Abstract
Heat has been used through the ages as a therapeutic agent. Hippocrates (470–377 B. C.) stated that a patient who could not be cured by heat was actually incurable. He adapted the bathing customs of the Egyptians to ancient Greece and induced hyperthermia in patients suffering from paralysis. The Japanese of the seventeenth century performed hyperthermia by balneotherapy. They treated syphilis, arthritis, and gout by using hot water at temperatures between 45° and 53° C. Thus the body temperature was elevated to at least 39° C (Giles 1938).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abe M, Hirooka M (1985) Review, localized hyperthermia and radiation in cancer therapy. Int J Radiat Biol 47: 347–359
Abe M, Hirooka M, Takahashi M (1982) Combination of hyperthermia and radiation in cancer therapy. Strahlentherapy 158: 275–280
Arcangeli G, Nervi C (1984) The lack of clinical evidence of tumor thermotolerance after some schedules of combined heat and radiation. In: Overgaard I(es) Proceedings of the 4th international symposium on hyperthermic oncology, vol. 1, Summary papers. Taylor and Francis, London, pp 231–234
Arcangeli G, Civadilli A, Nervi C, Creton G (1983) Tumor control and therapeutic gain with different schedules of combined radiotherapy and local external hyperthermia in human cancer. Int J Radiat Oncol Biol Phys 9: 1125–1134
Arcangeli G, Nervi C, Cividalli A, Lovisolo GA (1984) Problem of sequence and fractionation in the clinical application of combined heat and radiation. Cancer Res (Suppl) 44: 4857–4863
Arcangeli G, Guersa A, Lovisolo G, Civadelli A, Marino C, Mauro F (1985) Tumour response to heat and radiation: prognostic variables in the treatment of nech node metastases from head and neck cancer. Int J Hyperthermia 1: 207–217
Arons J, Sokoloff B (1937) Combined roentgenotherapy and ultrashort wave. Am J Surg 36: 533–543
Baker HW, Snedecor PA, Goss IC (1982) Regional hyperthermia for cancer. Am J Surg 143: 586–590
Ben-Hur E, Elkind MM, Bronk BV (1974) Thermally enhanced radioresponse of cultured Chinese hamster cells: inhibition of repair of sublethal damage and enhancement of lethal damage. Rad Res 58: 38–51
Bicher HI, Mitagvaria PN (1984) Changes in tumor tissue oxygenation during microwave hyperthermia clinical relevance. In: Overgaard I (ed) Hyperthermic oncology 1984, vol 1. Summary papers. Taylor and Francis, London, pp 169–173
Bicher HI, Sandhu TS, Hetzel FW (1980) Hyperthermia and radiation in combination: a clinical fractionation regime. Int J Radiat Oncol Biol Phys 6: 867–870
Bicher HI, Wolfstein RS (1984) Microwave hyperthermia as an adjuvant to radiation therapy. Summary experience of 208 multifraction treatment cases. In: Overgaard I (ed) Proceedings of the fourth international symposium on hyperthermic oncology, vol 1, summary papers. Taylor and Francis, London pp 363–366
Bleehen NM (1985) Hyperthermia in the next stage in the oncologist’s odyssey. In: Overgaard I (ed) Proceedings of the 4th international symposium on Hyperthermic oncology, vol 2. Review lectures, symposium summaries and workshop summaries. Taylor and Francis, London, pp 371–383
