Abstract
The continued uptake of iron by cells is an absolute requirement for maintenance of metabolic functions and for proliferation. The problems confronting the cell are two-fold: a mechanism must exist to allow uptake of iron and this uptake and the distribution of the iron delivered must be regulated. Because it is ferric iron that cells acquire and this ion is insoluble in water a carrier mechanism (transferrin) has evolved. Because the iron is a highly toxic oxidant its delivery to the cell is carefully regulated both at the level of uptake and intracellularly by detoxication mechanisms.
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© 1987 Springer-Verlag Berlin Heidelberg
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Klausner, R.D., Harford, J.B. (1987). The Molecular Basis of Human Cellular Iron Metabolism. In: Schettler, G. (eds) Molecular Biology of the Arterial Wall. Veröffentlichungen aus der Geomedizinischen Forschungsstelle der Heidelberger Akademie der Wissenschaften, vol 1987/88 / 1987/4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83118-8_19
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DOI: https://doi.org/10.1007/978-3-642-83118-8_19
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