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Peptide Hormones in Lung Cancer pp 221–236Cite as

Genes and Gene Products Involved in Growth Regulation of Tumor Cells

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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 99))

Abstract

Protooncogenes, the cellular homologs of retroviral oncogenes, are cellular genes that control the growth and affect the differentiation of eukaryotic cells. Long before the discovery of viral oncogenes and their cellular homologs (Bishop 1983), it was clear that malignantly transformed cells were genetically altered with regard to their growth factor requirements for propogation in culture (Temin 1967, 1970). Moreover, the fact that cells transformed by oncogene transducing mammalian retroviruses were blocked for the binding of epidermal growth factor (DeLarco and Todaro 1978) and released transforming growth factors into the culture medium (Todaro et al. 1979, 1980; Marquardt et al. 1983) suggested early on that some viral oncogenes might be coding for or regulating the expression of such growth factors by infected cells. These observations have led to the proposal that transformed cells maintain autonomous growth by autocrine secretion (Sporn and Todaro 1980). Substance was added to such hypotheses by the recent finding that one oncogene, v-sis, was derived from a cellular growth factor gene, that for platelet-derived growth factor (PDGF) (Doolittle et al. 1983; Johnsson et al. 1984). Moreover, another viral oncogene, erb-B, was identified as a portion of the receptor gene for epidermal grwoth factor (EGF) (Downward et al. 1984; Ullrich et al. 1984). Evidence is accumulating that other oncogenes also code for portions of growth factor receptors or for proteins that affect the signal transmission from growth factor receptors to the nucleus. Analogous to the observation that certain combinations of peptide growth factors may have synergistic effects on cell growth properties, it was recently demonstrated that combinations of “complementary” oncogenes may act synergistically to transform a particular cell type (Land et al. 1983a, b).

This project has been funded, at least in part, with Federal funds from the Department of Health and Human Services, under contract number N01-CO-23909 with Litton Bionetics, Inc. The contents of this publication do not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endosement by the U. S. Government

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References

  • Anzano MA, Roberts AB, Smith JM, Sporn MB, De Larco JE (1983) Sarcoma growth factor from conditioned medium of virally transformed cells is composed of both type α and type β transforming growth factors. Proc Natl Acad Sci USA 80: 6264–6268.

    Article  PubMed  CAS  Google Scholar 

  • Bishop JM (1983) Cellular oncogenes and retroviruses. Annu Rev Biochem 52: 301–354.

    Article  PubMed  CAS  Google Scholar 

  • Bonner T, O’Brien SJ, Nash WG, Rapp UR, Morton CC, Leder P (1984) The human homologs of the raf (mil) oncogene are located on human chromosomes 3 and 4. Science 223: 71–74.

    Article  PubMed  CAS  Google Scholar 

  • Bonner TI, Kerby S, Sutrave P, Gunnell M, Mark GE, Rapp UR (1985) The structure and biological activity of the human homologues of the raf/mil oncogene. Mol Cell Biol (in press).

    Google Scholar 

  • Clemmons DR, Underwood LE, Van Wyk JJ (1981) Hormonal control of immunoreactive somatomedin production by cultured human fibroblasts. J Clin Invest 67: 10–19.

    Article  PubMed  CAS  Google Scholar 

  • Cochet C, Gill GN, Mersenholder J, Cooper JA, Hunter T (1984) C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity. J Biol Chem 259: 2553–2558.

    PubMed  CAS  Google Scholar 

  • Cole JM, Righi C de Toisne, Dissous C, Gegonne G, Stehelin D (1983) Molecular cloning of the avian acute transforming retrovirus MH2 reveals a novel cell derived sequence (v-mil) in addition to the myc oncogene. EMBO J 2: 2189–2194.

    Google Scholar 

  • De Larco JE, Todaro GJ (1978) Growth factors from murine sarcoma virus-transformed cells. Proc Natl Acad Sci USA 75: 4001–4005.

    Article  PubMed  Google Scholar 

  • Donner P, Greiser-Wilke I, Moelling K (1982) Nuclear localization and DNA binding of the transforming gene product of avian myelocytomatosis virus. Nature 296: 262–266.

    Article  PubMed  CAS  Google Scholar 

  • Doolittle RF, Hunkapiller MW, Good LE, Devare SG, Robbins KC, Aaronson SA, Antoniades HN (1983) Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. Science 221: 275–277.

