Abstract
In spite of the advent of multiple sophisticated intensive care techniques and new antimicrobial drugs, the mortality of septic shock remains very high. Furthermore, the incidence of sepsis and septic shock seems to have increased in the last decades [1].
Preview
Unable to display preview. Download preview PDF.
References
Parillo JE (1984) Septic Shock: Clinical manifestations, pathogenesis, hemodynamics and management in a critical care unit. In: Parillo JE, Ayres SM (eds) Major Issues in Critical Care Medicine. Williams & Wilkins, Baltimore, USA
Kass EH, Ingbar SH, Finland M (1950) Effects of adrenocorticotropic hormone in pneumonia: clinical, bacteriological and serological studies. Ann Intern Med 33: 1081–1098
Schumer W (1976) Steroids in the treatment of clinical septic shock. Ann Surg 184: 333–339
Chernow B, Roth BL (1986) Pharmacologic Support of the Cardiovasculature in Septic Shock. In: Sibbald WJ, Sprung CL (eds) Perspectives on Sepsis and Septic Shock. New Horizons. Society of Critical Care Medicine, Fullterton CA, USA
Mains RE, Fipper BA, Ling N (1977) Common precursor to corticotropins and endorphins. Proc N Atl Acad Sci 74: 3014–3018
Weksler BB, Goldstein IM (1980) Prostaglandins: interaction with platelets and polymorphonuclear leukocytes in hemostasis and inflammation. Am J Med 68: 419–428
Drucker D, Shandling M (1985) Variable adrenocortical function in acute medical illness. Crit Care Med 13: 477–479
Hammerschmidt DE, White JG, Craddock PR (1979) Corticosteroids inhibit complement-induced granulocyte aggregation. A possible mechanism for their efficacy in shock states. J Clin Invest 63: 798–803
Jacob HS, Craddock PR, Hammerschmidt DE, Moldow CF (1980) Complement-induced granulocyte aggregation: an unsuspected mechanism of disease. N Engl J Med 320: 789–794
Skubitz KM, Craddock PR, Hammerschmidt DE, August JT (1981) Corticosteroids block binding of chemotactic peptide to its receptor on granulocytes and cause disaggregation of granulocyte aggregates in vitro. J Clin Invest 68: 13–20
Staub NC (1985) Pathophysiology of acute lung injury. In: Vincent JL (ed) Update in Intensive Care and Emergency Medicine. Springer, Berlin Heidelberg New York Tokyo (Anaesthesiology and Intensive Care Medicine, Vol 178, pp 3–12 )
Nuytinck JKS, Goris RJA, Weerts JGE, Schuurmans Stekhoven JH, Schillings PHM (1987) Whole body inflammation in rabbits, induced by the combination of complement activation and hypoxia. In: Benelux introductory workshop on free radicals in medicine. Veldhoven, The Netherlands
v Bebber IPT, Boekholtz WKF, Goris RJA, Redl H (1987) Lipid peroxydation in an experimental model of Zymosan induced Multiple Organ Failure (MOF) In: Benelux introductory workshop on free radicals in medicine. Veldhoven, The Netherlands
Neuhof H, Platt D, Brähler A, Müller P (1977) Die Wirkung von Prednisolon auf Letalität, Aktivität lysosomaler Enzyme and Hämodynamik bei Endotoxinämie ( Tierexperimentelle Untersuchungen ). Intensivmedizin 14: 378–386
Hinshaw LB, Archer LT, Beller-Todd BK, et al (1981) Survival of primates in lethal septic shock following delayed treatment with steroids. Circ Shock 8: 291–300
Hinshaw LB, Beller-Tod BK, Archer LT, et al (1981) Effectiveness of steroid/antibiotic treatment in primates administered LD 100 Escherichia coli. Ann Surg 194: 51–56
Hinshaw LB, Beller BK, Archer LT, et al (1986) Tobramycin therapy for lethal sepsis in the dog. Crit Care Med 14: 623–628
Hinshaw LB, Beller BK, Chang ACK, et al (1986) Effects of prior administration of steroids upon recovery from lethal sepsis. Surg Gynecol Obstet 163: 335–344
McKechnie K, Furman BL, Parratt JR (1985) Metabolic and cardiovascular effects of endotoxin infusion in conscious unrestrained rats: effects of methylprednisolone and BW755C. Circ Shock 15: 205–215
Klastersky J, Cappel R, Debusscher L (1971) Effectiveness of betamethasone in management of severe infections. A Double-Blind Study. N Engl J Med 284: 1248–1250
Sprung CL, Caralis PV, Marcial EH, et al (1984) The effects of hight-dose corticosteroids in patients with septic shock. A Prospective, Controlled Study. N Engl J Med 311: 11371143
Hoffman SL, Punjabi NH, Kumala S, et al (1984) Reduction of mortality in chloramphenicol-treated severe typhoid fever by high-dose dexamethasone. N Engl J Med 310: 82–88
Weigelt JA, Norcross JF, Borman KR, et al (1985) Early steroid therapy for respiratory failure. Arch Surg 120: 536–540
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Colardyn, F., Vogelaers, D. (1987). Corticosteroids in Patients with Septic Shock. In: Vincent, J.L., Thijs, L.G. (eds) Septic Shock. Update in Intensive Care and Emergency Medicine, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83108-9_21
Download citation
DOI: https://doi.org/10.1007/978-3-642-83108-9_21
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-17861-3
Online ISBN: 978-3-642-83108-9
eBook Packages: Springer Book Archive