Effect of Hyperthermia on Human Natural Killer Cells
Natural killer (NK) cells, a subset of lymphocytes, have the ability preferentially to kill virus-infected cells and certain tumor cells in vitro (Herberman et al. 1979). NK cells have been proposed to represent a first level defense mechanism against tumor development and tumor spread in vivo (Herberman 1981; Pollack and Hallenbeck 1982). A correlation between defective NK activity and an increased incidence of malignant disease both in man and in mice supports this concept (Haliotis et al. 1980; Talmadge et al. 1980).
KeywordsDepression Leukemia Hydrocortisone Interferon Prostaglandin
Unable to display preview. Download preview PDF.
- Herberman RB (1981) Significance of natural killer cells in cancer research. Human Lymph Diff 1: 63–76Google Scholar
- Hopwood LE, Zeevi A, Doquesnoy R (1984) Response of human peripheral lymphocytes to hyperthermia (meeting abstr). 32nd Annual meeting of the Radiation Research Society, 25–29 March 1984, Orlando, Florida, p 51Google Scholar
- Shen RN, Shidnia H, Brahmi Z, Hornback NB (1985) Decreased lung metastases and higher natural killer cell activity by whole-body hyperthermia in Lewis lung carcinoma and B16 melanoma (meeting abstr). International Clinical Hyperthermia Society meeting, 21–26 April 1985, Charleston, South CarolinaGoogle Scholar