Central Nervous System Involvement in a Symptomatic Male Syphilitic Human-Immunodeficiency-Virus Carriers
Over 20% of homosexual male syphilitic patients had antibodies (ab) to HIV. Of 20 HIV ab positives, 16 also showed intrathecal HIV ab production. Intrathecal HIV ab production was preceeded by seroconversion and accompanied by a rise in IgG index and oligoclonal IgG bands in spinal fluid, indicating specific B-cell clones in the central nervous System. CSF pattern in HIV ab-positive, asymptomatic and PGL/ARC patients displayed quite aspecific abnormalities and paralleled, e.g., the abnormalities found in active neurosyphilis.
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