Abstract
Acute renal failure in a sick patient is principally a consequence of renal ischemia, with the renal tubule being most vulnerable. This ischemic injury results in “acute tubular necrosis” (ATN), a reversible condition, except when the ischemia is so profound that tubular infarction (“cortical necrosis”) occurs. While the cause of oliguria and ATN is relatively uncontroversial, the mechanism by which these are sustained is less clear. However, for the purpose of this chapter we are principally concerned with measures which will prevent or minimize acute renal failure, and so require an understanding of the mechanisms leading to ATN.
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© 1988 Springer-Verlag Berlin Heidelberg
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Neild, G.H. (1988). Role of Endothelial Injury in the Pathogenesis of Acute Renal Failure. In: Vincent, J.L. (eds) Update 1988. Update in Intensive Care and Emergency Medicine, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83392-2_80
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DOI: https://doi.org/10.1007/978-3-642-83392-2_80
Publisher Name: Springer, Berlin, Heidelberg
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