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Is There a Role for Perioperative Adjuvant Cytotoxic Therapy in the Treatment of Early Breast Cancer?

  • J. Houghton
  • M. Baum
  • R. Nissen-Meyer
  • D. Riley
  • R. A. Hern
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 115)

Abstract

The use of perioperative adjuvant therapy in the treatment of breast cancer is not new; its history goes back to the mid-1960s when several groups experimented with the use of the then relatively new cytotoxic agents, giving them at about the same time as primary surgery. The conclusions drawn by the various authors show that controversy is not new to this field!

Keywords

Breast Cancer Early Breast Cancer Main Effect Analysis Overview Analysis Cancer Research Campaign 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Anonymous (1984) Review of mortality results in randomised trials in early breast cancer. Lancet II: 1035–1036Google Scholar
  2. Finney R (1971) Adjuvant chemotherapy in the radical treatment of carcinoma of the breast — a clinical trial. Am J Roentgenol III: 137–141Google Scholar
  3. Fisher B, Ravdin RG, Ausman RK, Slack NH, Moore GET; Noor RJ (1968) Surgical adjuvant chemotherapy in cancer of the breast; results of a decade of cooperative investigation. Ann Surg 168: 337–356PubMedCrossRefGoogle Scholar
  4. Fisher B, Slack N, Katryu D, Wolmark N (1975) Ten year follow-up of breast cancer patients in a cooperative clinical trial evaluating surgical adjuvant chemotherapy. Surg Gynecol Obstet 140: 528–534PubMedGoogle Scholar
  5. Goldhirsch A (1988) Early results of randomised perioperative therapy in operable breast cancer: the Ludwig Breast Cancer Study V, presented at 3rd international conference on adjuvant therapy of primary breast cancer.Google Scholar
  6. Mrazek RG, McDonald GO (1970) Surgery and adjuvant chemotherapy in treatment for breast carcinoma. Oncology — Proceedings of the tenth international cancer congress, Houston, Texas, p. 501Google Scholar
  7. Nissen-Meyer R (1979) Adjuvant cytostatic and endocrine therapy: increased cure rate or delayed manifest disease. In: Commentaries on research in breast disease 1. Liss, New York.Google Scholar
  8. Nissen-Meyer R, Kjellgren K, Mansson B (1971) Preliminary report from the Scandinavian adjuvant chemotherapy study group. Cancer Chemotherapy Reports 55: 561–566Google Scholar
  9. Nissen-Meyer R, Kjellgren K, Malmio K, Mansson B, Norm T (1978) Surgical adjuvant chemotherapy. Results with one short course with cyclophosphamide after mastectomy for breast cancer. Cancer 41: 2088–2098PubMedCrossRefGoogle Scholar
  10. Nissen-Meyer R, Host M, Kjellgren K, Mansson B, Norin T(1986) Treatment of node-negative breast cancer patients with short course of chemotherapy immediately after surgery. NCI Monogr 1: 125–134PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1989

Authors and Affiliations

  • J. Houghton
    • 1
  • M. Baum
    • 1
  • R. Nissen-Meyer
    • 2
  • D. Riley
    • 1
  • R. A. Hern
    • 1
  1. 1.CRC Clinical Trials CentreRayne InstitueLondonGreat Britain
  2. 2.Oslo 2Norway

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