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Chemotherapy with or Without Anticoagulation as Initial Management of Patients with Operable Colorectal Cancer: A Prospective Study with at Least 5 Years Follow-up

  • Conference paper
Preoperative (Neoadjuvant) Chemotherapy

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 103))

Abstract

Colorectal carcinoma (CRCa) is the most frequently encountered malignant neoplasm in the United States, which ultimately kills almost exclusively because of systemic dissemination in more than 50% of those manifesting the disease (Welch and Donaldson 1974). It is obvious that better means for systemic control of this disease are needed. The design of this study was influenced by (a) dissatisfaction with the results of postoperative adjuvant chemotherapy in CRCa, (b) the many theoretical considerations along with some experimental and clinical studies suggesting that chemotherapy might become more effective if given before operation rather than after it, and (c) evidence suggesting that anticoagulation might hinder tumor growth. This study was recently reported in detail (Papaioannou et al. 1985) and is presented here in shortened form.

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References

  • Agostino D (1970) Enhancement of pulmonary metastasis following intravenous infusion of a suspension of ellagic acid. Tumori 56: 29–35

    PubMed  CAS  Google Scholar 

  • Agostino D, Cliffton EE (1973) Decrease in pulmonary métastases: potentiation of nitrogen mustard effect by heparin and fibrinolysin. Ann Surg 157: 400–408

    Article  Google Scholar 

  • Ambrus JL, Ambrus CM, Pickern J, Solder S, Bross I (1975) Hématologic changes and thromboembolic complications in neoplastic disease and their relationship to metastasis. J Med 6: 433–458

    PubMed  CAS  Google Scholar 

  • Dixon JW, Longmire WP, Holden WD (1971) The use of triethylene triophosphamide: an adjuvant to surgical treatment of gastric and colorectal cancer: ten-year follow-up. Ann Surg 173: 26–39

    Article  PubMed  CAS  Google Scholar 

  • Drapkin RL, Gee TS, Dowling MD, Arlin Z, McKenzie S, Kempin S, Clarkson B (1978) Prophylactic heparin therapy in acute promyelocytic leukemia. Cancer 41: 2484–2490

    Article  PubMed  CAS  Google Scholar 

  • Dwight RW, Humphrey EW, Higgins GA, et al. (1973) FUDR, an adjuvant to surgery of the large bowel. J Surg Oncol 5: 243–249

    Article  PubMed  CAS  Google Scholar 

  • Edlis HE, Goudsmit A, Brindley C, Niemetz J (1976) Trial of heparin and cyclophosphamide (NSC-26271) in the treatment of lung cancer. Cancer Treat Rep 60: 575–578

    PubMed  CAS  Google Scholar 

  • Elias EG, Shulka SK, Mink I (1975) Heparin and chemotherapy in the management of inoperable lung cancer. Cancer 36: 129–136

    Article  PubMed  CAS  Google Scholar 

  • Gasic GJ, Gasic TB, Murphy S (1972) Antimetastatic effect of aspirin. Lancet 2: 932

    Article  PubMed  CAS  Google Scholar 

  • Grage T, Hill G, Cornell T, et al. (1979) Adjuvant chemotherapy in large bowel cancer: updated analysis of single-agent chemotherapy. In: Jones SE, Salmon SE (eds) Adjuvant therapy of cancer II. Grune and Stratton, New York

    Google Scholar 

  • Higgins GA, Lee LE, Dwight RW, Keehn RJ (1978) The case of adjuvant 5-fluorouracil in colorectal cancer. Cancer Clin Trials 1: 35–41

    Google Scholar 

  • Hilgard P, Thornes RD (1976) Anticoagulants in the treatment of cancer. Eur J Cancer 12: 755–762

    Article  Google Scholar 

  • Hoover HC, Ketcham AS (1975) Decreasing experimental metastasis formation with anticoagulation and chemotherapy. Surg Forum 26: 173–174

    PubMed  Google Scholar 

  • Hoover HC Jr, Ketcham AS, Millar RC, et al (1978) Osteosarcoma: improved survival with anticoagulation and amputation. Cancer 41: 2475–2480

    Article  PubMed  Google Scholar 

  • Lerner RG, Goldstein R, Cummings G (1971) Stimulation of human leukocyte thromboplastic activity by endotoxin. Proc Soc Exp Biol Med 138: 145–148

    PubMed  CAS  Google Scholar 

  • Michaels L (1974) The incidence and course of cancer in patients receiving anticoagulant therapy. J Med 5: 98–106

    PubMed  CAS  Google Scholar 

  • Papaioannou AN (1981) Perspectives in cancer research: preoperative chemotherapy for operable solid tumors. Eur J Cancer 17: 963–969

    Google Scholar 

  • Papaioannou AN, Polychronis A, Plataniotis G, Tsamouri M, Kozonis J, Nomicos J (1985) Chemotherapy as initial management of patients with operable colerectal cancer. In: Wagener DJ (ed) Chemotherapy preceding surgery or irradiation in cancer medicine. Liss, New York (in press).

