Advertisement

Systemic Mycosis

  • E. Solano Aquilar
  • R. Negroni
  • W. Meinhof
  • A. Padilha-Gonçalves
  • D. Pappagianis
  • K. Iwata
  • A. González Mendoza
  • J. R. Graybill
Conference paper

Abstract

The systemic mycoses form a group of diseases which are difficult to diagnose and treat. They attack the human organism, selecting sometimes the lung tissue as in coccidioidomycosis, in histoplasmosis etc., or spread through the blood stream attacking the central nervous system, the gastrointestinal tract, the circulatory system, the eyes, the bones, the joints, the skin, provoking fatal consequences for the patient, as in systemic candidiasis.

Keywords

Invasive Aspergillosis Neutropenic Patient Systemic Mycosis Febrile Neutropenic Patient Opportunistic Mycosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Lutz A (1908) Una mycose pseudococcidica localizada na boca e observada no Brasil. Contribuiçao ao estudo das hyphoblastomycoses americanas. Brasil-méd 22:121–124/141-144.Google Scholar
  2. 2.
    Paracoccidioidomycosis — Proceedings of the First Pan American Symposium (1972) Scientific Publication 254, Pan American Health Organization, Washington.Google Scholar
  3. 3.
    Negroni P (1966) El Paracoccidioides brasiliensis vive saprofiticamente en el suelo argentino. Prensa-med argent 53:2381–2382.PubMedGoogle Scholar
  4. 4.
    Albornoz MB (1971) Isolation of Paracoccidioides brasiliensis from rural soil in Venezuela. Sabourandia 9:248–253.CrossRefGoogle Scholar
  5. 5.
    Grose E, Tamsitt JR (1965) Paracoccidioides brasiliensis recovered from the intestinal tract of three bats (Artibeus lituratus) in Colombia S.A. Sabouraudia 4:124–125.PubMedCrossRefGoogle Scholar
  6. 6.
    Johnson WD, Lang CM (1977) Paracoccidioidomycosis (South American blastomycosis) in a squirrel monkey (Saimiri sciureus). Vet Path 14:363–371.Google Scholar
  7. 7.
    Naiff RD, Ferreira LCL, Barrett TV, Naiff MF, Arias JR (1986) Paracoccidioidomicose enzoôtica em tatus (Dasypus novemcinctus) no Estado do Para. Rev Inst Med Trop São Paulo 28:19–27.PubMedCrossRefGoogle Scholar
  8. 8.
    Fava Netto C, Martins-Castro R, Padilha-Gonçalves A, Dillon NL (1965) Ocorrência familiar da blastomicose sul-americana. Rev Inst Med Trop São Paulo 7:332–336.Google Scholar
  9. 9.
    Gonzalez-Ochoa A (1956) Classificatión clinica de las micosis. Rev Inst Salubr Enf Trop (Mex) 16:1–8.Google Scholar
  10. 10.
    Moraes, CR, Fiorillo AM, Costa JC (1967) Lesões radiológicas intestinais na blastomicose sul-americana. Hospital (Rio de Janeiro) 71:733–744.Google Scholar
  11. 11.
    Fonseca LC, Mignone C (1976) Paracoccidioidomicose do intestino delgado. Aspectos anatomoclinicos e radiológicos de 125 casos. Rev Hosp Clin Fac Med S. Paulo 31:199–207.PubMedGoogle Scholar
  12. 12.
    Martinez R, Meneghelli VG, Dantas RO, Fiorillo AM (1979) O comprometimento gastrintestinal na blastomicose sul-americana (paracoccidioidomicose). I. Estudo clinico, radiológico e histopatológico. Rev Ass Med Brasil 25:31–34.Google Scholar
  13. 13.
    Brito T, Carvalho RPS, Martins Castro R, Furtado JS (1972) Pathogenesis of experimental Paracoccidioidomycosis. Paracoccidioidomycosis, Proc First Pan Am Symposium Scientific Pub 254, PAHO, Washington, pp 257–260.Google Scholar
  14. 14.
    Grimaldi de Jimenez G, Yegres F, San-Blás F (1979) Liberation of protoplasts from the yeast-like form of Paracoccidioides brasiliensis by enzymatic treatment. Sabouraudia 17:279–285.CrossRefGoogle Scholar
  15. 15.
