine hydrochloride, a dopaminergic and beta2 adrenergic agonist. Abstracts of X World Congress on Cardiology, Washington, DC, September, p 201 #1151.

    Google Scholar 

  39. Tan LB, Smith SA, Murray RG, Littler WA (1986) Renal response to dopexamine infusion in low output heart failure. Clin Sci 71 (Suppl 15):56P # 155.

    Google Scholar 

  40. Carey RM, Stote RM, Dubb JW, Townsend LW, Rose CE Jr, Kaiser DL (1984) Selective peripheral dopamine-1 receptor stimulation with fenoldopam in human essential hypertension. J Clin Invest 74:2198–2207.

    Article  CAS  PubMed  Google Scholar 

  41. Ventura HO, Messerli FH, Frohlich ED, et al (1984) Immediate hemodynamic effects of a dopamine-receptor agonist (fenoldopam) in patients with essential hypertension. Circulation 69:1142–1145.

    Article  CAS  PubMed  Google Scholar 

  42. Murphy MB, McCoy CE, Weber RR, Frederickson ED, Douglas FL, Goldberg LI (1987) Augmentation of renal blood flow and sodium excretion in hypertensive patients during blood pressure reduction by intravenous administration of the dopamine1 agonist, fenoldopam. Circulation 76:1312–1318.

    Article  CAS  PubMed  Google Scholar 

  43. Young JB, Leon CA, Pratt CM, Suarez JM, Aronoff RD, Roberts R (1985) Hemodynamic effects of an oral dopamine receptor agonist (fenoldopam) in patients with congestive heart failure. J Am Coll Cardiol 6:792–796.

    Article  CAS  PubMed  Google Scholar 

  44. Lass NA, Goldberg LI, Lubbers N, Glock D (1986) Cardiac and renal vascular effects of the selective DA1 agonist, fenoldopam, alone and combined with dobutamine. Clin Res 34:638A.

    Google Scholar 

  45. Lass NA, Bakris GL, Glock D, Goldberg LI (1987) Alpha-adrenoceptor contribution to renal vascular effects of low-dose dopamine. Clin Res 35:644A.

    Google Scholar 

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© 1988 Springer-Verlag Berlin Heidelberg

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Goldberg, L.I. (1988). Dopamine Agonists in Intensive Care Medicine: From Receptors to Clinical Applications. In: Vincent, J.L. (eds) Update 1988. Update in Intensive Care and Emergency Medicine, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83392-2_83

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  • DOI: https://doi.org/10.1007/978-3-642-83392-2_83

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-18981-7

  • Online ISBN: 978-3-642-83392-2

  • eBook Packages: Springer Book Archive

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