Abstract
The response of tumor cells to hyperthermia is critically influenced by a number of pathophysiological factors both in vitro and in vivo. The most relevant factors in this context are tumor blood flow, tissue oxygenation, the energy status, and the pH distribution, which in turn define the cellular microenvironment.
Supported by the Bundesministerium für Forschung und Technologie (grant 01 VF 034).
We gratefully acknowledge the expert laboratory assistance of Gabriele Berg and the help of Anne Deutschmann-Fleck in preparation of this manuscript and the artwork.
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© 1988 Springer-Verlag Berlin · Heidelberg
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Vaupel, P., Kallinowski, F., Kluge, M. (1988). Pathophysiology of Tumors in Hyperthermia. In: Issels, R.D., Wilmanns, W. (eds) Application of Hyperthermia in the Treatment of Cancer. Recent Results in Cancer Research, vol 107. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83260-4_9
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DOI: https://doi.org/10.1007/978-3-642-83260-4_9
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