    Teixeira GA, Machado Filho J, Miranda JL (1985) Blastomicose sul-americana experimental. Estudo experimental em ratos com considerações relativas à patogenia das lesões. Hospital (Rio de Janeiro) 68:1018–1096.Google Scholar
  16. 16.
    Padilha-Gonçalves A (1964) Sub-clinical adenopathy in Lutz mycosis. First congress of the international society of tropical dermatology, Nápoles, June, 8–13, 1964. Minerva Dermat 39 (suppl 1):32.Google Scholar
  17. 17.
    Padilha-Gonçalves A (1971) Adenopatia da micose de Lutz. Thesis to be Titular Professor of Dermatology, Rio de Janeiro, Copicentro-Rio.Google Scholar
  18. 18.
    Lacaz CS (1956) South American blastomycosis. An Fac Med Univ S. Paulo 29:2–120.Google Scholar
  19. 19.
    Fava Netto C (1976) Imunologica da paracoccidioidomicose. Rev Inst Med Trop São Paulo 18:42–53.PubMedGoogle Scholar
  20. 20.
    Yarzábal LA (1971) Anticuerpos precipitantes específicos de la blastomicosis sudamericana revelados por immunoelectroforesis. Rev Inst Med Trop Säo Paulo 13:320–327.PubMedGoogle Scholar
  21. 21.
    Yarzábal LA, Andrieu S, Bout D, Naquira F (1976) Isolation of a specific antigen with alkaline phosphatase activity from soluble extracts of Paracoccidioides brasiliensis. Sabouraudia 14:275–280.PubMedCrossRefGoogle Scholar
  22. 22.
    Puccia R, Schenkman S, Gorin PAJ, Travassos RL (1986) Exocellular components of Paracoccidioides brasiliensis: identification of a specific antigen. Infect Immun 53:199–206.PubMedGoogle Scholar
  23. 23.
    San-Blás G, San-Blás F, Serrano LE (1979) Host-parasite relationship in the yeast-like form of Paracoccidioides brasiliensis strain IVIC Pb9. Infect Immun 15:343–346.Google Scholar
  24. 24.
    Scroferneker ML, Fava Netto C, Schalch ALO (1983) Contribuiçao para o estudo da composiçao antigênica do Paracoccidioides brasiliensis. Anais do II Encontro sobre Paracoccidioidomicose, Botucatu, p 1.Google Scholar
  25. 25.
    Orsi S, Biagioni L, Sadatsune T Franco M (1983) Caracterização imunolôgica de amostras de P. brasiliensis isolades de pacientes de área endêmica de Botucatu. July 21–23, Botucatu, P2.Google Scholar
  26. 26.
    Padilha-Gonçalves A (1985) Paracoccidioidomicose. Atualidade. Classificação. An brasil dermatol 60 (supl l):271–280.Google Scholar
  27. 1.
    Ajello L, Kaufman L, Kaplan W, George L (1962) Laboratory manual for medical mycology. Communicable Disease Center, Atlanta, Georgia.Google Scholar
  28. 2.
    Alsip S, Dismukes WE (1986) Approach to the patient with suspected histoplasmosis. In: Remington JS, Swartz MN (eds) Current clinical topics in infectious diseases. MacGraw-Hill, New York, pp 254–296.Google Scholar
  29. 3.
    Arechavala A, Negroni (1978) Estado inmunitario de enfermos portadores de micosis sistemicas. Rev Arg Micol 1 (3):5–11.Google Scholar
  30. 4.
    Borelli D (1970) Prevalence of systemic mycosis in Latin América. In: International symposium on mycoses. PAIIO Scient Publ 205:28–38.Google Scholar
  31. 5.
    Conant NF, Smith DT, Baker RD et al. (1971) Manual of clinical mycology, 3rd edn. Saunders, London.Google Scholar
  32. 6.
    Chandler FW, Kaplan W, Ajello L (1980) A colour atlas and text book of the histopathology of mycotic diseases. Wolfe Medical, Lochern, The Netherlands.Google Scholar
  33. 7.
