Regulation of vascular tone by prostaglandins and endothelium-derived relaxing factor
Prostacyclin is the major prostanoid formed in the vascular wall of conduit arteries. The most important source are endothelial cells which represent only about 5% of the total mass of the vascular wall, but produce about 40% of its prostacyclin (Moncada et al. 1977). Prostacyclin is a potent vasodilator (and an inhibitor of platelet aggregation). Under normal conditions vascular production of prostaglandins is low, however, it can be stimulated by a variety of hormones, autacoids and drugs (Schrör 1985) (cf. below). One major function of the prostacyclin produced could be the mediation or attenuation of the effect of other vasodilator or vasoconstrictor agents, respectively.
KeywordsFatty Acid Derivative Rabbit Aorta Prostacyclin Synthesis Coeliac Artery Diacyl Phospholipid
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