    Article  PubMed  CAS  Google Scholar 

  • Downward J, Yarden Y, Mayes E, Scrace G, Totty N, Stockwell P, Ullrich A, Schlessinger J, Waterfield MD (1984) Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature 207: 521–527.

    Article  Google Scholar 

  • Finkel T, Cooper GM (1984) Detection of a molecular complex between ras proteins and transferrin receptor. Cell 136: 1115–1121.

    Article  Google Scholar 

  • Houselay MD (1984) A family of guanine nucleotide regulatory proteins. Trends Biochem Sci 9: 39–45.

    Article  Google Scholar 

  • Ihle JN, Weinstein Y (1983) Interleukin 3: Regulation of a lineage of lymphoid cells characterized by the expression of 20 hydroxysteroid dehydrogenase. In: Watson JD, Marbrook J (eds) Recognition and regulation in cell-mediated immunity. Dekker, New York (in press).

    Google Scholar 

  • Jacobs S, Sahyoun NE, Saltiel AR, Cuatrecasas P (1983) Phorbol esters stimulate the phosphorylation of receptors for insulin and somatomedin C. Proc Natl Acad Sci USA 80: 6211–6213.

    Article  PubMed  CAS  Google Scholar 

  • Jansen HW, Ruckert B, Lurz R, Bister K (1983 a) Two unrelated cell-derived sequences in the genome of avian leukemia and carcinoma inducing retrovirus MH2. EMBO J 2: 1969–1975.

    PubMed  CAS  Google Scholar 

  • Jansen HW, Patschinsky T, Bister KJ (1983 b) Avian oncovirus MH2: Molecular cloning of proviral DNA and structural analysis of viral RNA and protein. J Virol 48: 61–73.

    PubMed  CAS  Google Scholar 

  • Jansen H, Lurz R, Bister K, Bonner TI, Mark GE, Rapp UR(1984) Homologous cell-derived oncogenes in avian carcinoma virus MH2 and murine sarcoma virus 3611. Nature 307: 281–284.

    Article  PubMed  CAS  Google Scholar 

  • Johnsson A, Heldin CH, Wasteson A, Westermark B, Deuel TF, Huang JS, Seeburg DH, Gray E, Ullrich A, Scrace G, Stroobant P, Waterfield MD (1984) The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor. EMBO J (in press).

    Google Scholar 

  • Kan NC, Flordellis CS, Garon CF, Duesberg PH, Papas TS (1983) Avian carcinoma virus MH2 contains a transformation specific sequence, mht, and shares the myc sequence with ML29, CMII and OK10 viruses. Proc Natl Acad Sci USA 80: 6566–6570.

    Article  PubMed  CAS  Google Scholar 

  • Kan NC, Flordellis CS, Mark GE, Duesberg PH, Papas TS (1984) A common onc gene sequence transduced by avian carcinoma virus MH2 and murine sarcoma virus 3611. Science 223: 813–816.

    Article  PubMed  CAS  Google Scholar 

  • Kelly K, Cochran BH, Stiles CD, Leder P (1983) Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell 35: 603–610.

    Article  PubMed  CAS  Google Scholar 

  • Land H, Parada LF, Weinberg RA (1983 a) Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature 304: 596–602.

    Article  PubMed  CAS  Google Scholar 

  • Land H, Parada LF, Weinberg RA (1983 b) Cellular oncogenes and multistep carcinogenesis. Science 222: 771–778.

    Article  PubMed  CAS  Google Scholar 

  • Little CD, Nau MM, Carny DN, Gazdan AF, Minna JD (1984) Amplification and expression of the c-myc oncogene in human lung cancer cell lines. Nature 306: 194–196.

    Article  Google Scholar 

  • Mark GE, Rapp UR (1984) Primary structure of v-raf: Relatedness to the src family of oncogenes. Science 224: 285–288.

    Article  PubMed  CAS  Google Scholar 

  • Mark J, Dahlenfors R, Ededahl C, Stenman G (1980) The mixed salivary gland tumor — a normally benign human neoplasm frequently showing specific chromosomal abnormalities. Cancer Genet Cytogenet 2: 231.