    Emmons ChW, Binford Ch, Utz JP (1977) Medical mycology. Lea and Febiger, Philadelphia.Google Scholar
  34. 8.
    Goodwin R, Loyd JE, Des Prez R (1981) Histoplasmosis in normal host. Medicine 60 (4):231–266.PubMedCrossRefGoogle Scholar
  35. 9.
    Goodwin RA, Shapiro JL et al. (1984) Disseminated histoplasmosis. Clinical and pathologic correlations. Medicine 59:1–33.Google Scholar
  36. 10.
    Larsh HW (1970) Ecology and epidemiology of histoplasmosis. Proc Intern Symp Mycoses. Pan Am Health Org 59-63.Google Scholar
  37. 11.
    Negroni P (1960) Micosis profundas, vol II Histoplasmosis, Comisión de Investigaciones Científicas de la Provincia de Buenos Aires.Google Scholar
  38. 12.
    Negroni R (1978) Manifestaciones cutáneas de 1a histoplasmosis. Rev Arg Micol 1 (1):5–16.Google Scholar
  39. 13.
    Negroni R (1976) Inmunología de las micosis sistémicas. Rev Asoc Arg Microb 8:117–127.Google Scholar
  40. 14.
    Negroni R (1980) Ketoconazole in the treatment of paracoccidioidomycosis and histoplasmosis. Vth Intern conf mycoses. Scientific Publication No 396. Pan Am Health Org.Google Scholar
  41. 15.
    Rubinstein P, Negroni R (1981) Micosis broncopulmonares del adulto y del niño, 2nd edn. Editorial Beta, S.R. Buenos Aires.Google Scholar
  42. 16.
    Sarosi GA, Davies SF (1982) Clinical manifestations and management of histoplasmosis in compromised patient. In: Warnock DIW, Richardson MD (eds) Fungal infection in the compromised patient, Wiley, Chichester, Chap. 7, pp 187–198.Google Scholar
  43. 17.
    Sarosi G, Davies SF (1984) Histoplasmosis. En Braude A. Enfermedades Infecciosas. Editorial Panamericana. Buenos Aires, pp 217–223.Google Scholar
  44. 18.
    Slam ThG (1983) Treatment of disseminated and progressive cavitary histoplasmosis with ketoconazole. Am J Med 78:70–73.CrossRefGoogle Scholar
  45. 1.
    Dismukes WE, Stamm AM, Graybill JR et al. (1983) Treatment of systemic mycoses with ketoconazole: emphasis on toxicity and clinical response in 52 patients. Ann Int Med 98:13–20.PubMedCrossRefGoogle Scholar
  46. 2.
    McManus EJ, Jones JM (1986) The use of ketoconazole in the treatment of blastomycosis. Am Rev Resp Dis 133:141–143.PubMedGoogle Scholar
  47. 3.
    Bradsher RW, Rice DC, Abernathy RS (1985) Ketoconazole therapy for blastomycosis. Ann Int Med 103:872–879.PubMedCrossRefGoogle Scholar
  48. 4.
    NIAID Mycoses Study Group (1985) Treatment of blastomycosis and histoplasmosis with ketoconazole. Ann Int Med 103:861–872.CrossRefGoogle Scholar
  49. 5.
    Dismukes WD, Bradsher R, Girard W et al. (1986) Itraconazole therapy for blastomycosis and histoplasmosis. 26th Interscience Conference on antimicrobial agents and chemotherapy, abstract 798.Google Scholar
  50. 6.
    Philips JR, Jones S, Adamson JS et al. (1972) Long-term follow-up of 101 patients with blastomycosis. Am Rev Resp Dis 105:1006–1007.Google Scholar
  51. 7.
    Hawkins SS, Gregory DW, Alford RH (1981) Progressive disseminated histoplasmosis: favorable response to ketoconazole. Ann Int Med 95:446–449.PubMedCrossRefGoogle Scholar
  52. 8.
    Drouhet E, DuPonte B (1983) Laboratory and clinical assessment of ketoconazole in deep seated mycoses. Am J Med 74 (S):30–47.PubMedCrossRefGoogle Scholar
  53. 9.
    Slama TG (1983) Treatment of disseminated and progressive cavitary histoplasmosis with ketoconazole. Am J Med 74 (S):70–73.PubMedCrossRefGoogle Scholar
  54. 10.
