Abstract
Innovations in any field are usually based on a substantial foundation of previous efforts of workers in that field. The UCLA Limb-Salvage protocol is no exception. It combines preoperative chemotherapy and radiation with a surgical resection that allows a functioning limb. The combination of preoperative chemotherapy and radiation was chosen to treat subclinical deposits of malignant cells which may not be resected with the grossly evident disease when limb sparing surgery is done. This multi-modality approach has been built upon previous experiences with the combination of radiation and surgery, and the discovery of active chemotherapy agents.
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© 1988 Springer-Verlag Berlin Heidelberg
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Weisenburger, T.H., Barkley, H.T., Zagars, G.K., Lindberg, R.D. (1988). Soft Tissue Sarcoma. In: Withers, H.R., Peters, L.J. (eds) Innovations in Radiation Oncology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83101-0_6
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DOI: https://doi.org/10.1007/978-3-642-83101-0_6
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