    Article  Google Scholar 

  • Marquardt H, Hunkapiller MW, Hood LE, Twardzik DR, De Larco JE, Stephenson JR, Todaro GJ (1983) Transforming growth factors produced by retro virus-transformed rodent fibroblasts and human melanoma cells: amino acid sequence homology with epidermal growth factor. Proc Natl Acad Sci USA 80: 4684–4688.

    Article  PubMed  CAS  Google Scholar 

  • Michell B (1984) Oncogenes and inosito lipids. Nature 308: 770.

    Article  PubMed  CAS  Google Scholar 

  • Moelders H, Defesche J, Müller D, Bonner TI, Rapp UR, Müller R (1985) Integration of transfected LTR sequences into the c-rafproto-oncogene: activation by promoter insertion. EMBO J (in press).

    Google Scholar 

  • Moelling K, Heiman B, Bunte T, Rapp UR (1984) Association of a ser/thr-specific protein kinase with purified gag-mil and gag-raf proteins in vitro. Nature 312: 558–561.

    Article  PubMed  CAS  Google Scholar 

  • Nishizuka Y (1984) The role of protein kinase C in cell surface signal transduction and tumor promotion. Nature 308: 693–698.

    Article  PubMed  CAS  Google Scholar 

  • Papkoff J, Lai MH, Hunter T (1983) Analysis of v-mos encoded proteins in cells transformed by several related murine sarcoma viruses. In: Scolnick EM, Levine AJ (eds) tumor viruses and differentiation. (UCLA Symposia on molecular and cellular biology, new series, vol 5) Liss, New York, pp 121–134.

    Google Scholar 

  • Pledger WJ, Stiles CD, Antoniades HN, Scher CD (1977) Induction of DNA synthesis in BALB/c 3T3 cells by serum components: reevaluation of the commitment process. Proc Natl Acad Sci USA 74: 4481–4485.

    Article  PubMed  CAS  Google Scholar 

  • Rapp UR, Todaro GJ (1978 a) Generation of oncogenic type C viruses derived from C3H mouse cells in vivo and in vitro. Proc. Natl Acad Sci USA 75: 2468–2472.

    Article  PubMed  CAS  Google Scholar 

  • Rapp UR, Todaro GJ (1978 b) Generation of new mouse sarcoma viruses in cell culture. Science 201: 821–824.

    Article  PubMed  CAS  Google Scholar 

  • Rapp UR, Todaro GJ (1980) Generation of oncogenic mouse type C viruses: In vitro selection of carcinoma-inducing variants. Proc Natl Acad Sci USA 77: 624–628.

    Article  PubMed  CAS  Google Scholar 

  • Rapp UR, Reynolds FH Jr, Stephenson JR (1983 a) New mammalian transforming retrovirus: Demonstration of a polyprotein gene product. J Virol 45: 914–924.

    PubMed  CAS  Google Scholar 

  • Rapp UR, Goldsborough MD, Mark GE, Bonner TI, Groffen J, Reynolds FH Jr, Stephenson JR (1983 b) Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus. Proc Natl Acad Sci USA 80: 4218–4222.

    Article  PubMed  CAS  Google Scholar 

  • Rapp UR, Reynolds FH Jr, Stephenson JR (1984) Isolation or new mammalian type C transforming viruses. In: Pearson ML, Sternberg NL (eds) Gene transfer and cancer. Raven, New York, pp 169–177.

    Google Scholar 

  • Robbins KC, Devare SG, Aaronson SA (1981) Molecular cloning of integrated simian sarcoma virus: genome organization of infectious DNA clones. Proc Natl Acad Sci USA 78: 2918–2922.

    Article  PubMed  CAS  Google Scholar 

  • Ruley HE (1983) Adenovirus early region 1 A enables viral and cellular transforming gnes to transform primary cells in culture. Nature 304: 602–606.

    Article  PubMed  CAS  Google Scholar 

  • Santos E, Martin-Zanca D, Reddy EP, Pierotti MA, Delia Porta G, Barbacid M (1984) Malignant activation of a k-ras oncogene in lung carcinoma but not in normal tissue of the same patient. Science 223: 661–664.

    Article  PubMed  CAS  Google Scholar 

  • Schultz A, Oroszlan S (1984) Myristylation of gag-onc fusion proteins in mammalian transforming retroviruses. Virology 133: 431–437.

    Article  PubMed  CAS  Google Scholar 

  • Sporn MB, Todaro GJ (1980) Autocrine secretion and malignant transformation of cells. N Engl J Med 303: 878–880.