Bruggmoser G, Hinkelbein W, Engelhardt R, Wannenmacher M (eds) (1986) Locoregional high-frequency hyperthermia and temperature measurement Springer, Berlin Heidelberg New York Tokyo (Recent results in cancer research, vol 101)Bruns P (1888) Die Heilwirkung des Erysipels auf Geschwülste. Beitr Klin Chir 3, 443
Busch W (1866) Über den Einfluß, welchen heftigere Erysipele zuweilen auf organisierte Neubildungen ausüben. Verhandl. des naturhistorischen Vereines der preußischen Rheinlande und Westphalens. 23, 28–30
Coley WB (1893) The treatment of malignant tumors by repeated inoculations of erysipelas, with a report of ten original cases. Am J Med Sci 105: 487–511
Coley WB (1894) Treatment of inoperable malignant tumors with the toxins of erysipelas and the Bacillus prodigiosus. Am J Med Sci 108: 50–66
Coley WB (1911) A report of recent cases of inoperable sarcoma successfully treated with mixed toxins of erysipelas and Bacillus prodigiosus. Surg Gynecol Obstet 13: 174–190
Dewey WC, Freeman MC, Raaphorst GP, Clark EP, Wong RSL, Highfield DP, Spiro IJ, Tomasovic SP, Denman DL, Coss RA (1980) Cell biology of hyperthermia and radiation. In: Meyn RE, Withers HR (eds) Radiation biology in cancer research. Raven, New York, pp 589–621
Cony PM, Barlogie P, Tilchen EJ, Armour EP (1982b) Ultrasound-induced hyperthermia for the treatment of human superficial tumors. Int J Radiat Oncol Biol Phys 8: 1225–1229
Cosset JM, Dutreix J, Dufour J, Janora P, Damia E, Haie C, Clarke D (1894) Combined interstitial hyperthermia and brachytherapie institute Gustave Roussy technique and preliminary results. Int J Radiat Oncol Biol Phys 10: 307–312
Coughlin CT, Wong TZ, Strohbehn JW, Collacchio TA, Sutton JE, Belch RZ, Douple EB (1985) Intraoperative interstitial microwave-induced hyperthermia and brachytherapy. Int J Radiat Oncol Biol Phys 11: 1673–1678
Dewey WC (1985) Summary of biological studies. In: Overgaard I (ed) Proceedings of the 4th international symposium on hyperthermic oncology, vol 2: review lectures, Symposium sumaries and Workshop summaries. Taylor and Francis, London, pp 341–351
Dewey WC, Freeman MC, Raaphorst GP, Clark EP, Wong RSL, Highfield DP, Spiro IJ, Tomasovic SP, Denman DL, Coss RA (1980) Cell biology of hyperthermia and radiation. In: Meyn RE, Withers HR (eds) Radiation biology in cancer research. Raven, New York, pp 589–621
Dewhirst MW, Connor WG, Sim DA (1982) Preliminary results of a phase III trial of spontaneous animal tumors to heat and/or radiation: early normal tissue response and tumor volume influence on initial response. Int J Radiat Oncol Biol Phys 8: 1951–1961
Dewhirst MW, Sim DA, Sapareto S (1984) Importance of minimum tumor temperature in determining early and long-term responses of spontaneous canine and feline tumors to heat and radiation. Cancer Res 44: 43–50
Dietzel F ( 1975 a) Tumor und Temperatur. Aktuelle Probleme bei der Anwendung thermischer Verfahren in Onkologie und Strahlentherapie. Urban and Schwarzenberg, Munich
Dietzel F ( 1975 b) A summary and overview of cancer therapy with hyperthermia in Germany. Proceedings of the international symposium on cancer therapy by hyperthermia and radiation. Washington, D.C., April 28–30.
