Abstract
Pharmacokinetic considerations are the main rationale for locoregional treatment of hepatic malignancies with anticancer drugs [3, 6,10]. The advantage of regional exposure of arterially infused drugs increases when the blood flow rate into the target region is reduced [6,13]. Impairment of tumor blood flow and synchronous intra-arterial chemotherapy have been employed in various clinical studies using 5-fluorouracil (5-FU) [8, 9, 18]. The antimetabolite 5-FU is activated in the tumor cell, requiring several energy-dependent anabolic steps (Fig. 1). This applies to the drug’s action on RNA as well as DNA synthesis [14, 17]. Whether active carrier-mediated transport into the tumor cell of 5-FU is also involved is still a matter of discussion [17].
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© 1988 Springer-Verlag Berlin Heidelberg
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Eibl-Eibesfeldt, B., Storz, V., Kummermehr, J., Schalhorn, A. (1988). Basic Investigations on Interaction of 5-Fluorouracil and Tumor Ischemia in the Treatment of Liver Malignancies. In: Schlag, P., Hohenberger, P., Metzger, U. (eds) Combined Modality Therapy of Gastrointestinal Tract Cancer. Recent Results in Cancer Research, vol 110. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83293-2_29
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DOI: https://doi.org/10.1007/978-3-642-83293-2_29
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