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Combined Treatment of Advanced Bladder Carcinoma

  • K.-H. Bichler
  • S. H. Flüchter
  • W. D. Erdmann
  • W. L. Strohmaier
  • J. Steimann
Conference paper
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 107)

Abstract

Extended carcinomas of the bladder mostly run an unfavorable course. As a rule these tumors are resistent to radiation therapy. Intravenous administration of cytostatics promises success as described recently (Cant et al. 1985; Jakse et al. 1985). A concomitant disadvantage, however, is that the drugs in the high concentrations needed for treatment give rise to systemic toxic effects. Attempts to increase tissue concentration of cytostatics by performing a transarterial perfusion of carcinoma gave encouraging results (Aigner 1985). A further rise of cytostatic tissue concentration seems possible if a cytostatic microspheres (Spherex; Pharmacia, Freiburg) carcinoma infusion (CMCI) is performed synchronously. Injected intraarterially, the 45-jim microspheres of starch occlude tumor vessels and cause (a) an accumulation of cytostatics in the center of the tumor, but with low concentrations in the periphery, and (b) transient ischemia in the tumor, the starch molecules being degraded by the body’s amylase (Davis et al. 1984; Fliichter et al. 1986, 1987). An additional activation of cytostatic effectivity must be assumed if adjunctive transurethral high-frequency hyperthermia (TUHH) of the bladder is employed (Fig. 1). This technique when used alone has a damaging effect on transitional cell carcinoma of the bladder (Bichler et al. 1982; Harzmann 1980). This paper describes first experiences of this combined treatment schedule in the field of urology.

Keywords

Radical Cystectomy Transitional Cell Carcinoma Bladder Carcinoma Starch Molecule Urachal Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1988

Authors and Affiliations

  • K.-H. Bichler
    • 1
  • S. H. Flüchter
    • 1
  • W. D. Erdmann
    • 1
  • W. L. Strohmaier
    • 1
  • J. Steimann
    • 1
  1. 1.Abteilung für UrologieUniversität TübingenTübingenGermany

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