Zusammenfassung
Ich möchte aus Zeitgründen das mir gestellte Thema „Glukosestoffwechsel bei Leberkrankheiten“ etwas einengen. Ich werde zunächst die Wechselwirkungen von Diabetes und Leberkrankheiten analysieren und sodann Änderungen der hormonalen Regulation des Kohlenhydratstoffwechsels bei Lebererkrankungen diskutieren. Abschließend werde ich über neuere Untersuchungen aus der Göttinger Medizinischen Klinik über die Wirkung von Proinsulin auf den Kohlenhydratstoffwechsel der Leber und die sich hieraus möglicherweise ergebenden therapeutischen Aspekte berichten.
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Literatur
Naunyn B (1898) Der Diabetes mellitus. In: Nothnagels Handbuch-Spez Path Ther, Band VII, 1. Aufl, Wien
Creutzfeldt W, Frerichs H, Sickinger K (1970) Liver diseases and diabetes mellitus. In: Popper H, Schaffner F (eds) Progress in liver disease, Vol
Grune & Stratton, New York, pp 371–407
Megyesi C, Samols E, Marks V (1967) Glucose tolerance and diabetes in chronic liver disease. Lancet 2: 1051–1056
Iwasaki Y, Ohkubo A, Kajinuma H, Akanuma Y, Kosaka K (1978) Degradation and secretion of insulin in hepatic cirrhosis. J Clin Endocrinol Metab 47: 774–779
Niederau C, Berger M, Stremmel W, Starke A, Strohmeyer G, Ebert R, Siegel E, Creutzfeldt W (1984) Hyperinsulinaemia in non-cirrhotic haemochromatosis: impaired hepatic insulin degradation? Diabetologia 26: 441–444
Kasperska-Czyzykowa T, Heding LG, Czyzyk A (1982) Hyperproinsulinaemia in patients with liver cirrhosis. Diabetes 31 (Suppl 2): 149a
Deacon CF, Conlon JM (1985) Measurement of circulating human proinsulin concentrations using a proinsulin-specific antiserum. Diabetes 34: 491–497
Ballmann M, Conlon JM, Creutzfeldt W, Deacon CF, Hartmann H (1985) The contribution of proinsulin to the hyperinsulinaemia of liver cirrhosis. Diabetes Research and Clinical Practice, Suppl 1. Elsevier, Amsterdam, S 33
Sotaniemi EA, Keinänen K, Lahtela JT, Arranto AJ, Kairaluoma M (1985) Carbohydrate intolerance associated with reduced hepatic glucose phosphorylating and releasing enzyme activities and peripheral insulin resistance in alcoholics with liver cirrhosis. J Hepatol 1: 277–290
Proietto J, Alford FP, Dudley FJ (1980) The mechanism of the carbohydrate intolerance of cirrhosis. J Clin Endocrinol Metab 51: 1030–1036
Leatherdale BA, Chase RA, Rogers J, Alberti KGMM, Davies P, Record CO (1980) Forearm glucose uptake in cirrhosis and its relationship to glucose tolerance. Clin Sci 59: 191–198
Riley WJ, McCann VJ (1981) Impaired glucose tolerance and growth hormone in chronic liver disease. Gut 22: 301–305
Bianchi L, Gerok W, Landmann L, Sickinger K, Stalder HA (eds) (1983) Liver in metabolic diseases. MTP Press, Lancaster
Keller U, Sonnenberg GE, Burckhardt D, Perruchoud A (1982) Evidence for an augmented glucagon dependence of hepatic glucose production in cirrhosis of the liver. J Clin Endocrinol Metab 54: 961–968
Bachmann W, Haslbeck M, Bottger I, Hepp KD, Mehnert H (1979) Reduced insulin binding to hepatic plasma membranes in D-galactosamine-treated rats. Diabetologia 17: 101–109
Taylor R, Heine RJ, Collins J, James OFW, Alberti KGMM (1985) Insulin action in cirrhosis. Hepatology 5: 64–71
Teng CS, Ho PWM, Yeung RTT (1982) Down-regulation of insulin receptors in postnecrotic cirrhosis of liver. J Clin Endocrinol Metab 55: 524–530
Oversen J, Vilstrup H, Tygstrup N (1984) Kinetics of glucose metabolism in relation to insulin concentrations in patients with alcoholic cirrhosis and in healthy persons. Gastroenterology 87: 1138–1143
Willms B, Appels A, Söling H-D, Creutzfeldt W (1969) Lack of hypoglycemic effect of bovine proinsulin in eviscerated, hepatectomized rats. Horm Metab Res 1: 199–200
Hartmann H, Kramer U, Creutzfeldt W (1985) Differential effects of pro-insulin and insulin on hypoglycaemia and hepatic glycogenolysis in the rat. Diabetes Research and Clinical Practice, Suppl 1. Elsevier, Amsterdam, S 226
Probst I, Hartmann H, Jungermann K, Creutzfeldt W (1985) Insulin-like action of proinsulin on rat liver carbohydrate metabolism in vitro. Diabetes 34: 415–419
Revers RR, Henry R, Schmeiser L, Kolterman O, Cohen R, Bergenstal R, Polonsky K, Jaspan J, Rubenstein A, Frank B, Galloway J, Olefsky JM (1984) The effects of biosynthetic human proinsulin on carbohydrate metabolism.. Diabetes 33: 762–770
Hearn AG, Billing B, Sherlock S (1953) Response of the liver to insulin; hepatic vein catheterization studies in man. In: Ciba Foundation Colloquia on Endocrinology, Band VI, Hormonal factors in carbohydrate metabolism. Churchill, London, pp 250–260
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© 1987 Springer-Verlag Berlin · Heidelberg
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Creutzfeldt, W. (1987). Glukosestoffwechsel bei Leberkrankheiten. In: Seidel, D., Lang, H. (eds) Funktion und Funktionsdiagnostik der Leber. Zusammenarbeit von Klinik und Klinischer Chemie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82882-9_7
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DOI: https://doi.org/10.1007/978-3-642-82882-9_7
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