Abstract
Antithrombin III is formed in the liver. It inhibits first of all factor II a (thrombin) and factor Xa. In addition factors VIIa, IXa, XIa, XIIa, plasmin and kallikrein are inhibited. The plasma concentration is between 14 mg and 20 mg/100 ml of plasma, or between 80 and 120% of the norm. The biological half-life is 2.8 ° 0.3 days. A drop in antithrombin III to 70–80% of the norm is accompanied by an increased tendency to thrombosis. Antithrombin III deficiency may be congenital or acquired (Table 1).
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© 1987 Springer-Verlag Berlin Heidelberg
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Matthias, F.R. (1987). Coagulation Factor Deficiencies with Tendency to Thrombosis. In: Blood Coagulation Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83098-3_12
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DOI: https://doi.org/10.1007/978-3-642-83098-3_12
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-17813-2
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