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Central Nervous System Involvement in a Symptomatic Male Syphilitic Human-Immunodeficiency-Virus Carriers

  • E. C. Wolters
  • J. Goudsmit
  • R. V. W. van Eijk
  • H. J. van der Helm
Part of the Verhandlungen der Deutschen Gesellschaft für Neurologie book series (VDGNEUROLOGIE, volume 4)

Summary

Over 20% of homosexual male syphilitic patients had antibodies (ab) to HIV. Of 20 HIV ab positives, 16 also showed intrathecal HIV ab production. Intrathecal HIV ab production was preceeded by seroconversion and accompanied by a rise in IgG index and oligoclonal IgG bands in spinal fluid, indicating specific B-cell clones in the central nervous System. CSF pattern in HIV ab-positive, asymptomatic and PGL/ARC patients displayed quite aspecific abnormalities and paralleled, e.g., the abnormalities found in active neurosyphilis.

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References

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    Goudsmit J, Wolters EC, Bakker M et al. (1986) Intrathecal synthesis of antibodies to HTLV-III in patients without AIDS or AIDS related complex. Br Med J 292:1231–1234CrossRefGoogle Scholar
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    Levy JA, Shimabukuro J, Hollander H et al. (1985) Isolation of AIDS-associated retrovirus from cerebrospinal fluid and brain of patients with neurological Symptoms. Lancet 2:586–588PubMedGoogle Scholar
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    Ho DD, Rota TR, Schooley RT et al. (1985) Isolation of HTLV-III from cerebrospinal fluid and neutral tissues of patients with neurologic Syndromes related to the acquired immunodeficiency Syndrome. N Engl J Med 313:1493–7PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • E. C. Wolters
  • J. Goudsmit
  • R. V. W. van Eijk
  • H. J. van der Helm

There are no affiliations available

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