    Negroni R, Palmieri O, Koren K et al. (1987) Oral treatment of paracoccidioidomycosis and histoplasmosis with itraconazole in humans. Rev Inf Dis 9 (S):S47–S50.CrossRefGoogle Scholar
  55. 11.
    Reddy P, Gorelick DF, Brasher CA et al. (1970) Progressive disseminated histoplasmosis as seen in adults. Am J Med 48:629–636.PubMedCrossRefGoogle Scholar
  56. 12.
    Parker JD, Sarosi GA, Doto IL, Bailey RE, Tosh FE (1970) Treatment of chronic pulmonary histoplasmosis: a National Communicable Disease Control cooperative mycoses study. N Engl J Med 283:225–229.PubMedCrossRefGoogle Scholar
  57. 13.
    Wheat LJ, Small CB (1984) Disseminated histoplasmosis in the acquired immune deficiency syndrome. Arch Int Med 144:2147–2149.CrossRefGoogle Scholar
  58. 14.
    Graybill JR, Lundberg D, Donovan W et al. (1980) Treatment of coccidioidomycosis with ketoconazole: clinical and laboratory studies of 18 patients. Rev Inf Dis 2:661–673.CrossRefGoogle Scholar
  59. 15.
    DeFelice R, Galgiani JN, Campbell SC et al. (1982) Ketoconazole therapy of nonprimary coccidioidomycosis: evaluation of 60 patients during three years of study. Am J Med 72:681–687.PubMedCrossRefGoogle Scholar
  60. 16.
    Stevens DA, Stiller RL, Williams PL (1983) Experience with ketoconazole in three major manifestations of progressive coccidioidomycosis. Am J Med 74(S):58–63.PubMedCrossRefGoogle Scholar
  61. 17.
    Graybill JR, Galgiani J, Stevens D et al. (1986) Progress in treatment of systemic mycoses: recent trials of the Mycoses Study Group. In Iwata K, Vanden Bossche H (eds) in vitro and in vivo evaluation of antifungal agents. Elsevier, Amsterdam, pp 247–256.Google Scholar
  62. 18.
    Graybill JR, Stevens DA, Galgiani JN et al. (1986) Itraconazole therapy of coccidioidomycosis. Twenty Sixth Interscience Conference on Antimicrobial Agents and Chemotherapy, Abstract 788.Google Scholar
  63. 19.
    Restrepo A, Gomez I, Cano L et al. (1983) Treatment of paracoccidioidomycosis with ketoconazole: a three-year experience. Am J Med 74(S):48–52.PubMedCrossRefGoogle Scholar
  64. 20.
    Restrepo A, Gomez I, Cano L et al. (1983) Post-therapy status of paracoccidioidomycosis treated with ketoconazole. Am J Med 74(S):53–57.PubMedGoogle Scholar
  65. 21.
    Restrepo A, Gomez I, Robledo J et al. (1987) Itraconazole in the treatment of paracoccidioidomycosis: a preliminary report. Rev Inf Dis 9(S):S51–S56.CrossRefGoogle Scholar
  66. 22.
    Zuger A, Louie E, Holzman S et al. (1986) Cryptococcal disease in patients with the acquired immunodeficiency syndrome. Ann Int Med 104:234–240.PubMedCrossRefGoogle Scholar
  67. 23.
    Kovacs JA, Kovacs AA, Polis M et al. (1985) Cryptococcosis in the acquired immunodeficiency syndrome. Ann Int Med 103:533–538.PubMedCrossRefGoogle Scholar
  68. 24.
    Gershon SL, Talbot GH, Hurwitz S et al. (1985) Discriminant scorecard for diagnosis of invasive pulmonary aspergillosis in patients with acute leukemia. Am J Med 79:57–64.CrossRefGoogle Scholar
  69. 25.
    Parfrey NA (1986) Improved diagnosis and prognosis of mucormycosis. Medicine 65:113–123.PubMedCrossRefGoogle Scholar
  70. 26.
    Berkowitz ID, Robboy SJ, Karchmer AW et al. (1979) Torulopsis glabrata fungemia — a clinicopathologic study. Medicine 58:430–440.PubMedCrossRefGoogle Scholar
  71. 27.
