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Application of Hyperthermia in the Treatment of Cancer pp 7–16Cite as

Aspects of Metabolic Change After Hyperthermia

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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 107))

Abstract

Heat treatment of cells and tissues leads to instantaneous molecular and metabolic changes. These rapid changes are already observed at temperature ranges (40-45° C) which are used in tumour therapy. Such an immediate metabolic response is not seen after exposure to doses of ionizing radiation within the therapeutic range. Under these conditions metabolic changes are usually observed only several hours or days after exposure (Streffer 1969; Altman et al. 1970). On the other hand, it is very well understood today that DNA damage and effects on the chromosomal level are the most important molecular changes involved in the mechanism of reproductive cell death (Alperl979; Streffer and van Beuningen 1985). The mechanism of heat-induced cell killing is less clear. However, it is evident that molecular processes in the cytoplasm as distinct from the cell nucleus are important for these mechanisms (Hahn 1982; Streffer 1982). Two principal effects can be observed during and after heat treatments (Streffer 1985):

  1. 1.

    Conformational changes, which lead to destabilization of macromolecules and multimolecular structures.

  2. 2.

    Elevated temperatures, which induce increased rates of metabolic reactions. As a consequence a rapid turnover of metabolites occurs which is followed by disregulation.

The investigations were supported by the Bundesministerium für Forschung und Technologie, Bonn.

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References

  • Alper T (1979) Cellular radiobiology. Cambridge University Press, Cambridge

    Google Scholar 

  • Altman D, Gerber GB, Okada S (1970) Radiation biochemistry. Academic, New York

    Google Scholar 

  • Bowler K, Duncan CJ, Gladwell RT, Davison TF (1973) Cellular heat injury. Comp Biochem Physiol [A] 45: 953–963

    Article  Google Scholar 

  • Calderwood SK, Hahn GW (1983) Thermal sensitivity and resistance of insulin-receptor binding. Biochim Biophys Acta 756: 1–8

    Article  PubMed  CAS  Google Scholar 

  • Coss RA, Dewey WC, Bamburg JR (1982) Effects of hyperthermia on dividing Chinese hamster ovary cells and on microtubules in vitro. Cancer Res 42:1059–1071

    PubMed  CAS  Google Scholar 

  • Cress AE, Culver PS, Moon TE, Gerner EW (1982) Correlation between amounts of cellular membrane components and sensitivity to hyperthermia in a variety of mammalian cell lines in cultures. Cancer Res 42: 1716–1721

    PubMed  CAS  Google Scholar 

  • Dickson J, Calderwood SK (1979) Effect of hyperglycemia and hyperthermia on the pH, glycolysis and respiration of the Yoshida sarcoma in vivo. JNCI 63: 1371–1381

    PubMed  CAS  Google Scholar 

  • Francesconi R, Mayer M (1979) Heat- and exercise-induced hyperthermia: effects on high-energy phosphate. Aviat Space Environ Med 50: 799–802

    PubMed  CAS  Google Scholar 

  • Gerweck LE (1977) Modification of cell lethality at elevated temperatures: the pH effect. Radiat Res 70: 224–235

    Article  PubMed  CAS  Google Scholar 

  • Gerweck LE 1985)Environmental and vascular effect. In: Overgaard J (ed) Hyperthermic oncology, vol 2. Taylor and Francis, London, pp 253–262

    Google Scholar 

  • Hahn GM (1982) Hyperthermia and cancer. Plenum, New York Hengstebeck S (1983) Untersuchungen zum Intermediarstoffwechsel in der Leber und in einem Adenocarcinom der Maus nach Hyperthermic. Dissertation, University of Essen

    Google Scholar 

  • Henle KJ, Leeper DB (1979) Effects of hyperthermia (45° C) on macromolecular synthesis in Chinese hamster ovary cells. Cancer Res 39: 2665–2674

    PubMed  CAS  Google Scholar 

  • Jähde E, Rajewsky MF (1982) Sensitization of clonogenic malignant cells to hyperthermia by glucose-mediated, tumour-selective pH reduction. J Cancer Res Clin Oncol 104: 23–30

    Article  PubMed  Google Scholar 

  • Leeper DB (1985) Molecular and cellular mechanisms of hyperthermia alone or combined with other modalities. In: Overgaard J (ed) Hyperthermic oncology 1984. Taylor and Francis, London, pp 9–40

    Google Scholar 

  • Lepock JR, Cheng KH, Al-Qysi H, Kruuv J (1983) Thermotropic lipid and protein transitions in Chinese hamster lung cell membranes: relationship to hyperthermic cell killing. Can J Biochem Cell Biol 61:421–427

    Article  PubMed  CAS  Google Scholar 

  • Lin PS, Turi A, Kwock L, Lu RC (1982) Hyperthermia effect on microtubule organization. Natl Cancer Inst Monogr 61: 57–60

    Google Scholar 

  • Lunec J, Cresswell SR (1983) Heat-induced thermotolerance expressed in the energy metabolism of mammalian cells. Radiat Res 93: 588–597

    Article  PubMed  CAS  Google Scholar 

  • Mirtsch S, Streffer C, van Beuningen D, Rebmann A 1984) ATP metabolism in human melanoma cells after treatment with hyperthermia (42° C). In: Overgaard J. (ed) Hyperthermic oncology 1984. Taylor and Francis, London, pp 19–22

    Google Scholar 

  • Privalov PL (1979) Stability of proteins. Protein Chem 33: 167–241

    Article  CAS  Google Scholar 

  • Reinhold HS, van den Berg-Blok A (1981) Enhancement of thermal damage to the microcirculation of “sandwich” tumours by additional treatment. Eur J Cancer Clin Oncol 17: 781–795

    Article  PubMed  CAS  Google Scholar 

  • Schubert B, Streffer C, Tamulevicius P (1982) Glucose metabolism in mice during and after wholebody hyperthermia. Natl Cancer Inst Monogr 61: 203–205

    CAS  Google Scholar 

  • Stevenson MA, Minto KW, Hahn GM (1981) Survival and concanavalin-A-induced capping in CHO fibroblasts after exposure to hyperthermia, ethanol, and X-irradiation. Radiat Res 86: 467–478

    Article  PubMed  CAS  Google Scholar 

  • Streffer C (1969) Strahlen-Biochemie. Springer, Berlin Heidelberg New York

    Book  Google Scholar 

  • Streffer C (1982) Aspects of biochemical effects by hyperthermia. Natl Cancer Inst Monogr 61: 11–16

    PubMed  CAS  Google Scholar 

  • Streffer C (1985) Metabolic changes during and after hyperthermia. Int J Hyperthermia 1: 305–319

    Article  PubMed  CAS  Google Scholar 

  • Streffer C, van Beuningen D 1985) Zelluläre Strahlenbiologie und Strahlenpathologie (Ganz- und Teilkörperbestrahlung). In: Diethelm L, Heuck F, Olsson O, Strnad F, Vieten H, ZuppingerA. (eds) Handbuch der medizinischen Radiologic, vol 20. Springer, Berlin Heidelberg New York, pp 1–39

    Google Scholar 

  • Streffer C, van Beuningen D (1987) The biological basis for tumour therapy by hyperthermia and radiation. Recent Results Cancer Res 104: 24–70

    Article  PubMed  CAS  Google Scholar 

  • Vaupel P, Kallinowski F (1987) Physiological effects of hyperthermia. Recent Results Cancer Res 104: 71–109

    Article  PubMed  CAS  Google Scholar 

  • Von Ardenne M (1980) Hyperthermia and cancer therapy. Adv Pharmacol Chemother 10:137–138

    Google Scholar 

  • Warburg O, Wind F, Negelein E (1926) Über den Stoffwechsel von Tumoren im Körper. Klin Wochenschr 5: 829–834

    Article  CAS  Google Scholar 

  • Yatvin MB, Cree TC, Elso CE, Gipp JJ, Tegmo I-M, Vorpahl JW (1982) Probing the relationship of membrane “fluidity” to heat killing of cells. Radiat Res 89: 644–646

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Institut für Medizinische Strahlenbiologie, Universitätsklinikum Essen, Hufelandstraße 55, 4300, Essen 1, Germany

    C. Streffer

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  1. C. Streffer
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Editors and Affiliations

  1. Medizinische Klinik III, Klinikum Großhadern, Ludwig-Maximilians-Universität, Marchioninistraße 15, 8000, München 70, Germany

    Rolf D. Issels  & Wolfgang Wilmanns  & 

  2. Gesellschaft für Strahlen- und Umweltforschung (GSF), Institut für Hämatologie, Landwehrstraße 61, 8000, München 2, Germany

    Rolf D. Issels  & Wolfgang Wilmanns  & 

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© 1988 Springer-Verlag Berlin · Heidelberg

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Streffer, C. (1988). Aspects of Metabolic Change After Hyperthermia. In: Issels, R.D., Wilmanns, W. (eds) Application of Hyperthermia in the Treatment of Cancer. Recent Results in Cancer Research, vol 107. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83260-4_2

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  • DOI: https://doi.org/10.1007/978-3-642-83260-4_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83262-8

  • Online ISBN: 978-3-642-83260-4

  • eBook Packages: Springer Book Archive

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