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Lupus Erythematosus and Its Subsets

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Dermatology in Five Continents

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Summary

The clinical, histological, immunopathological, and serological manifestations of patients with a clinically distinctive form of cutaneous lupus erythematosus (LE), subacute cutaneous LE, are presented and contrasted to those of patients who have only discoid LE skin lesions. In addition, the clinical significance of autoantibodies to the Ro/SS-A cellular antigen, the serological marker of subacute cutaneous LE, is discussed. The results support our hypothesis that subacute cutaneous LE skin lesions can serve as a marker for a clinically and serologically discrete subset of LE patients whose overall illness is intermediate in severity between that of patients with discoid LE and active systemic LE.

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References

  1. Sontheimer RD, Thomas JR, Gilliam JN (1979) Subacute cutaneous lupus erythematosus: a cutaneous marker for a distinct lupus erythematosus subset. Arch Dermatol 115:1409.

    Article  PubMed  CAS  Google Scholar 

  2. Prystowsky SD, Gilliam JN (1975) Discoid lupus erythematosus as part of a larger disease spectrum. Correlation of clinical features with laboratory findings in lupus erythematosus. Arch Dermatol 11:1448.

    Article  Google Scholar 

  3. Prystowsky SD, Herndon JH, Gilliam JN (1975) Chronic cutaneous lupus erythematosus (DLE) — a clinical and laboratory investigation of 80 patients. Medicine 55:183.

    Article  Google Scholar 

  4. O’Loughlin S, Schroeter AL, Jordon RE (1978) A study of lupus erythematosus with particular reference to generalized discoid lupus. Br J Dermatol 99:1.

    Article  PubMed  Google Scholar 

  5. Millard LG, Rowell NR (1979) Abnormal laboratory test results and their relationship to prognosis in discoid lupus erythematosus. Arch Dermatol 115:1055.

    Article  PubMed  CAS  Google Scholar 

  6. Callen JP (1982) Chronic cutaneous lupus erythematosus. Clinical, laboratory, therapeutic and prognostic examination of 62 patients. Arch Dermatol 118:412.

    Article  PubMed  CAS  Google Scholar 

  7. Callen JP, Fowler JF, Kulick KB (1985) Serologic and clinical features of patients with discoid lupus erythematosus: relationship of antibodies to single stranded deoxyribonucleic acid and of other antinuclear antibody subsets to clinical manifestations. J Am Acad Dermatol 13:748.

    Article  PubMed  CAS  Google Scholar 

  8. Tan EM, Cohen AS, Fries JF et al. (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arth Rheum 25:1271.

    Article  CAS  Google Scholar 

  9. Levin RE, Weinstein A, Peterson M et al. (1984) A comparison of the sensitivity of the 1971 and 1982 American Rheumatism Association criteria for the classification of systemic lupus erythematosus. Arth Rheum 27:530.

    Article  CAS  Google Scholar 

  10. Sontheimer RD, Maddison PJ, Reichlin M et al. (1982) Serologic and HLA associations of subacute cutaneous lupus erythematosus, a clinical subset of lupus erythematosus. Ann Int Med 97:664.

    Article  PubMed  CAS  Google Scholar 

  11. David KM, Forten JC, Davis B et al. (1984) Morbidity and mortality in patients with subacute cutaneous lupus erythematosus. Clin Res 32:578 A.

    Google Scholar 

  12. Bangert J, Freeman R, Sontheimer RD et al. (1984) Subacute cutaneous lupus erythematosus and discoid lupus erythematosus. Comparative histopathologic findings. Arch Dermatol 120:332.

    Article  PubMed  CAS  Google Scholar 

  13. Kay DM, Tuffanelli DL (1969) Immunofluorescent techniques in clinical diagnosis of cutaneous disease. Ann Int Med 71:753.

    Article  PubMed  CAS  Google Scholar 

  14. Dahl MV (1983) Usefulness of direct immunofluorescence in patients with lupus erythematosus. Arch Dermatol 119:1010.

    Article  PubMed  CAS  Google Scholar 

  15. Weigand DA (1986) Lupus band test: anatomic regional variations in discoid lupus erythematosus. J Am Acad Dermatol 14:426.

    Article  PubMed  CAS  Google Scholar 

  16. Lieu T-S, Reimer CB, Sontheimer RD (to be published) Characterization of the autoimmune response to Ro/SS-A antigen in patients with subacute cutaneous lupus erythematosus by enzyme linked immunosorbent assay analysis. J Invest Dermatol.

    Google Scholar 

  17. Purcell SM, Lieu T-S, Davis BM et al. (to be published) Relationship between circulating anti-Ro/SS-A antibody levels in skin disease activity in subacute cutaneous lupus erythematosus. Br J Dermatol.

    Google Scholar 

  18. Sontheimer RD, Stastny P, Gilliam JN (1981) Human histocompatibility antigen associations in subacute cutaneous lupus erythematosus. J Clin Invest 67:312.