    Google Scholar 

  • Ries J, Ludwig H, Appel W (1968) Anticoagulants in the radiation treatment of carcinoma of the female genitalia. Med Welt 38: 2042–2047

    PubMed  CAS  Google Scholar 

  • Rohwedder JJ, Sagastume E (1977) Heparin and polychemotherapy for treatment of lung cancer. Cancer Treat Rep 61: 1399–1401

    PubMed  CAS  Google Scholar 

  • Schabel FM (1975) Concepts for systemic treatment of micrometastases. Cancer 35: 15–24

    Article  PubMed  CAS  Google Scholar 

  • Schaeffer JR (1964) Interference in localization of I131 fibrinogen in rat tumors by anticoagulants. Am J Physiol 206: 573–579

    Google Scholar 

  • Schultz RM, Papamatheakis JD, Chirigos MA (1977) Interferon: an inducer of macrophage activation by polyanions. Science 197: 674–676

    Article  PubMed  CAS  Google Scholar 

  • Suemasu K (1970) Inhibitive effect of heparin and dextran sulfate on experimental pulmonary metastases. Gann 61: 125 Taylor I (1981) Studies on the treatment and prevention of colorectal liver métastases. Ann R Coll Surg Engl 63: 270–273

    Google Scholar 

  • Thornes RD (1972) Fibrin and cancer. Br Med J 1: 110

    Article  PubMed  CAS  Google Scholar 

  • Thornes RD (1974) Oral anticoagulant therapy of human cancer. J Med 5: 83–91

    PubMed  CAS  Google Scholar 

  • Waddell WR (19737) Chemotherapy for carcinoma of the pancreas. Surgery 74: 420

    PubMed  CAS  Google Scholar 

  • Welch JP, Donaldson GA (1974) Recent experiences in the management of cancer of the colon and rectum. Am J Surg 127: 258–266

    Article  PubMed  CAS  Google Scholar 

  • Williams JRB, Maugham E (1972) Treatment of tumor métastases by defibrination. Br Med J 3: 174

    Google Scholar 

  • Zacharski LR, Henderson WG, Rickles FR, Forman WB, Cornell CJ Jr, Forcier RJ, Harrower HW, Johnson RO (1979) Rationale and experimental design for the VA cooperative study of anticoagulation (warfarin) in the treatment of cancer. Cancer 44: 732–741

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, Mount Vernon Hospital, 12 North Seventh Avenue, Mount Vernon, NY, 10550, USA

    A. N. Papaioannou, A. P. Polychronis, J. A. Kozonis, J. Nomicos, M. Tsamouri, G. A. Plataniotis & J. K. Papageorgiou

Authors
  1. A. N. Papaioannou
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  2. A. P. Polychronis
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  3. J. A. Kozonis
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  4. J. Nomicos
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  5. M. Tsamouri
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  6. G. A. Plataniotis
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  7. J. K. Papageorgiou
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Editor information

Editors and Affiliations

  1. Cancer Control Agency of British Columbia, 600 West 10th Avenue, Vancouver, B.C., V5Z 4E6, Canada

    Joseph Ragaz M. D. , Pierre R. Band M. D.  & James H. Goldie M.D. ,  & 

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© 1986 Springer-Verlag Berlin Heidelberg

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Papaioannou, A.N. et al. (1986). Chemotherapy with or Without Anticoagulation as Initial Management of Patients with Operable Colorectal Cancer: A Prospective Study with at Least 5 Years Follow-up. In: Ragaz, J., Band, P.R., Goldie, J.H. (eds) Preoperative (Neoadjuvant) Chemotherapy. Recent Results in Cancer Research, vol 103. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82671-9_15

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  • DOI: https://doi.org/10.1007/978-3-642-82671-9_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-82673-3

  • Online ISBN: 978-3-642-82671-9

  • eBook Packages: Springer Book Archive

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