Fast-Atom Bombardment Mass Spectra of O-Isopropyl Oligodeoxyribonucleotide Triesters
Oligodeoxyribonucleotides with alkylated internucleotide phosphate moieties are not only resistant to degradation by nucleases, but are also incorporated by cells, thus targeting this class of compounds for potential use as antiviral drugs and drug-carriers . Subsequent to synthesis, these compounds must first be analyzed to verify the correctness of chemical structure. Fast-atom bombardment (FAB) mass spectrometry  has been used to examine some unprotected [3–7] and protected [8–10] oligonucleotides. Herein is reported the application of FAB mass spectrometry to the determination of several features characteristic of the primary structure of synthetic Oisopropyl oligodeoxyribonucleotide triesters, which are now accessible by means of recently reported methodology .
KeywordsAntiviral Drug Xenon Atom Lower Mass Region Alkylated Moiety Moderate Abundance
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