Paraneoplasias of the Skin

  • G. Niebauer
Conference paper


Four processes characterize a malignant neoplasm (Fig. 1).
  1. 1

    Autonomous local cell growth; the tumor cell becomes “correlation deaf”, owing to loss of inhibitory regulators.

  2. 2

    Tumor cell spread; penetration and metastases, the main indication of malignancy, caused by a large amount of enzyme activity, prostaglandins, etc.

  3. 3

    Pathologic products of metabolism that lead to the production of hormone-type communication.

  4. 4

    Host defence mechanisms that come into being mainly by immunologic processes (immune response). This means that a great variety of biochemical, immunologic and other reactions can be shown in every malignant process.



Bullous Pemphigoid Acanthosis Nigricans Epidermal Proliferation Visceral Malignancy Visceral Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • G. Niebauer
    • 1
  1. 1.Department of Dermatology IIUniversity of ViennaViennaAustria

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