    Article  PubMed  CAS  Google Scholar 

  • Stiles CED, Capone GT, Scher CD, Antoniades HN, Van Wyk JJ, Pledger WJ (1979) Dual control of cell growth by somatomedins and platelet-derived growth factor. Proc Natl Acad Sci USA 76: 1279–1283.

    Article  PubMed  CAS  Google Scholar 

  • Sutrave P, Bonner TI, Rapp UR, Jansen HW, Patschinsky T, Bisten K (1984) Nucleotide sequence of avian retroviral oncogene v-mil: homologue of murine retroviral oncogene v-raf Nature 309: 85–88.

    Article  PubMed  CAS  Google Scholar 

  • Temin HM (1967) Control by factors in serum of multiplication of uninfected cells and cells infected and converted by avian sarcoma viruses. In: Growth regulating substances for animal cells in cultures. Wistar Institute, Philadelphia, pp 103–116 (Wistar symposium monographs, no.7).

    Google Scholar 

  • Temin HM (1970) Control of multiplication of uninfected rat cells and rat cells converted by murine sarcoma virus. J Cell Physiol 75: 107–120.

    Article  PubMed  CAS  Google Scholar 

  • Todaro GJ, De Larco JE, Marquardt H, Bryant ML, Sherwin SA, Sliski AH (1979) Polypeptide growth factors produced by tumor cells and virustransformed cells: a possible growth advantage for the producter cells. In: Sato GH, Ross R (eds) Hormones and cell culture, Book A. Cold Spring Harbor Press, New York, pp 113–127 (Cold Spring Harbor conferences on cell proliferation, vol 6).

    Google Scholar 

  • Todaro GJ, Fryling C, De Larco JE (1980) Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal grwoth factor receptors. Proc Natl Acad Sci USA 77: 5258–5262.

    Article  PubMed  CAS  Google Scholar 

  • Twardzik DR, Todaro GJ, Marquardt H, Reynolds FH Jr, Stephenson JR (1982) Transformation induced by Abelson murine leukemia virus involves Production of a polypeptide growth factor. Science 216: 894–896.

    Article  PubMed  CAS  Google Scholar 

  • Ullrich A, Coussens L, Hayflick JS, Dull TJ, Gray A, Tarn AW, Lee J, Yarden Y, Libermann TA, Schlessinger J, Downward J, Mayes ELV, Whittle N, Waterfied MD, Seeburg PH (1984) Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature 309: 418–425.

    Article  PubMed  CAS  Google Scholar 

  • Waterfield MD, Scrace T, Whittle N, Stroobant P, Johnsson A, Wasteson A, Westermark B, Heldin C-H, Huang JS, Deuel TF (1983) Platelet-derived growth factor is structurally related to the putative transforming protein p28 of simian sarcoma virus. Nature 304: 35–39.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick Cancer Research Facility, Frederick, MD, 21701, USA

    U. R. Rapp, T. I. Bonner, K. Moelling, H. W. Jansen, K. Bister & J. Ihle

Authors
  1. U. R. Rapp
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  2. T. I. Bonner
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  3. K. Moelling
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  4. H. W. Jansen
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  5. K. Bister
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  6. J. Ihle
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Editors and Affiliations

  1. Zentrum für Innere Medizin Medizinische Klinik und Poliklinik Schwerpunkt Hämatologie, Onkologie, Immunologie, Klinikum der Philipps-Universität Marburg, Baldingerstrasse, 3550, Marburg, Deutschland

    Klaus Havemann

  2. Department of Pathology, Dartmouth Medical School, Hanover, NH, 03756, USA

    George Sorenson MD

  3. Klinik Bergisch-Land, Im Saalscheid 5, 5600, Wuppertal-Ronsdorf 21, Deutschland

    Claus Gropp

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© 1985 Springer-Verlag Berlin Heidelberg

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Rapp, U.R., Bonner, T.I., Moelling, K., Jansen, H.W., Bister, K., Ihle, J. (1985). Genes and Gene Products Involved in Growth Regulation of Tumor Cells. In: Havemann, K., Sorenson, G., Gropp, C. (eds) Peptide Hormones in Lung Cancer. Recent Results in Cancer Research, vol 99. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82533-0_24

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  • DOI: https://doi.org/10.1007/978-3-642-82533-0_24

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