    Article  PubMed  CAS  Google Scholar 

  19. Millard LG, Rowell NR, Rajah SM (1977) Histocompatibility antigens in discoid and systemic lupus erythematosus. Br J Dermatol 96:139.

    Article  PubMed  CAS  Google Scholar 

  20. Fowler JF, Callen JP, Stelzer GT et al. (1985) Human histocompatibility antigen association in patients with chronic cutaneous lupus erythematosus. J Am Acad Dermatol 12:73.

    Article  PubMed  CAS  Google Scholar 

  21. Colaco CB, Elkon KB (1985) The lupus anticoagulant. A disease marker in antinuclear antibody negative lupus that is cross reactive with auto-antibodies to double-stranded DNA. Arthritis Rheum 28:67–74.

    Article  PubMed  CAS  Google Scholar 

  22. Colaco CB, Male DK (1985) Antiphospholipid antibodies in syphilis and a thrombotic subset of SLE. Distinct profiles of epitope specificity. Clin Exp Immunol 59:446–449.

    Google Scholar 

  23. Elias M, Eldor A (1984) Thromboembolism in patients with the “lupus” type circulating anticoagulant. Arch Intern Med 14:510–515.

    Article  Google Scholar 

  24. Gold JE, Haubenstock A, Zalusky R (1986) Lupus anticoagulant and AIDS. N Engl J Med 314:1252–1253.

    PubMed  CAS  Google Scholar 

  25. Grob JJ, Bonerandi JJ (1986) Cutaneous manifestations associated with the presence of the lupus anticoagulant. J Am Acad Dermatol 15:211–219.

    Article  PubMed  CAS  Google Scholar 

  26. Harris EN, Gharavi AE, Loizon S et al. (1985) Cross reactivity of antiphospholipid antibodies. J Clin Lab Immunol 16:1–6.

    PubMed  CAS  Google Scholar 

  27. Hughes GRV (1983) Thrombosis abortion, cerebral disease and the lupus anticoagulant. Br Med J 287:1088–1089.

    Article  CAS  Google Scholar 

  28. Lafer E, Rauch J, Andrezejewski C et al. (1981) Polyspecific monoclonal lupus antibodies reactive with both polynucleotides and phospholipids. J Exp Med 153:65–93.

    Article  Google Scholar 

  29. Lubbe WF, Pattison N, Liggins GC (1985) Antiphospholipids antibodies and pregnancy. N Engl J Med 21:1350–1351.

    Google Scholar 

  30. Soulier JP, Boffa MC (1980) Avortements à répétition, thromboses et anticoagulant circulant anti-thromboplastine. Nouv Presse Med 9:859–864.

    Google Scholar 

  31. LeFeber WP, Norris DA, Ryan SR et al. (1984) Ultraviolet light induces binding of antibodies to selected nuclear antigens on cultured human keratinocytes. J Clin Invest 74:1545–1551.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Health Science Center at Dallas, Southwestern Medical School, University of Texas, Dallas, Texas, USA

    R. D. Sontheimer (Chairman)

  2. Department of Dermatology, University of Strassburg, Strassburg, France

    E. Grosshans (Co-Chairman)

  3. Department of Dermatology, University of Bonn, Bonn, FR Germany

    H. W. Kreysel

  4. Department of Dermatology, Hospital St. Marguerite, Marseille, France

    J. J. Grob & J. J. Bonerandi

  5. Department of Dermatology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA

    R. Watson & T. T. Provost

  6. Department of Dermatology, Charité-Hospital, Humboldt-University, Berlin, GDR

    N. Sönnichsen

Authors
  1. R. D. Sontheimer
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  2. E. Grosshans
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  3. H. W. Kreysel
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  4. J. J. Grob
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  5. J. J. Bonerandi
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  6. R. Watson
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  7. T. T. Provost
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  8. N. Sönnichsen
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Editor information

Editors and Affiliations

  1. Universitäts-Hautklinik und Poliklinik, Klinikum Steglitz der Freien Universität, Hindenburgdamm 30, D-1000, Berlin 45, Federal Republic of Germany

    Constantin E. Orfanos (CMD — Scientific Secretariat), Rudolf Stadler (CMD — Scientific Secretariat) & Harald Gollnick (CMD — Scientific Secretariat) (CMD — Scientific Secretariat),  (CMD — Scientific Secretariat) &  (CMD — Scientific Secretariat)

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© 1988 Springer-Verlag Berlin Heidelberg

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Sontheimer, R.D. et al. (1988). Lupus Erythematosus and Its Subsets. In: Orfanos, C.E., Stadler, R., Gollnick, H. (eds) Dermatology in Five Continents. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83360-1_39

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  • DOI: https://doi.org/10.1007/978-3-642-83360-1_39

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83362-5

  • Online ISBN: 978-3-642-83360-1

  • eBook Packages: Springer Book Archive

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