Use of Tissucol (Tisseel) in Maxillofacial Surgery
Fibrin glue (Tissucol) is a biological substance derived from human donor plasma by means of cryoprecipitation, producing a highly concentrated solution of fibrinogen and other cryoglobulins. This fibrinogen contains the coagulation factor XIII and in the presence of both thrombin and calcium is a filamentous precipitate of highly adhesive fibrin. In this paper we present the mode of action of Tissucol and its method of preparation. We also present and discuss the way in which Tissucol effects tissue repair and the effectiveness of fibrinogen in this process. The indications for proper use of Tissucol are a consequence of this healing process and we report on the use of Tissucol in maxillofacial surgery in tegumentary lesion repair, in plastic surgery and in bone surgery.
Key wordsFibrin glue maxillofacial surgery Tissucol
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