The American College of Radiology, pp 75–84
The Combination of Hyperthermia and Radiation: Clinical Investigations 131
Dietzel F, Ringleb D, Schneider U, Wricke H (1975) Microwave in radiotherapy of tumors–alternative to heavy particles Strahlentherapie 146: 438–441
Elliott RS, Harrison WH, Storm FK (1982) Hyperthermia: electromagnetic heating of deep-seated tumors. IEEE Trans Biomed Eng 29: 61–64
Fajardo L-G (1984) Pathological effects of hyperthermia in normal tissues. Cancer Res. (Suppl) 44: 4826–4835
Fazekas JT, Nerlinger RE (1981) Localized hyperthermia to irradiation in superficial recurrent carcinomas: a preliminary report on 46 patients. Int J Radiat Oncol Biol Phys 7: 1457–1461
Fessenden P (1984) Ultrasound methods for inducing hyperthermia. Frontiers Radiat Ther Oncol18: 62–69
Field SB (1978) The response of normal tissues to hyperthermia alone or in combination with x-rays. In: Streffer C et al. (ed) Cancer therapy by hyperthermia and radiation. Urban and Schwarzenberg, pp 37–48
Field SB, Bleehen NM (1979) Hyperthermia in the treatment of cancer. Cancer Treat Rep 6: 63–94
Field SB (1983) Cellular and tissue effect of hyperthermia and radiation. In: Steel GG et al. (eds) The biological basis of radiotherapy. Elsevier, Amsterdam, pp 287–303
Field SB (1985) Clinical implications of thermotolerance. In: Overgaard I (ed) Proceedings of the 4th international symposium on hyperthermic oncology, vol 2. Review lectures, symposium summaries and workshop summaries. Taylor and Francis, London, PP 235–244
Gerner EW (1985) Definition of thermal dose. Biological isoeffect relationships and dose for temperature-induced cytotoxicity. In: Overgaard I (ed) Proceedings of the 4th international symposium on hyperthermic oncology, vol 2. Review lectures, symposium summaries and workshop summaries. Taylor and Francis, London, pp 245–251
Gerhard H, Scherer E (1983) Lokalhyperthermie in der Behandlung fortgeschrittener Tumoren: kurative und palliative Wirkungen. Strahlentherapie 159: 521–531
Gibbs FA (1983) “Thermal mapping” in experimental cancer treatment with hyperthermia: description and use of a semiautomatic system. Int J Radiat Oncol Biol Phys 9: 1057–1063
Gibbs FA (1984 a) Noninvasive electromagnetic heating techniques and the operational characteristics of the annular phased array (APA). Front Radiat Ther Oncol 18: 56–61
Gibbs FA (1984b) Regional hyperthermia: a clinical appraisal of noninvasive deep-heating methods. Cancer Res (Suppl) 44: 4765–4770
Gibbs FA, Sapozink MD, Gates KS, Stewart JR (1984) Regional hyperthermia with an annular phased array in the experimental treatment of cancer. Report of work in progress with a technical emphasis. IEEE Trans Biomed Eng 31: 115–119 (1984)
Gibbs FA, Sapozink MD, Steward JR (1985) Clinical thermal dosimetry: why and how. In: Overgaard J (ed) Proceedings of the 4th international symposium on hyperthermic oncology, vol 2. Review lectures, symposium summaries and workshop summaries. Taylor and Francis, London, pp 155–167
Giles U (1938) The historic development and modern applications of artificial fewer. New Orleans Med Soc J 91: 655–670
Hagmann MS, Levin RL (1983) Numerical evaluation of the helical-coil applicator for hyperthermia Abstr Radiat Res 94: 534
Hahn GM (1982) Hyperthermia and cancer. Plenum, New York
Hall EJ (1978) Radiobiology for the radiologist. Harper and Row, Hagerstown
Henle KJ, Dethlefsen LA (1978) heat fractionation and thermotolerance: a review. Cancer Res 38: 18431851
Henle KJ, Dethlefsen LA (1978) heat fractionation and thermotolerance: a review. Cancer Res 38: 1843–1851
Herbst M, Sauer R (1983) Zur Tumorbehandlung mit Hyperthermie und Radiotherapie. Strahlentherapie159: 93–98
Hofman P, Langendijk JJW, Schipper J (1984) The combination of radiotherapy with hyperthermia in protocolzed clinical studies. in: Overgaard I (ed) Proceedings of the fourth international symposium on hyperthermic oncology, vol I, summary papers. Taylor and Francis, London, p 379–382
Hymmen U, Wieland C (1976) Leistung and Wirkungsmechanismus einer lokalen kombinierten Strahlentherapie–Wärmeanwendung. Med Klin 71: 1183–1187
Issels RD, Biaglow JE, Epstein L, Gerweck LE (1984) Enhancement of cystamine cytotoxicity by hyperthermia and its modification by catalase and superoxide dismutase in Chinese hamster ovary cells. Cancer Res 44: 3911–3915
Jähde E, Rajewski MF (1982) Sensitization of clonogenic malignant cells to hyperthermia by glucose-mediated, tumor-selective pH reduction. J Cancer Res Clin Oncol 104: 23–30
Johnson HJ (1940) The action of short radiowaves on tissues: III A comparison of the thermal sensitivities of transplantable tumors in vivo and in vitro. Am J Cancer 38: 533–550
Jung H (1983) Modification of thermal response by fractionation of hyperthermia. Strahlentherapie 159: 67–72
Kim SH, Kim JH, Hahn EW (1978) Selective potentiation of hyperthermia killing of hypoxic cells by 5-thio D-glucose. Cancer Res 38: 2935–2938
Kim JH, Hahn EW, Ahmed SA (1982 a) Combination hyperthermia and radiation therapy for malignant melanoma. Cancer 50: 478–482
Kim JH, Hahn EW, Antich PP (1982b) Radiofrequency hyperthermia for clinical cancer therapy. Nat Cancer Inst Monogr 61: 339–342
Lambert RA (1912) Demonstration of the greater susceptibility to heat of sarcoma cells as compared with actively proliferating connective-tissue cells. JAMA 59: 2147
Lele PP (1985) Ultrasound: is it the modality of choice for controlled localized heating of deep tumors? In: Overgaard J (ed) Hyperthermic oncology, vol 2. Review lectures, symposium summaries and workshop summaries. Proceedings of the 4th international symposium on hyperthermic oncology. Taylor and Francis, London, pp 129–154
Li GC, Evans RG, Hahn GM (1976) Modification and inhibition of repair of potentially lethal x-ray damage by hyperthermia. Radiat Res 67: 491–501
Li RY, Zhang TZ, Lin SY, Wang HP (1984) Effect of hyperthermia combined with radiation in the treatment of superficial malignant lesion in 90 patients. In: Overgaard J (ed) Proceedings of the 4th international symposium on hyperthermic oncology, vol 1, summary papers. Taylor and Francis, London, 395–397
Liebesny P (1921) Experimentelle Untersuchungen liber Diathermie. Wien Klin Wschr 34: 117–118
Lindholm CE, Kjellen E, Landberg T, Nilsson P, Hertzman S, Persson B (1984) Microwave-induced. hyperthermia and radiotherapy. Clinical results. In: Overgaard J (ed) Proceedings of the 4th international symposium on hyperthermic oncology, vol 1, summary papers. Taylor and Francis, London, pp 341–344
Luk KH, Purser PR, Castro JR, Meyler TS, Philips TL (1981) Clinical experiences with local microwave hyperthermia. Int J Radiat Oncol Biol Phys 7: 615–619
Luk KH, Pajak TF, Perez CA, Johnson RA, Conner N, Dobbins T (1984a) Prognostic factors for tumor response after hyperthermia and radiation. In: Overgaard J (ed) Proceedings of the 4th international symposium on hyperthermic oncology, vol 1, summary papers. Taylor and Francis, London, pp 353–356
Luk KH, Francis ME, Perez CA, Johnson RJ (1984b) Combined radiation and hyperthermia: comparison of two treatment schedules based on data from a registry established by the radiation therapy oncology group (RT06). Int J Radiat Oncol Biol Phys 10: 801–809
Manning MR, Cetas TC, Miller RC, Oleson JR, Connor WG, Gerner EW (1982) Clinical hyperthermia: results of a phase I trial employing hyperthermia alone or in combination with external beam or interstitial radiotherapy. Cancer 49: 205–216
Marmor JB (1983) Cancer therapy by ultrasound. In: Advances in radiation biology, vol 10. Academic, New York, pp 105–133
Marmor JB, Hahn GM (1980) Combined radiation and hyperthermia in superficial human tumors. Cancer 46: 1986–1991
Marmor JB, Pounds D, Hahn GM (1982) Clinical studies with ultrasound-induced hyperthermia. Nat Cancer Inst Monogr 61: 333–337
Mendecki J, Friedenthal E, Botstein C (1980) Microwave applicators for localized hyperthermia treatment of cancer of the prostate. Int J Radiat Oncol Biol Phys 6: 1583–1588
Meoz RT, Corry P, Frazier OH, Barlogie B, Armour E (1983) Hyperthermia and radiation therapy for the treatment of intrathoracic human malignant tumors: initial clinical and technical observations (abstract). Radiat Res 94: 541
The Combination of Hyperthermia and Radiation: Clinical Investigations 133
Müller C (1910) Eine neue Behandlungsmethode bösartiger Geschwülste. Minch Med Wschr 57: 1490–1493
Müller C (1920) Ober Stand und Ziele der Röntgentiefentherapie der Karzinome. Strahlentherapie 10: 749–757
Nauts HC (1985) Hyperthermic oncology: historic aspects and future trends. In: Overgaard J (ed) Hyperthermic oncology, vol 2. Review lectures, symposium summaries and workshop summaries. Proceedings of the 4th international symposium on hyperthermic oncology. Taylor and Francis, London, pp 199–209
Oleson JR (1984) A review of magnetic induction methods for hyperthermia treatment of cancer. IEEE Trans Biomed Eng 31: 91–97
Oleson JR, Cetas TC, Cony PM (1983 a) Hyperthermia by magnetic induction: experimental and theoretical results for coaxial coil pairs. Radiat Res 95:175–186
Oleson JR, Heusinkveld RS, Manning MR ( 1983 b) Hyperthermia by magnetic induction: II. Clinical experience with concentric electrodes. Int J Radiat Oncol Biol Phys 9: 549–556
Oleson JR, Sim DA, Manning MR (1984) Analysis of prognostic variables in hyperthermia treatment of 161 patients. Int J Radiat Oncol Biol Phys 10: 2231–2239
Overgaard K (1934) Über Wärmetherapie bösartiger Tumoren. Acta Radiol 15: 89–100
Overgaard K, Okkels H (1940) The action of heat on Wood’s sarcomas. Acta Radiol 21: 577–582
Overgaard J (1978) The effect of local hyperthermia alone and in combination with radiation on solid tumors. In: Streffer C et al (eds) Cancer therapy by hyperthermia and radiation. Urban and Schwarzenberg, Baltimore, pp 49–61
Overgaard J (1981) Fractionated radiation and hyperthermia: experimental and clinical studies. Cancer 48, 1116–1123
Overgaard J (1983) Hyperthermic modification of the radiation response in solid tumors. In: Fletcher GH et al. (eds) Biological bases and clinical implications of tumor radioresistance. Masson, New York, 337–352
Overgaard J (1986) Hyperthermia as an adjuvant to radiotherapy. Review of the randomized multicenter studies of the European Society for Hyperthermie Oncology. Presented at the Hyperthermia Symposium, Strahlenklinik Universitätsklinikum Essen, April 1986. Strahlenther Onkol (to be published)
Perez CA, Meyer JC (1985) Clinical experience with localized hyperthermia and irradiation. In: Overgaard J (ed) Proceedings of the 4th international symposium on hyperthermie oncology, vol 2, review lectures, symposium summaries and workshop summaries. Taylor and Francis, London, pp 181–198
Perez CA, Nussbaum G, Emami B, Vongerichten D (1983) Clinical results of irradiation combined with local hyperthermia. Cancer 52: 1597–1603
Perez CA, Emami B, Nussbaum GH (1984 a) Regional (deep) heating, clinical studies in progress. Front Radiat Ther Oncol 18: 108–125
Perez CA, Emami B, Vongerichten D (1984b) Clinical results with irradiation and local microwave hyperthermia in cancer therapy. In: Overgaard J (ed) Proceedings of the 4th international symposium on hyperthermic oncology, vol 1, summary papers. Taylor and Francis, London, pp 398–402
Pomp H (1978) Clinical application of hyperthermia in gynecological malignant tumors. In: Streffer C et al (eds) Cancer therapy by hyperthermia and radiation. Urban and Schwarzenberg, Baltimore, pp 326–327
Reinhold HS, Wike-Hooley JL, van den Berg AP, van den Berg-Blok A (1984) Environmental factors, blood flow and microcirculation. In: Overgaard J (ed) Proceedings of the 4th international symposium on hyperthermic oncology, vol 2. Review lectures, symposium summaries and workshop summaries. Taylor and Francis, London, pp 41–52 (1984)
Rhodenburg GL, Prime F (1921) The effect of combined radiation and heat on neoplasms. Arch Surg 2: 116–129
Ruggera PS, Kantor G (1984) Development of a family of RF helical coil applicators which produce transversely uniform axially distributed heating in cylindrical fat-muscle phantoms. IEEE Trans Biomed Eng 31: 98–105
Sapareto SA, Dewey WC (1984) Thermal dose determination in cancer therapy. Int J Radiat Oncol Biol Phys 10: 787–796
Sapozink MD, Gibbs FA, Gates KS, Stewart JR (1984) Regional hyperthermia in the treatment of clinically advanced deep seated malignancy: results of a pilot study employing an annular array applicator. Int J Radiat Oncol Biol Phys 10: 775–786
Sapozink MD, Gibbs FA, Thomson JW, Eltringham JR, Steward JR (1985) A comparison of deep regional hyperthermia from an annular array and a concentric coil in the same patients. Int J Radiat Oncol Biol Phys 11: 179–190
Sauer R, Herbst M (1984) Hyperthermia for overcoming radioresistant-clinical experiences. Tumor Diag Therap 5: 116–121
Schmidt HE (1909) Zur Röntgenbehandlung tiefliegender Tumoren. Fortschr Roentgenstr 14: 134–136
Scott RS, Johnson RJR, Kowal H, Krishnamesetty RM, Story K, Clay L (1983) Hyperthermia in combination with radiotherapy: a review of five years experience in the treatment of superficial tumors. Int J Radiat Oncol Biol Phys 9: 1327–1333
Scott RS, Clay C, Storey KV, Johnson JR (1985) Transient microwave induced neurosensory reactions during superficial hyperthermia treatment. Int J Radiat Oncol Biol Phys 11: 561–566
Selawry OS, Carlson JC, Moore GE (1958) Tumor response to ionizing rays at elevated temperatures. Am J Roentgenol 833–839
Sim DA, Dewhirst MW, Oleson JR, Grochowski KJ (1984) Estimating the therapeutic advantage of adequate heat. In: Overgaard J (ed) Proceedings of the 4th International Symposium of Hyper-thermic Oncology, vol 1. Summary papers. Taylor and Francis, London, pp 359–362
Stauffer PR, Cetas TC, Jones RC (1982) System for producing localized hyperthermia in tumors through magnetic induction heating of ferromagnetic implants. Nat Cancer Inst Monogr 61: 483–487
Stewart JR, Gibbs FA, Sapozink MD, Gates KS (1984) Regional hyperthermia using an annular phased array system. Front Radiat Ther Onc 18: 103–107
Storm FK (1983) Hyperthermia in cancer therapy. Hall Medical, Boston
Storm FK, Silberman AW (1984) Clinical thermochemotherapy: a controlled trial in advanced cancer patients. Cancer 53: 863–868
Storm FK, Harrison WH, Elliot RS, Halzitheofilou C, Morton DL (1979 a) Human hyperthermic therapy: relation between tumor type and capacity to induce hyperthermia by radiofrequency. Am J Surg 138: 170–174
Storm FK, Harrison WH, Elliott RS, Morton DL (1979b) Normal tissue and solid tumor effects of hyperthermia in animal models and clinical trials. Cancer Res 39: 2245–2251
Storm FK, Harrison WH, Elliot RS, Morton DL (1980) Hyperthermic therapy for human neo-plasmas: thermal death time. Cancer 46: 1849–1854
Storm FK, Elliott RS, Harrison WH, Kaiser LR, Morton DL (1981) Radiofrequency hyperthermia of advanced human sarcomas. J Surg Oncol 17: 91–98
Storm FK, Harrison WH, Elliott RS, Silberman AW, Morton DL (1982 a) Thermal distribution of magnetic loop induction in phantoms and animals: effect of the living state and velocity of heating. Int J Radiat Oncol Biol Phys 8: 865–871
Storm FK, Kaiser LR, Goodnight JE, Harrison WH, Elliott RS, Gomes AS, Morton DL (1982b) Thermo-chemotherapy for melanoma metastases in liver. Cancer 49: 1243–1248
Streffer C (1985) Mechanism of heat injury. In: Overgaard J (ed) Hyperthermic oncology. vol 2, review Lectures, Symposium summaries and workshop summaries. Proceedings of the 4th international symposium on hyperthermic oncology. Taylor and Francis, London, pp 213–222
Streffer C, van Beuningen D (1983) Hyperthermia as a radiosensitizing and cytotoxic agent: cell biological and biochemical considerations. Verh Dtsch Krebsges 4: 87–97
Streffer C, van Beuningen D, Dietzel F, Roettinger E, Robinson JE, Scherer E, Seeber S, Trott KR (eds) Cancer therapy by hyperthermia and radiation. Proceedings of the 2nd international symposium, Essen, June 2–4, 1977.
