Managing Side-Effects in Radiotherapy with Regard to the Gastrointestinal Tract

  • L. Franzén
  • U. Hellsing
  • R. Henriksson
  • B. Littbrand
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 108)


Radiation treatment of neoplasms in the gastrointestinal tract is associated with a high frequency of side-effects. In the upper gastrointestinal tract the direct effect of irradiation is erythema, plaque formation, and in severe cases ulceration and bleeding [2]. The injuries are aggravated by the radiation damage to salivary glands and by the secondary decreased salivary flow [4, 8]. The altered salivation is also followed by dental caries. It is obvious that the patients suffer from discomfort in speaking, mastication, and swallowing.


Dental Caries Parotid Gland Aluminum Hydroxide Salivary Flow Tongue Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Andersson H, Bosaeus I, Nyström C (1978) Bile salt malabsorption in the radiation syndrome. Acta Radiol [Oncol] 17: 312CrossRefGoogle Scholar
  2. 2.
    Beumer I, Curtis T, Harrison RE (1979) Radiation therapy of the oral cavity: sequelae and management. Head Neck Surg 1: 301PubMedCrossRefGoogle Scholar
  3. 3.
    Chary S, Thomson DH (1984) A clinical trial evaluating cholestyramine to prevent diarrhea in patients maintained on low fat diets during pelvic radiation therapy. Int J Radiat Oncol Biol Phys 10: 1885PubMedCrossRefGoogle Scholar
  4. 4.
    Eneroth CM, Henriksson CO, Jakobsson PA (1972) Effect of fractionated radiotherapy on salivary gland function. Cancer 30: 1147PubMedCrossRefGoogle Scholar
  5. 5.
    Franzen L, Carlsöö B, Henriksson R, Littbrand B, Löfroth PO (1987) Evaluation of radiotherapy of tongue cancer. (Submitted)Google Scholar
  6. 6.
    Larsson LG, Seelig I (1976) Malignant nasopharyngeal tumours. Result of radiation therapy. Acta Radiol [Oncol] 15: 209CrossRefGoogle Scholar
  7. 7.
    Martin F, Farley A, Gagnon M, Bensemona D (1982) Comparison of the healing capacities of sucralfate and limetidine in the short-term treatment of duodenal ulcer. Gastroenterology 82: 401PubMedGoogle Scholar
  8. 8.
    Mossman KL, Shatzman AR, Chencharick JD (1981) Effects of radiotherapy on human parotid saliva. Radiat Res 88: 403PubMedCrossRefGoogle Scholar
  9. 9.
    Tamawski A (1984) Sucralfate: Is it more than just a barrier? Cytoprotection. Cur Concept Gastroenterol 1: 5Google Scholar
  10. 10.
    Tobiasson P, Stenstam M (1985) Effects of sucralfate and cholestyramine on bile acid absorption. Gastroenterology 88: 393Google Scholar

Copyright information

© Springer-Verlag Berlin·Heidelberg 1988

Authors and Affiliations

  • L. Franzén
    • 1
  • U. Hellsing
    • 1
  • R. Henriksson
    • 1
  • B. Littbrand
    • 1
  1. 1.Department of OncologyUniversity of UmeåUmeåSweden

Personalised recommendations