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Role of Arachidonic Acid Metabolism in ARDS

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Update 1988

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 5))

Abstract

Arachidonic acid (AA), an unsaturated fatty acid directly from the diet or indirectly from the metabolism of linoleic acid, is released from the breakdown of cell membrane phospholipids by the action of the enzyme phospholipase A2. Numerous stimuli, ranging from simple mechanical to specific chemical stimulation may activate what has been named the arachidonic acid cascade. Phospholipase A2 itself can be inhibited by corticosteroids and local anesthetics which therefore are able to modulate the generation of AA.

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Authors
  1. D. R. Morel
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Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean Louis Vincent (Assistant-Director) (Assistant-Director)

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© 1988 Springer-Verlag Berlin Heidelberg

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Morel, D.R. (1988). Role of Arachidonic Acid Metabolism in ARDS. In: Vincent, J.L. (eds) Update 1988. Update in Intensive Care and Emergency Medicine, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83392-2_16

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  • DOI: https://doi.org/10.1007/978-3-642-83392-2_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-18981-7

  • Online ISBN: 978-3-642-83392-2

  • eBook Packages: Springer Book Archive

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