Skip to main content

Current Theories on Pathogenesis of Peptic Ulcer Disease

  • Conference paper
Campylobacter pylori

Abstract

While in the nineteenth century duodenal ulcer was extremely rare and gastric ulcer was essentially a disease of young women, epidemiology changed during the first half of this century, with male predominance and duodenal ulcers leading by about 4:1 (Langman, 1979). Recently there has been a constant decrease, at least in hospital admissions, for peptic ulcer disease, especially in duodenal ulcers, while the complication rates remain constant or even show a considerable increase in older patients, with hemorrhage and perforation, most probably due to consumption of nonsteroidal anti-inflammatory drugs (Wait et al., 1985).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Allen A, Hutton DA, Leonard AJ, Pearson JP, Sellers LA (1986) The role of mucus in the protection of the gastroduodenal mucosa. Scand J Gastroenterol 21 (suppl 125) 71–77

    Article  CAS  Google Scholar 

  2. Battaglia G, Farini R, DiMario F, Vianello F, Piccoli A, Plebani M, Naccarato R (1985) Is maximal acid output useful in identifying relapsing duodenal ulcer patients? J Clin Gastroenterol 7:375–378

    Article  CAS  PubMed  Google Scholar 

  3. Cohen MM, McCready DR, Clark L (1985) Cigarette smoking reduces human gastric luminal prostaglandin E2. Gut 26:1192–1196

    Article  PubMed  Google Scholar 

  4. Conn HO, Blitzer BL (1976) Non-association of adrenocorticosteroid therapy and peptic ulcer. New Engl J Med 294:473–479

    Article  CAS  PubMed  Google Scholar 

  5. Hunt RH, Howden CW, Jones DB, Burget DW, Kerr GD (1986) The correlation between acid suppression and peptic ulcer healing. Scand J Gastroenterol 21 (suppl 125) 22–29

    Article  Google Scholar 

  6. Isenberg JI, Selling JA, Hogan DL, Koss MA (1987) Impaired proximal duodenal mucosal bicarbonate secretion in patients with duodenal ulcer. New Engl J Med 316:374–379

    Article  CAS  PubMed  Google Scholar 

  7. Ippoliti AF (1985) Prognostic factors in ulcer disease: are they real, are they relevant? J Clin Gastroenterol 7:445–446

    Article  CAS  PubMed  Google Scholar 

  8. Jorde R, Bostad L, Burhol PG (1986) Asymptomatic gastric ulcer: A follow-up study in patients with previous gastric ulcer disease. Lancet 1,119–121

    Article  CAS  PubMed  Google Scholar 

  9. Kumar N, Kumar A, Broor SL, Vij JC, Anand BS (1986) Effect of milk on patients with duodenal ulcers. Br med J 293:666

    Article  CAS  Google Scholar 

  10. Langman MJS (1979) The epidemiology of chronic digestive disease. London, Arnold

    Google Scholar 

  11. McLean AJ, Harrison PM, Joannides-Demos L, Byrne AJ, McCarthy P, Dudley FJ (1985) The choice of ulcer healing agent influences duodenal ulcer relapse rate and long-term clinical outcome. Aust NZ J Med 15:367–374

    Article  CAS  Google Scholar 

  12. Müler-Lissner SA (1986) Bile reflux is increased in cigarette smokers. Gastroenterology 90:1205–1209

    Google Scholar 

  13. Ottenjann R, Bayerdöfer E (1987) Campylobacter pyloridis. Opportunist oder Pathogen im oberen Magen-Darm-Trakt. Dt Äztebl 84:1045–1046

    Google Scholar 

  14. Paffenberger RS, Wing AL, Hyde RT (1974) Chronic disease in former college students. Amer J Epidemiol 100:307–315

    Google Scholar 

  15. Parente F, Lazzaroni M, Sangaletti O, Baroni S, Bianchi-Porro G (1985) Cigarette smoking, gastric acid secretion, and serum pepsinogen I concentrations in duodenal ulcer patients. Gut 26:1327–1332

    Article  CAS  PubMed  Google Scholar 

  16. Röch W, Kinzler E, Demling L (1973)Das Ulcusrezidiv-Langzeitbeobachtungen. In: Demling L, Moser K, Röch W (eds) Das peptische Ulkus. Pathophysiologic, Diagnose, Therapie. Schattauer, Stuttgart-New York

    Google Scholar 

  17. Scheurer U, Witzel L, Halter F, Keller HM, Huber R, Galeazzi R (1977) Gastric and duodenal ulcer healing under placebo treatment. Gastroenterology, 72:838–841

    CAS  PubMed  Google Scholar 

  18. Schwarz K (1910) Uber penetrierende Magen- und Jejunalgeschüre. Bruns Beitr Klin Chir 67:96–128

    Google Scholar 

  19. Soil AH (1986) Mechanisms of action of antisecretory drugs. Scand J Gastroenterol (suppl 125)21:1–6

    Article  Google Scholar 

  20. Sonnenberg A (1986) Smoking and mortality from peptic ulcer in the United Kingdom. Gut 27:1369–1372

    Article  CAS  PubMed  Google Scholar 

  21. Sonnenberg A (1986) Dietary salt is a risk factor in gastric ulcer disease. Gastroenterology 90:1642

    Google Scholar 

  22. Wait R, Katschinski B, Logan R, Ashley J, Langman M (1986) Rising frequency of ulcer perforation in elderly people in the United Kingdom. Lancet 1:489–491

    Google Scholar 

  23. Whitfield PF, Hobsley M (1985) Maximal gastric secretion in smokers and nonsmokers with duodenal ulcer. Brit J Surg 72:955–957

    Article  CAS  PubMed  Google Scholar 

  24. Wormsley KG (1983) Duodenal ulcer: does pathophysiology equal aetiology? Gut 24:775–780

    Article  CAS  PubMed  Google Scholar 

  25. Wormsley KG (1986) Ulcer disease: medical treatment. Current Opinion in Gastroenterology 2:855–868

    Article  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Roesch, W. (1988). Current Theories on Pathogenesis of Peptic Ulcer Disease. In: Menge, H., Gregor, M., Tytgat, G.N.J., Marshall, B.J. (eds) Campylobacter pylori. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83322-9_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-83322-9_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83324-3

  • Online ISBN: 978-3-642-83322-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics