Abstract
Invasion, uncontrolled proliferation, and often metastasis characterize malignant tumors. Benign tumors grow, but do not invade and do not metastasize. Research on the biology of minimal invasion tries to answer three questions: When do tumor cells start to invade? Which genetic alterations lead to acquisition of invasiveness? How do tumor cells invade?
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bolscher JGM, Schallier DCC, Smets LA, van Rooy H, Collard JG, Bruyneel EA, Mareel MMK (1986) Effect of cancer-related and drug-induced alterations in surface carbohydrates on the invasive capacity of mouse and rat cells. Cancer Res 46: 4080–4086
Collard JG, van Beek WP, Janssen JWG, Schijven JF (1985) Transfection by human oncogenes: concomitant induction of tumorigenicity and tumor-associated membrane alterations. Int J Cancer 35: 207–214
Foulds L (1969) Neoplastic development, vol 1. Academic Press, New York
Gabriel O (1982) Carbohydrates and receptor recognition. In: Kahn LD (ed) Hormone receptors. Wiley and Sons, New York, pp 137–156
Greig RG, Koestler TP, Trainer DL, Corwin SP, Miles L, Kline T, Sweet R, Yokoyama S, Poste G (1985) Tumorigenic and metastatic properties of “normal” and ras-transfected NIH/3T3 cells. Proc Natl Acad Sci USA 82: 3698–3701
Heldin C-H, Westermark B (1984) Growth factors: mechanism of action and relation to oncogenes. Cell 37: 9–20
Hynes NE, Jaggi R, Kozma SC, Ball R, Muellener D, Wetherall NT, Davis BW, Groner B (1985) New acceptor cell for transfected genomic DNA: oncogene transfer into a mouse mammary epithelial cell line. Mol Cell Biol 5: 268–272
Land H, Parada LF, Weinberg RA (1983) Cellular oncogenes and multistep carcinogenesis. Science 222: 771–778
Mareel MM (1983) Invasion in vitro: methods of analysis. Cancer Metastasis Rev 2: 201–218
Mareel MM, van Roy FM (1986) Are oncogenes involved in invasion and metastasis? Anticancer Res 6: 419–436
Mareel MM, de Ridder L, de Brabander M, Vakaet L (1975) Characterization of spontaneous, chemical, and viral transformants of a C3H/3T3-type mouse cell line by transplantation into young chick blastoderms. JNCI 54: 923–929
Mareel MM, Kint J, Meyvisch C (1979) Methods of study of the invasion of malignant C3H mouse fibroblasts into embryonic chick heart in vitro. Virchows Arch [Cell Pathol] 30: 95–111
Mareel MM, Bruyneel EA, de Bruyne GK, Dragonetti CH, van Cauwenberge RM-L (1982) Growth and invasion: separate activities of malignant MO4 cell populations in vitro. In: Galeotti T, et al. (eds) Membranes in tumour growth. Elsevier, Amsterdam, pp 223–232
Mareel MM, Bruyneel EA, Dragonetti CH, de Bruyne GK, van Cauwenberge RM-L, Smets LA, van Rooy H (1984) Effect of temperature on invasion of MO4 mouse fibrosarcoma cells in organ culture. Clin Exp Metastasis 2: 107–125
Meneguzzi G, Binétruy B, Grisoni M, Cuzin F (1984) Plasmidial maintenance in rodent fibroblasts of a BPV1-pBR322 shuttle vector without immediately apparent oncogenic transformation of the recipient cells. EMBO J 3: 365–371
Michiels L, van Roy FM, de Saint-Georges L, Mergaert J (1986) Genome organization of the FBRosteosarcoma virus complex: identification of a subgenomic fos-specific message. Virus Res 5: 11–26
Rassoulzadegan M, Naghashfar Z, Cowie A, Can A, Grisoni M, Kamen R, Cuzin F (1983) Expression of the large T protein of polyoma virus promotes the establishment in culture of “normal” rodent fibroblast cell lines. Proc Natl Acad Sci USA 80: 4354–4358
Rautmann G, Glaichenhaus N, Nahgashfar Z, Breathnach R, Rassoulzadegan M (1982) Complementation of a tsa mutant and replication of a recombinant DNA carrying the viral on region in mouse cells transformed by polyoma virus. Virology 122: 306–317
Schallier D, Bolscher J, van Rooy H, Storme G, Smets L (1987) Modification of cell surface carbohydrates and invasive behavior by an alkyllysophospholipid. To be published
Sporn MB, Roberts AB (1985) Autocrine growth factors and cancer. Nature 313: 745–747
Storme GA, Berdel WE, van Blitterswijk WJ, Bruyneel EA, de Bruyne GK, Mareel MM (1985) Antiinvasive effect of racemic 1–0–octadecy1–2–0–methyl glycero–3–phosphocholine (ET–18–OCH3) on MO4 mouse fibrosarcoma cells in vitro. Cancer Res 45: 351 – 357
Thorgeirsson UP, Turpeenniemi-Hujanen T, Williams JE, Westin EH, Heilman CA, Talmadge JE, Liotta LA (1985) NIH/3T3 cells transfected with human tumor DNA containing activated ras oncogenes express the metastatic phenotype in nude mice. Mol Cell Biol 5: 259–262
Van Roy FM, Messiaen L, Liebaut G, Jin G, Dragonetti CH, Fiers WC, Mareel MM (1986) Invasiveness and metastatic capability of rat fibroblast-like cells before and after transfection with immortalizing and transforming genes. Cancer Res 46: 4787–4795
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin · Heidelberg
About this paper
Cite this paper
Mareel, M., van Roy, F., Bruyneel, E., Bolscher, J., Schallier, D., de Mets, M. (1988). Molecular Biology of Minimal Invasion. In: Grundmann, E., Beck, L. (eds) Minimal Neoplasia. Recent Results in Cancer Research, vol 106. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83245-1_3
Download citation
DOI: https://doi.org/10.1007/978-3-642-83245-1_3
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83247-5
Online ISBN: 978-3-642-83245-1
eBook Packages: Springer Book Archive