Abstract
Lipoprotein receptors, especially those within the liver, play a central role in the regulation of cholesterol metabolism. Specific apolipoproteins (apo-) serve as the ligands for these receptors (for review, see Mahley and Innerarity, 1983; Mahley et al., 1984; Brown and Goldstein, 1983, 1986).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Blackhart BD, Ludwig EH, Pierroti V, Caiati L, Onasch MM, Wallis SC, Powell L, Pease R, Knott T, Chu ML, Mahley RW, Scott J, McCarthy BJ, and Levy-Wilson B (1986) Structure of the human apolipoprotein B gene. J Biol Chem 261: 15364–15367
Brown MS, Goldstein JL (1983) Lipoprotein receptors in the liver.Control signals for plasma cholesterol traffic. J Clin Invest 72:743–747
Brown MS, Goldstein JL (1986) A receptor-mediated pathway for cholesterol homeostasis. Science 232: 34–47
Hui DY, Innerarity TL, Mahley RW (1981) Lipoprotein binding to canine hepatic membranes. Metabolically distinct apo-E and apoB,E receptors. J Biol Chem 256: 5646–5655
Hui DY, Brecht WJ, Hall EA, Friedman G, Innerarity TL, Mahley RW (1986a) Isolation and characterization of the apolipoprotein E receptor from canine and human liver. J Biol Chem 261: 4256–4267
Hui DY, Hall EA, Brecht WJ, Innerarity TL, Mahley RW (1986b) Molecular cloning and identification of the ligand binding domain of the human apolipoprotein E receptor. Arteriosclerosis 6: 551a
Innerarity TL, Friedlander EJ, Rall SC Jr, Weisgraber KH, Mahley RW (1983) The receptor binding domain of human apolipoprotein E: Binding of apolipoprotein E fragments. J Biol Chem 258: 12341–12347
Innerarity TL, Weisgraber KH, Arnold KS, Rall SC Jr, Mahley RW (1984) Normalization of receptor binding of apolipoprotein E2. Evidence for modulation of the binding site conformation. J Biol Chem 259: 7261–7267
Knott TJ, Rall SC Jr, Innerarity TL, Jacobson SF, Urdea MS, Levy-Wilson B, Powell LM, Pease RJ, Eddy R, Nakai H, Byers M, Priestley LM, Robertson E, Rall LB, Betsholtz C, Shows TB, Mahley RW, Scott J (1985) Human apolipoprotein B: Structure of carboxyl-terminal domains, sites of gene expression, and chromosomal localization. Science 230: 37–43
Knott TJ, Pease RJ, Powell LM, Wallis SC, Rall SC Jr, Innerarity TL, Blackhart B, Taylor WH, Marcel Y, Milne R, Johnson D, Fuller M, Lusis AJ, McCarthy BJ, Mahley RW, Levy-Wilson B, Scott J (1986) Complete protein sequence and identification of structural domains of human apolipoprotein B. Nature 323: 734–738
Mahley RW, Innerarity TL (1983) Lipoprotein receptors and cholesterol homeostasis. Biochim Biophys Acta 737: 197–222
Mahley RW, Hui DY, Innerarity TL, Weisgraber KH (1981) Two independent lipoprotein receptors on hepatic membranes of the dog, swine, and man. Apo-B,E and apo-E receptors. J Clin Invest 68: 1197–1206
Mahley RW, Innerarity TL, Rall SC Jr, Weisgraber KH (1984) Plasma lipoproteins: Apolipoprotein structure and function. J Lipid Res 25: 1277–1294
Mahley RW, Innerarity TL, Rall SC Jr, Weisgraber KH (1985) Lipopro-teins of special significance in atherosclerosis: Insights provided by studies of type III hyperlipoproteinemia. Ann NY Acad Sci 454: 209–221
Mahley RW, Innerarity, TL, Weisgraber KH, Rall SC Jr, Hui DY, Lalazar A, Boyles JK, Taylor JM, Levy-Wilson B (1986) Cellular and molecular biology of lipoprotein metabolism: Characterization of lipoprotein receptor-ligand interactions. Cold Spring Harbor Symp Quant Biol 51. In press
Vogel T, Weisgraber KH, Zeevi MI, Ben-Artzi H, Levanon AZ, Rall SC Jr, Innerarity TL, Hui DY, Taylor JM, Kanner D, Yavin Z, Amit B, Aviv H, Gorecki M, Mahley RW (1985) Human apolipoprotein E expression in Escherichia coli: Structural and functional iden- tity of the bacterially produced protein with plasma apolipoprotein E. Proc Natl Acad Sci USA 82: 8696–8700
Weisgraber KH, Innerarity TL, Harder KJ, Mahley RW, Milne RW, Marcel YL, Sparrow JT (1983) The receptor binding domain of human apolipoprotein E: Monoclonal antibody inhibition of binding. J Biol Chem 258: 12348–12354
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Mahley, R.W. (1987). Lipoprotein Receptors and Their Ligands: Structure and Function of Apoproteins E and B. In: Schettler, G. (eds) Molecular Biology of the Arterial Wall. Veröffentlichungen aus der Geomedizinischen Forschungsstelle der Heidelberger Akademie der Wissenschaften, vol 1987/88 / 1987/4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83118-8_2
Download citation
DOI: https://doi.org/10.1007/978-3-642-83118-8_2
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-17899-6
Online ISBN: 978-3-642-83118-8
eBook Packages: Springer Book Archive