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Predicting the Sensitivity of Human Cancers to Combined Chemotherapy and Hyperthermia

  • K. Yamada
  • H. A. Neumann
  • H. H. Fiebig
  • R. Engelhardt
  • H. Tokita
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 109)

Abstract

It has been known for quite some time the action of various kinds of antitumor drugs is enhanced when they are administered in combination with hyperthermia, be it in vitro (Hahn 1975; Gross and Parsons 1977; Mizuno et al. 1980), in animals (Marmor 1979; Twentyman et al. 1980, Yamada et al. 1985), or in humans (Stehlin et al. 1975; Arcangeli et al. 1979; Storm et al. 1984). The individual tumors, however, seem to reveal different sensitivities to hyperthermia when the latter is combined with antitumor drugs. With respect to the prediction of tumor response to chemotherapy, clonogenic assay (Salmon et al. 1978; von Hoff et al. 1981; Mann et al. 1982) and subrenal capsule assay (Bogden et al. 1981; Griffin et al. 1983; Levi et al. 1984) have already demonstrated a high probability of clinical response as in vitro and in vivo assays, respectively. These results have added considerably to the possibility that the response to thermochemotherapy for human cancers can also be predicted.

Keywords

Antitumor Agent Renal Carcinoma Antitumor Drug Clonogenic Assay Combine Chemotherapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Andrysek O, Bláhová E, Gregora V, Rezny Z (1985) An experimental model for predicting the synergism of hyperthermia with cytostatics. Neoplasma 32: 93–101PubMedGoogle Scholar
  2. Arcangeli G, Cividalli A, Mauro F, Nervi C, Pavin G (1979) Enhanced effectiveness of adriamycin and bleomycin combined with local hyperthermia in neck node metastases from head and neck cancers. Tumori 65: 481–486PubMedGoogle Scholar
  3. Bogden AE, Cobb WR, Lepage DJ, Haskeil PM, Gulkin TA, Ward A, Kelton DE, Esber HJ (1981) Chemotherapy responsiveness of human tumors as first transplant generation xenografts in the normal mouse: six day subrenal capsule assay. Cancer 48: 10–20PubMedCrossRefGoogle Scholar
  4. Griffin TW, Bogden AE, Reich SD, Antonelli D, Hunter RE, Ward A, Yu DT, Greene HL, Costanza ME (1983) Initial clinical trial of the subrenal capsule assay as a predictor of tumor response to chemotherapy. Cancer 52: 2185–2192PubMedCrossRefGoogle Scholar
  5. Gross P, Parsons PG (1977) The effect of hyperthermia and melphalan on survival of human fibroblast strains and melanoma cell lines. Cancer Res 37: 152–156Google Scholar
  6. Hahn GM (1975) Thermochemotherapy: synergism between hyperthermia (42°–43° C) and adriamycin (or bleomycin) in mammalian cell inactivation. Proc Natl Acad Sci USA 72: 937–940PubMedCrossRefGoogle Scholar
  7. Levi FA, Blum JP, Lemaigre G, Bourut C, Reinberg A, Mathe G (1984) A four-day subrenal capsule assay for testing the effectiveness of anticancer drugs against human tumors. Cancer Res 44: 2660–2667PubMedGoogle Scholar
  8. Mann BD, Kern DH, Giuliano AE, Burk MW, Campbell MA, Morton DL (1982) Clinical correlation with drug sensitivity in the clonogenic assay. Retrospective pilot study. Arch Surg 117: 33–36PubMedCrossRefGoogle Scholar
  9. Mann BD, Storm FK, Morton DL, Bertelsen CA, Korn EL, Kaise LR, Kern DH (1983) Predictability of response to clinical thermochemotherapy by the clonogenic assay. Cancer 52: 1389–1394PubMedCrossRefGoogle Scholar
  10. Marmor JB (1979) Interaction of hyperthermia and chemotherapy in animals. Cancer Res 39: 2269–2276PubMedGoogle Scholar
  11. Mizuno S, Amagi M, Ishida A (1980) Synergistic cell killing by antitumor agents and hyperthermia in culture cells. Gann 71: 471–478PubMedGoogle Scholar
  12. Neumann HA, Fiebig HH, Löhr GW, Engelhardt R (1985) Effect of cytostatic drugs and 40.5° C hyperthermia on human clonogenic tumor cells. Eur J Cancer Clin Oncol 21: 515–523PubMedCrossRefGoogle Scholar
  13. Salmon SE, Hamburger AW, Soehlnen B, Durie BG, Albert D, Moon TE (1978) Quantitation of differential sensitivity of human tumor stem cells to antitumor drugs. N Engl J Med 298: 1321–1327PubMedCrossRefGoogle Scholar
  14. Stehlin JS, Giovanella BC, Ipolyi PD (1975) Results of hyperthermia perfusion for melanoma of the extremities. Surg Gynecol Obstet 149: 17–21Google Scholar
  15. Storm FK, Silberman AW, Ramming KR, Kaise LR, Harrison WH, Elliot RS, Haskel CM, Sarna G, Morton DL (1984) Clinical thermochemotherapy: a control trial in advanced cancer patients. Cancer 53: 863–868PubMedCrossRefGoogle Scholar
  16. Takamizawa H, Sekiya S, Iwasawa H, Ishige H, Tokita H, Tanaka N (1985) A new in vitro chemosensitivity test: individualized chemotherapy against ovarian cancer and its clinical effect. Gan To Kagaku Ryoho 12: 2293–2297PubMedGoogle Scholar
  17. Tokita H, Tanaka N, Ueno T (1982) Morphological changes of tumor cells by antitumor drugs — comparison of in vivo and in vitro. Proceedings of the 41st Japanese Cancer Congress, p 263Google Scholar
  18. Tokita H, Tanaka N, Fugimoto S, Nakao K (1986 a) The in vitro cytotoxic test for predicting human colon and rectum cancer chemosensitivity. Med Biol 112: 171–175Google Scholar
  19. Tokita H, Tanaka N, Ueno T, Fujimoto S, Nakao K, Takada N, Takamizawa H (1986 b) In vitro cytotoxic test for predicting human cancer chemosensitivity. The 14th International Cancer Congress, No 3883 PP 1009 (abstr) Budapest, HungaryGoogle Scholar
  20. Twentyman PR, Morgan JE, Donaldson J (1980) Enhancement by hyperthemia of the effect of BCNU against the EMT 6 mouse tumor. Cancer Treat Rep 64: 439–443Google Scholar
  21. von Hoff DD, Casper J, Bradley E, Sandbach J, Jones D, Makuch R (1981) Association between human tumor colony-forming assays results and response of an individual patient’s tumor to chemotherapy. Am J Med 70: 1027–1032CrossRefGoogle Scholar
  22. Yamada K, Someya T, Shimada S, Nakagawa H, Kukita A, Tokita H, Tanaka N (1985) Thermochemotherapy for malignant melanoma: overcoming heterogeneity in drug sensitivity. J Invest Dermatol 85: 43–64PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • K. Yamada
    • 1
  • H. A. Neumann
    • 1
  • H. H. Fiebig
    • 1
  • R. Engelhardt
    • 1
  • H. Tokita
    • 2
  1. 1.Medizinische KlinikAlbert-Ludwigs-UniversitätFreiburgGermany
  2. 2.Research InstituteChiba Cancer CenterChibaJapan

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