    Hoy J, Hsu K-C, Rolston K et al. (1986) Trichosporon beigelii: a review. Rev Inf Dis 8:959–967.CrossRefGoogle Scholar
  72. 28.
    Jameson B, Carter RL, Watson JG et al. (1981) An unexpected fungal infection in a patient with leukemia. J Clin Pathol 34:267–270.PubMedCrossRefGoogle Scholar
  73. 29.
    Meunier-Carpentier F, Cruciani M, Klastersky J (1983) Oral prophylaxis with miconazole or ketoconazole of invasive fungal disease in neutropenic cancer patients. Eur J Clin Oncol 19:43–48.CrossRefGoogle Scholar
  74. 30.
    Jones PG, Kaufman C, McAuliffe LS et al. (1984) Efficacy of ketoconazole vs nystatin in prevention of fungal infections in neutropenic patients. Arch Int Med 144:549–551.CrossRefGoogle Scholar
  75. 31.
    Hann IM, Corringham R, Keaney M et al. (1982) Ketoconazole versus nystatin plus amphotericin B for fungal prophylaxis in severely immunocompromised patients. Lancet I:826–829.CrossRefGoogle Scholar
  76. 32.
    Meunier-Carpentier F (1984) Chemoprophylaxis of fungal infections. Am J Med 76:652–656.PubMedCrossRefGoogle Scholar
  77. 33.
    Tricot G, Joosten E, Boogaerts MA et al. (1987) Ketoconazole vs itraconazole for antifungal prophylaxis in patients with severe granulocytopenia: preliminary results, of two nonrandomized studies. Rev Inf Dis 9(S):S94–S99.CrossRefGoogle Scholar
  78. 34.
    Pizzo PA, Robichaud KJ, Gill FA et al. (1982) Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia. Am J Med 72:101–111.PubMedCrossRefGoogle Scholar
  79. 35.
    Meunier-Carpentier F, Kiehn T, Armstrong D (1981) Fungemia in the immunocompromised host: changing patterns, antigenemia, high mortality. Am J Med 71:363–370.PubMedCrossRefGoogle Scholar
  80. 36.
    Horn R, Wong B, Kiehn T (1985) Fungemia in a cancer hospital: changing frequency, earlier onset, and results of therapy. Rev Inf Dis 7:646–655.CrossRefGoogle Scholar
  81. 37.
    Fisher BD, Armstrong D, Yu B, Gold JWM (1981) Invasive aspergillosis: progress in early diagnosis and treatment. Am J Med 71:571–577.PubMedCrossRefGoogle Scholar
  82. 38.
    Burch PA, Karp JE, Merz WG et al. (1986) Favorable outcome of invasive aspergillosis (IA) in adult acute leukemia. Twenty-sixth Interscience Conference on Antimicrobial Agents and Chemotherapy, 1986, abstract 782.Google Scholar
  83. 39.
    Lopez-Berestein G, Fainstein V, Hopfer R et al. (1985) Liposomal amphotericin B for the treatment of systemic fungal infections in patients with cancer: a preliminary study. J Inf Dis 151:704–710.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • E. Solano Aquilar
    • 1
  • R. Negroni
    • 2
  • W. Meinhof
    • 3
  • A. Padilha-Gonçalves
    • 4
  • D. Pappagianis
    • 5
  • K. Iwata
    • 6
  • A. González Mendoza
    • 7
  • J. R. Graybill
    • 8
  1. 1.San JoseCosta Rica
  2. 2.Centro de Micologia, Facultad de MedicinaInstitute of MicrobiologyBuenos AiresArgentina
  3. 3.Department of DermatologyTechnical University AachenAachenFR Germany
  4. 4.University of Rio de JaneiroRio de JaneiroBrazil
  5. 5.Department of Medical Microbiology and ImmunologyUniversity of California School MedicineDavisUSA
  6. 6.Department of MicrobiologyKagawa Nutrition CollegeSaitama-kenJapan
  7. 7.Guadalajara CityMexico
  8. 8.Department of MedicineAudie Murphy Veterans Administration Hospital and the University of Texas Health Science CenterSan AntonioUSA

Personalised recommendations