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Chromogenic Peptide Substrate Assays

A Growing Concept in Intensive Care Medicine

  • Chapter
Update 1987

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 3))

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Abstract

Activation of proteases is frequently seen in patients treated in the intensive care unit. This is well known for proteases of the coagulation and fibrinolytic systems [1, 2].

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References

  1. Hirsch EF, Fletcher IR, Moquin R (1971) Coagulation changes after combat trauma and sepsis. Surg Gynecol Obstet 133:393–398

    PubMed  CAS  Google Scholar 

  2. Hawiger J (1976) Disseminated intravascular coagulation in patients with infection: Diagnostic and therapeutic approaches. Mater Med Pol 8:206–211

    PubMed  CAS  Google Scholar 

  3. Fearon DT, Ruddy S, Schur PH (1975) Activation of the properdin pathway of complement in patients with gram-negative bacteremia. N Engl J Med 293:937–940

    Article  Google Scholar 

  4. O’Donnell TF, Clowes GHA (1976) Kinin activation in the blood of patients with sepsis. Surg Gynecol Obstet 143:539–544

    PubMed  Google Scholar 

  5. Aasen AO, Smith-Erichsen N, Gallimore MJ, Amundsen E (1980) Studies on the components of the plasma kallikrein-kinin system in plasma samples from normal individuals and patients with septic shock. In: Advances in Shock Research Vol IV. Alan R. Liss Inc. New York, pp 1–10.

    Google Scholar 

  6. Fritz H (1980) Proteinase inhibitors in severe inflammatory processes (septic shock and experimental endotoxemia): Biochemical, pathophysiological and therapeutic aspects. In: Protein Degradation in Health and Disease. Ciba Foundation Symp 75 (new series) 351. Excerpta Medica, Amsterdam, pp 351–379

    Google Scholar 

  7. Smith-Erichsen N, Aasen AO, Amundsen E (1982) Treatment of sepsis in the surgical patient evaluated by means of chromogenic peptide substrate assays. Acta Chir Scand 509:33–38

    CAS  Google Scholar 

  8. Kalter ES, Timmermans A, Bouma BN (1982) The kinin generating system during sepsis and bacterial shock, Agents and Actions 9:638–644

    Google Scholar 

  9. Aasen AO, Kierulf P, Ruud TE (1982) Studies on pathological plasma proteolysis in patients with acute pancreatitis. A preliminary report. Acta Chir Scand 509:83–89

    CAS  Google Scholar 

  10. Aasen AO, Kierulf P, Vaage J (1983) Determination of components of the plasma proteolytic enzyme systems gives information of prognostic value in patients with multiple trauma. Adv Exp Med Biol 15615:1037–1047

    Google Scholar 

  11. Lasson A (1984) Acute pancreatitis in man. A clinical and biochemical study of pathophysiology and treatment. Scand J Gastroenterol, suppl 99

    Google Scholar 

  12. Kaplan AP, Meier HL, Mandle R (1976) The Hageman factor dependent pathways of coagulation, fibrinolysis and kinin generation. Semin Thromb Hemost 3:1–26

    PubMed  CAS  Google Scholar 

  13. Laurell CB, Jeppson JO (1975) Protease inhibitors in plasma. In: Putnam J (ed) The plasma proteins. Academic Press. New York pp 229–264

    Google Scholar 

  14. Svendsen L, Blombäck B, Blombäck M, Olsson P (1972) Synthetic chromogenic substrates for determination of trypsin, thrombin and thrombin-like enzymes. Thromb Res 1:267–273

    Article  CAS  Google Scholar 

  15. Amundsen E, Gallimore MJ, Aasen AO, Larsbraaten M, Lyngaas K (1978) Activation of human plasma prekallikrein: influence of activators, activation and temperature and inhibitors. Thromb Res 13:625–632

    Article  PubMed  CAS  Google Scholar 

  16. Friberger P (1982) Chromogenic peptide substrates. Their use for the assay of factors in the fibrinolytic and the plasma kallikrein-kinin systems. Scand J Clin Lab Invest Suppl 162

    Google Scholar 

  17. Aasen AO, Kierulf P, Strömme JH (1982) Methodological considerations on chromogenic peptide substrate assays and application on automated analyzers. Acta Chir Scand 509:17–23

    CAS  Google Scholar 

  18. Aasen AO, Ruud TE, Kaaresen R, Stadaas JO (1986) Evaluation of patients with acute pancreatitis by means of chromogenic peptide substrate assays and the proenzyme functional inhibition index (PFI index). Scand J Gastroenterol 126:40–45

    Article  CAS  Google Scholar 

  19. Aasen AO (1985) The proenzyme functional inhibition index. A new parameter for evaluation of the severely injured and septic patient. Acta Chir Scand 522:211–233

    CAS  Google Scholar 

  20. Smith-Erichsen N, Aasen AO (1984) Evaluation of severity and prognosis in early stages of septicemia by means of chromogenic peptide substrate assays. Eur Surg Res 2:140–146

    Article  Google Scholar 

  21. Blauhut B, Kramar H, Vinazzer H, Bergmann H (1985) Substitution of antithrombin II in shock and DIC: A randomized Study. Thrombos Res 39:81–89

    Article  CAS  Google Scholar 

  22. Starre P van der, Sinclair D, Damen J, Brammelhuis H (1980) Inhibition of the hypotensive effect of plasma protein solutions by CI-esterase inhibitor. J Thorac Cardiovasc Surg 79:738–740

    PubMed  Google Scholar 

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Authors
  1. A. O. Aasen
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Editor information

Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean Louis Vincent (Assistant-Director) (Assistant-Director)

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© 1987 Springer-Verlag Berlin Heidelberg

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Aasen, A.O. (1987). Chromogenic Peptide Substrate Assays. In: Vincent, J.L. (eds) Update 1987. Update in Intensive Care and Emergency Medicine, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83042-6_16

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  • DOI: https://doi.org/10.1007/978-3-642-83042-6_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17576-6

  • Online ISBN: 978-3-642-83042-6

  • eBook Packages: Springer Book Archive

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