Abstract
Campylobacter pylori (C. pylori) was rediscovered by Warren and Marshall in 1983 [1]. The presence of these bacilli on the gastric mucosa is closely associated with histologically demonstrable gastritis [2–6]. The number of bacteria appears related to the severity of gastritis. C. pylori colonises the gastric mucosa in almost 100% of patients with peptic ulcer disease, in 70% of the non-ulcer dyspepsia patients and in 20% of a group asymptomatic volunteers. Marshall and Warren hypothesized that C. pylori causes acute gastritis and achlorhydria, which in some patients progresses to chronic gastritis, dyspeptic symptoms and eventually ulceration. in some patients [7]. In order to determine whether C. pylori is aetiologically related to the gastric inflammatory changes, we have tried to eliminate the organisms by various therapeutic regimens and have studied the effect of these therapeutic attempts upon the gastric mucosa.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Warren JR, Marshall BJ (1983 ) Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet I:1273–1275
Marshall BJ, Warren JR (1984) Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet I:1311–1315
Meyrick Thomas J, Poynter D, Gooding C et al. (1984) Gastric spiral bacteria. Lancet II:100
McNulty CAM, Watson DM (1984 ) Spiral bacteria of the gastric antrum. Lancet I:1068–1069
Buck GE, Gourley WK, Lee WK et al. (1986) Relation of Campylobacter pyloridis to gastritis and peptic ulcer. J Inf Dis 153:664–669
Marshall BJ, McGechie OB, Rogers PA, Glanchy RJ (1985) Pyloric Campylobacter infection and gastroduodenal disease. Med J Austr 142:439–444
Marshall BJ, Armstrong JA, McGechie DB, Glancy RJ (1985) Attempt to fulfil Koch’s postulates for pyloric Campylobacter. Med J Austr 142:436–439
Goodwin CS, McCulloch RK, Armstrong JA et al. (1985)Unusual cellular fatty acids and distinctive ultrastructure in a new spiral bacterium (Campylobacter pyloridis) from the human gastric mucosa. J Med Microbiol 19:257–267
Pearson AD, Bamforth J, Booth L et al. (1984) Polyacrylamide gel electrophoresis of spiral bacteria from the gastric antrum. Lancet 1:1349–1350
Langenberg ML, Tytgat GNJ, Schipper MEI, Rietra PJGM, Zanen HC (1984) Campylobacter-like organisms in the stomach of patients and healthy individuals. Lancet 1:1348
Slomiany BL, Bilski J, Sarosiek J et al. (1987) Campylobacter pyloridis degrades mucin and undermines gastric mucosal integrity. Biochem Biophys Res Commun 144:307–314
Marshall BJ, Hislop I, Glancy R, Armstrong J (1984) Histological improvement of active chronic gastritis in patients treated with De-Nol. Aust N Z J Med 14: (Suppl4) 907
Jones DM, Eldridge J, Whorwell PJ, Miller JP (1985) The effects of various anti-ulcer regimens and antibiotics on the presence of Campylobacter pyloridis and its antibody. In: Pearson AD, Skirrow MB, Lion H (eds) Campylobacter III: Proceedings of the Third International Workshop on Campylobacter Infections. Public Health Laboratory Service, London 161
McNulty CAM, Gearty JC, Crump B et al. (1986) Campylobacter pyloridis and associated gastritis: investigator blind, placebo controlled trial of bismuth salicylate and erythromycin ethylsuccinate. Br Med J 293:645–649
Marshall BJ, Goodwin CS, Warren JR, Blincow ED, Blackborn S et al. (1986) Prospective double-blind study of supplementary antibiotic therapy for duodenal ulcer associated with Campylobacter pyloridis infection. Dig Dis Sci vol 31 (suppl no 10) Abstract 590 (150S)
Langenberg ML, Rauws EAJ, Schipper MEI et al. (1985) The pathogenic role of gastric Campylobacter-like organisms. (GCLO’s) in GCLO-associated gastritis, studied by attempts to eliminate these ]organisms. (Abstract 98). In: Pearson AD, Skirrow MB et al. Campylobacter III: Proceedings of the Third International Workshop on Campylobacter Infections. Public Health Laboratory Service, London, 162–163
Lambert T, Megraud F, Gerbaud G, Courvalin P (1986) Susceptibility of Campylobacter pyloridis to 20 antimicrobial agents. Antimicrob Agents Chemother 30:510– 511
Marshall BJ, McGechie DB, Armstrong JA, Francis G (1985) The antibacterial action of bismuth: early results of antibacterial regimens in the treatment of duodenal ulcer. In: Pearson AD, Skirrow MB et al. (eds) Campylobacter III: Proceedings of the third international workshop on Campylobacter infections. Public Health Laboratory Service, London 165–166
Marshall BJ, Goodwin CS, Warren JR et al. (1986) Prospective double blind study of supplementary antibiotic therapy for duodenal ulcer associated with Campylobacter pyloridis infection. Am J gastroenterol 81:889 (abstr)
Langenberg W, Rauws EAJ, Widjojokusumo A, Tytgat GNJ, Zanen HC (1986) Identification of Campylobacter pyloridis Isolates by Restriction Endonuclease DNA Analysis. J Clin Microbiol 414-417
Morris A, Nicholson G (1986) Campylobacter pyloridis ingestion causing gastritis and hypochlorhydria. Austral Microbiol 7:206
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Rauws, E.A.J., Langenberg, W., Houthoff, H.J., Tytgat, G.N.J. (1988). Attempts to Eradicate Campylobacter pylori — Dutch Experiences. In: Menge, H., Gregor, M., Tytgat, G.N.J., Marshall, B.J. (eds) Campylobacter pylori. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83322-9_43
Download citation
DOI: https://doi.org/10.1007/978-3-642-83322-9_43
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83324-3
Online ISBN: 978-3-642-83322-9
eBook Packages: Springer Book Archive