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Sensitizers in Radiotherapy

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Innovations in Radiation Oncology

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

The fact that radiotherapy is not 100% successful in controlling local disease means that there is a basis for improving the cure rate of cancer using physical or chemical modifiers of the radiation response of normal or malignant tissues. The goal for the use of sensitizers is to increase the sensitivity of tumor cells to a greater extent than those of the normal tissues which are irradiated along with the tumor. A number of diverse approaches to achieve this goal have emerged from laboratory studies. Some have been tested clinically, while others are still in the development stages. This chapter will review the more promising of these approaches, with the emphasis where possible on their clinical use.

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  1. Stanford University Medical Center, Stanford, CA, 94305, USA

    J. Martin Brown Ph.D. (Professor)

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  1. J. Martin Brown Ph.D.
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Editors and Affiliations

  1. Division of Experimental Radiation Oncology, Department of Radiation Oncology, University of California, 90024, Los Angeles, CA, USA

    H. Rodney Withers M.D., D.Sc. (Director, Professor) (Director, Professor)

  2. Division of Radiotherapy, The University of Texas M.D. Anderson Hospital and Tumor Institute, 77030, Houston, TX, USA

    Lester J. Peters M.D. (Professor and Head) (Professor and Head)

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© 1988 Springer-Verlag Berlin Heidelberg

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Brown, J.M. (1988). Sensitizers in Radiotherapy. In: Withers, H.R., Peters, L.J. (eds) Innovations in Radiation Oncology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83101-0_23

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  • DOI: https://doi.org/10.1007/978-3-642-83101-0_23

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