Strohbehn JW (1982) Theoretical temperature distributions for soleoidal-type hyperthermia systems. Med Phys 9: 673–682
Strohbehn JW, Douple EB, Coughlin CI (1984) Interstitial microwave antenna array system for hyperthermia. Front Radiat Ther Oncol 18: 70–74
Suit HD (1982) Potential for improving survival rates for the cancer patient by increasing the efficacy of treatment of the primary lesion. Cancer 50: 1227–1234
Suit H, Gerweck LE (1979) Potential for hyperthermia and radiation therapy. Cancer Res 39: 2290–2298
The Combination of Hyperthermia and Radiation: Clinical Investigations 135
Teilhaber A (1913) Zur Frage von der operationslosen Behandlung des Carcinoms. Berl klin Wschr 50: 348–349
Turner PF (1982) Deep heating of cylindrical or elliptical tissue masses. In: Third int. symp: cancer therapy by hyperthermia, drugs and radiation. Natt Cancer Inst Monogr 61: 493–495
Turner PF (1984) Regional hyperthermia with an annular phased array. IEEE Trans Biomed Eng 31: 106–114
Noell KT RU, Woodward KT, Worde BT, Fishburn RI, Miller LS (1980) Microwave-induced local hyperthermia in combination with radiotherapy of human malignant tumors. Cancer 45: 638–646
Urano M, Rice LC, Montoya V (1982) Studies on fractionated hyperthermia in experimental animal systems II. Response of mutine tumors to two or more doses. Int J Radiat Oncol Biol Phys 8: 227–233
Valdagni R, Gosetti G, Amicheti M, Pani G, Knapp DS (1985) Irradiation and hyperthermia in N3 metastatic meck modes: clinical results with an analysis of treatment parameters. Strahlentherapie 161: 551–552
van Beuningen D, Streffer C (1985) Die Hyperthermie. In: Heuck F, Scherer E (eds) Handbuch der medizinischen Radiologie, vol XX. Springer Berlin Heidelberg New York Tokyo, pp 641–681 ( 1985 )
von Ardenne M (1970/71) Theoretische und experimentelle Grundlagen der Krebs-MehrschrittTherapie, 2nd ed. VEB Verlag Volk und Gesundheit, Berlin
van der Zee J, van Rhoon GC, Wike-Hooley JL, van den Berg AP, Reinhold HS (1984) Thermal enhancement of radiotherapy in breast carcinoma. In: Overgaard J (ed) Proceedings of the 4th international symposium on hyperthermic oncology, vol 1. Summary papers. Taylor and Francis, London, pp 345–348
van der Zee, van Rhoon GC, Wike-Hooley JL (1985) Clinical derived dose effect relationship for hyperthermia given in combination with low dose radiotherapy. Br J Radiology 58: 243–250
Weischedel U, Wieland C (1981) Kombinierte Wärme-Strahlentherapie maligner Tumoren. Onkologie 4: 6–9
Westermark F (1898) Über die Behandlung des ulcerierenden Cervixcarcinoms mittels konstanter Wärme. Zentralbl Gynaek 22: 1335–1339
Westermark N (1927) The effect of heat upon rat tumors. Scand Arch Physiol 52: 257–322
Westra A, Dewey WC (1971) Heat shock during the cell cycle of Chinese hamster cells in vitro. Int J Radiat Biol 19: 467–477
Wiegant FAC, Tuyl M, Linnemans WAM (1985) Calmodulin inhibitors potentiate hyperthermic cell killing. Int J Hyperthermia 1: 157–169
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Molls, M., Scherer, E. (1987). The Combination of Hyperthermia and Radiation: Clinical Investigations. In: Streffer, C. (eds) Hyperthermia and the Therapy of Malignant Tumors. Recent Results in Cancer Research, vol 104. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82955-0_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-82955-0_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-82957-4
Online ISBN: 978-3-642-82955-0
eBook Packages: Springer Book Archive