Abstract
Presently adult respiratory distress syndrome (ARDS) and the subsequent syndrome with Multiple Organ Failure (MOF) and sepsis are the main causes of death in an up-to-date surgical and intensive care department. Despite intensive treatment, and support of the failing organ functions, mortality of the MOF syndrome still is around 60%. MOF is generally believed to be the result of bacterial sepsis, though it has been recently shown that — at least in trauma patients — no dependable correlation is present between positive bacterial blood cultures and “sepsis” [1].
Preview
Unable to display preview. Download preview PDF.
References
Goris RJA, te Boekhorst TPA, Nuytinck JKS, Gimbrère JSF (1985) Multiple-Organ Failure. Generalized autodestructive inflammation? Arch Surg 120:1109–1115
Goris RJA, Boekholtz WKF, van Bebber IPT, Nuytinck JKS, Schillings PHM (1986) Multiple-organ failure and sepsis without bacteria. An experimental model. Arch Surg 121:897–901
Goris RJA, Nuytinck JKS, Boekholtz WKF, van Bebber IPT, Schillings PHM (1986) Multiple organ failure and sepsis without bacteria: An experimental model. In: Novelli, Ursini (eds) Oxygen Free Radicals in Shock. Karger, Basel, pp 109–113
Nuytinck JKS, Goris RJA, Redl H, Schlag G, van Munster PJJ (1986) Posttraumatic complications and inflammatory mediators. Arch Surg 121:886–890
Border J, LaDuca J, Seibel R (1975) Priorities in the management of the patient with polytrauma. In: Allgower M, Bergentz S, Calne R, Gruber US (eds) Progress in Surgery, Karger, Basel, pp 87–122
Seibel R, LaDuca J, Hassett JM, et al (1985) Blunt multiple trauma (ISS 36), femur traction, and the pulmonary failure-septic state. Ann Surg 202:283–295
Goris RJA, Draaisma J (1982) Causes of death after blunt trauma. J Trauma 22:141–146
Jacobs RR, McClain OM (1981) Effects of fracture stabilization by internal fixation. Injury 12:194–201
Jansson I, Eriksson R, Liljedahl S-O, Loven L, Rammer L, Lennquist S (1982) Primary fracture immobilization as a method to prevent post-traumatic pulmonary changes — an experimental model. Acta Chir Scand 148:329–338
Goris RJA (1983) The Injury Severity Score. World J Surg 7:12–18
Johnson KD, Cadambi A, Seibert GB (1985) Incidence of adult respiratory distress syndrome in patients with multiple musculoskeletal injuries: effect of early operative stabilization of fractures. J Trauma 25:375–384
Meek RN, Vivoda EE, Pirani S (1986) Comparison of mortality of patients with multiple injuries according to type of fracture treatment — a retrospective age- and injury-matched series. Injury 17:2–4
Rüedi Th, Wolff G (1975) Vermeidung posttraumatischer Komplikationen durch frühe definitive Versorgung von Polytraumatisierten mit Frakturen des Bewegungsapparats. Helv Chir Acta 42:507–512
Goris RJA, Gimbrère JSF, van Niekerk JLM, Schoots FJ, Booy LHD (1982) Early osteosynthesis and prophylactic mechanical ventilation in the multitrauma patient. J Trauma 22:895–903
Wallraf R, Wissing H (1982) Infektraten nach primarer und sekundarer Osteosynthese geschlossener Frakturen bei polytraumatisierten. Hefte zur Unfallheilkunde 157:91–92
Wolff G, Diettman M, Rüedi Th. Buchmann B, Allgöwer M (1978) Koordination von Chirurgie und Intensivmedizin zur Vermeidung der posttraumatischen respiratorischen Insuffizienz. Unfallheilkunde 81:425–442
Sturm JA, Lewis FR, Trentz O, Oestern H-J, Hempelman G, Tscherne H (1979) Cardiopulmonary parameters and prognosis after severe multiple trauma. J Trauma 19:305–318
Schmidt GB, O’Neill WW, Kotb K (1976) Continuous positive airway pressure in the prophylaxis of the adult respiratory distress syndrome. Surg Gynecol Obstet 143:613–618
Valdes ME, Powers SR, Shah DM, Newell JC, Scovill WA, Dutton RE (1978) Continuous positive airway pressure in prophylaxis of adult respiratory distress syndrome in trauma patients. Surg Forum 29:187–189
Weigelt JA, Mitchell A, Snyder WH (1979) Early positive end-expiratory pressure in the adult respiratory distress syndrome. Arch Surg 114:497–501
Pepe PE, Hudson LD, Carrico CJ (1984) Early application of positive end-expiratory pressure in patients at risk for the adult respiratory distress syndrome. N Engl J Med 311:281–286
Sheikh MA (1981) Respiratory changes after fractures and surgical skeletal injury. Injury 13:489–494
Borg T, Modig J (1985) Positive effects of prophylactic ventilator treatment on gas exchange and extravascular lung water in a porcine model of adult respiratory distress syndrome induced by endotoxaemia. Acta Chir Scand 151:501–508
Nuytinck JKS, Goris RJA, Weerts JGE, Schillings PHM, Schuurmans, Stekhoven JH (1986) Acute generalized microvascular injury by activated complement and hypoxia; the basis of the adult respiratory distress syndrome and multiple organ failure? Br J Exp Pathol 67:537–548
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Goris, R.J.A. (1987). Can ARDS and MOF Be Prevented?. In: Vincent, J.L. (eds) Update 1987. Update in Intensive Care and Emergency Medicine, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83042-6_18
Download citation
DOI: https://doi.org/10.1007/978-3-642-83042-6_18
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-17576-6
Online ISBN: 978-3-642-83042-6
eBook Packages: Springer Book Archive