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Neuroimmunologie Spinale Krankheiten Neuropsychologie Metabolische Enzephalopathien Neurologische Notfälle Interventionelle Neuroradiologie pp 38–48Cite as

Experimental Allergic Encephalomyelitis and Immunosuppression

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Part of the book series: Verhandlungen der Deutschen Gesellschaft für Neurologie ((VDGNEUROLOGIE,volume 4))

Abstract

Testing of potentially therapeutic compounds in experimental animal models is of great importance, particularly when the relevant human condition is not life-threatening, can remit spontaneously and permanently, and has a protracted clinical course. To this end, the model of experimental allergic encephalomyelitis (EAE) has been used, for many years, as a ’testing ground’ for the possible therapeutic value of drugs used in the treatment of patients with multiple sclerosis (MS). EAE is regarded as a potential model for MS for several reasons, including similarities in clinical signs, the appearance of perivascular mononuclear cell infiltrates within the central nervous system (CNS) and, perhaps more importantly, the occurence of CNS-limited demyelination, which appears to result from macrophages stripping myelin whilst sparing the underlying axons (reviewed 44).

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Authors
  1. J. Mertin
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  2. L. A. Mertin
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  1. Abteilung Neurologie der Medizinischen Fakultät, Rheinisch-Westfälische Technische Hochschule Aachen, Pauwelsstraße, D-5100, Aachen, Deutschland

    Klaus Poeck , Werner Hacke  & Rolf Schneider ,  & 

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Mertin, J., Mertin, L.A. (1987). Experimental Allergic Encephalomyelitis and Immunosuppression. In: Poeck, K., Hacke, W., Schneider, R. (eds) Neuroimmunologie Spinale Krankheiten Neuropsychologie Metabolische Enzephalopathien Neurologische Notfälle Interventionelle Neuroradiologie. Verhandlungen der Deutschen Gesellschaft für Neurologie, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83201-7_6

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  • DOI: https://doi.org/10.1007/978-3-642-83201-7_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-18254-2

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