Changes of Vascular Pattern of Tumors and Surrounding Tissue During Different Phases of Metastatic Growth

  • R. Bassermann
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 100)


The vascular systems of metastases exhibit changes with increasing growth. These changes in the vascular systems depend on certain factors in the surrounding tissue, i. e., in the parent tissue of the metastases, and on the specific characteristics of the malignant tumor. These various factors are as follows:
  1. 1.

    Histological type of metastasis

  2. 2.

    Histological degree of differentiation

  3. 3.

    Rate of growth

  4. 4.

    Induction of stroma

  5. 5.

    Incidence of necrosis

  6. 6.

    Location of the organ

  7. 7.

    Preexisting vascular structures or, as the case may be, relationship to the vascular system in the host organ

The growth of malignant tumors — and this applies to metastases as well, of course — is inconceivable without their own vascular system, i. e., without neoangiogenesis in the tumor. There is no doubt that in practice every growing tumor sooner or later produces angiogenetic stimuli which lead to neoangiogenesis [9]. The process of angiogenesis in metastases does not begin immediately after the invasion of the first tumor cells into the host organ [2]. This may constitute a difference from angiogenesis in primary tumors, which mostly develop out of preneoplasia and which, already in that form, exhibit characteristic changes in the vascular system [10].


Liver Metastasis Vascular System Vascular Pattern Endothelial Proliferation Host Organ 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Ackerman NB (1979) The blood supply of experimental liver metastases. IV. Changes in vascularity with increasing tumor growth. Surgery 75: 589–596Google Scholar
  2. 2.
    Bassermann R (1984) Angiogenese and Vaskularisation in Metastasen. Verh Dtsch Ges Pathol 68: 124Google Scholar
  3. 3.
    Bassermann R, Rabes HM (1983) Angiogenesis in experimentally induced metastases. Verh Dtsch Krebs Ges 4: 853Google Scholar
  4. 4.
    Breedis C, Young G (1954) The blood supply of neoplasms in the liver. Am J Pathol 30: 969–985Google Scholar
  5. 5.
    Cudkowicz L, Armstrong JB (1953) The blood supply of malignant pulmonary neoplasms. Thorax 8: 152–156CrossRefGoogle Scholar
  6. 6.
    Denekamp J, Hobson B (1982) Endothelial-cell proliferation in experimental tumours. Br J Cancer 46: 711–720PubMedCrossRefGoogle Scholar
  7. 7.
    Endrich B, Oda T, Messmer K, Intaglietta M (1983) Besonderheiten der Mikrozirkulation in bösartigen Tumoren. In: Vaupel P, Hammersen F (eds) Mikrozirkulation in malignen Tumoren. Karger, Basel, pp 52–68Google Scholar
  8. 8.
    Folkman J (1974) Tumor angiogenesis factor. Cancer Res 34: 2109–2113PubMedGoogle Scholar
  9. 9.
    Folkman J (1984) Angiogenesis: initiation and modulation. In: NicolsonGL, MilasL (eds) Cancer invasion and metastasis: biologic and therapeutic aspects. Raven, New York, pp 201–208Google Scholar
  10. 10.
    Gimbrone MA, Gullino PM (1976) Angiogenic capacitiy of preneoplastic lesions of the murine mammary gland as a marker of neoplastic transformation. Cancer Res 36: 2611–2615PubMedGoogle Scholar
  11. 11.
    Gunduz N (1981) Cytokinetics of tumor and endothelial cells and vascularisation of lung metastases in C3H/He mice. Cell Tissue Kinet 14: 343–363PubMedGoogle Scholar
  12. 12.
    Lewis WH (1927) The vascular patterns of tumors. J Hopkins Hosp Bull 41: 156–162Google Scholar
  13. 13.
    Long DM (1979) Capillary ultrastructure in human metastatic brain tumors. J Neurosurg 51: 53–58PubMedCrossRefGoogle Scholar
  14. 14.
    Milne ENC, Margulis C, Noonan D, Stoughton JT (1967) Histologic type-specific vascular patterns in rat tumors. Cancer 20: 1635–1646PubMedCrossRefGoogle Scholar
  15. 15.
    Milne ENC (1967) Circulation of primary and metastatic pulmonary neoplasms. Am J Radiol 100: 603–609Google Scholar
  16. 16.
    Ogilvie WR, Blanding JD, Wood ML, Knisely WH (1964) The arterial surply to experimental metastatic VX 2 and XY tumors in rabbit lungs. Cancer Res 24: 1418–1424PubMedGoogle Scholar
  17. 17.
    Vaupel P, Frinak S, Bicher HI (1979) Heterogeneous PO2 and pH distribution in C2H mouse mammary carcinoma. (Manuskriptband) 4. Jahrestagung der Deutschen Gesellschaft für Mikrozirkulation, MainzGoogle Scholar
  18. 18.
    Warren BA (1979) The vascular morphology of tumors; in Peterson (ed) Tumor blood circulation. Angiogenesis, vascular morphology and blood flow in CRC Press, Boca Raton, pp 1–47Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • R. Bassermann
    • 1
  1. 1.PathologieKaufbeurenGermany

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