Techniques for Avoiding Surgical Complications in Chemotherapy-Treated Cancer Patients
With the development of more effective antineoplastic drugs for the treatment of solid malignant tumors, the use of systemic chemotherapy in the perioperative period has become increasingly attractive. Strategies have evolved for administering chemotherapy preoperatively to render large tumors more easily resected, intraoperatively in isolation-perfusion systems (often in combination with hyperthermia), and postoperatively as an adjuvant or to treat residual disease. It is possible, however, that the benefits of perioperative chemotherapy may be offset by an increase in the incidence of complications, particularly with respect to wound healing. The well-known toxic effects of chemother-apeutic agents on actively replicating normal cells suggest that antineoplastic drugs could easily lead to wound problems such as infection or dehiscence.
KeywordsWound Healing Vascular Access Nitrogen Mustard Solid Malignant Tumor PTFE Graft
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- Cohen SC, Gabelnick HL, Johnson RK, Goldin A (1975a) Effects of antineoplastic agents on wound healing in mice. Surgery 78:238–244Google Scholar
- Jones TE, Newell ET, Brubaker RE (1941) The use of alloy steel wire in the closure of abdominal wounds. Surg Gynecol Obstet 72:1056–1059Google Scholar
- Raaf JH (1984a) Vascular access for chemotherapy. In: Waltzer WC (ed) Vascular Access Surgery chap 14. Grune and Stratton, New York, pp 161–192Google Scholar
- Raaf JH (1984b) Two Broviac catheters for intensive long-term support of cancer patients. Surg Gynecol Obstet 158:173–176Google Scholar
- Rosen G, Caparros B, Huvos AG, Kosloff C, Nirenberg A, Cacavio A, Marcove R, Lane T, Mehta B, Urban C (1982) Preoperative chemotherapy for osteogenic sarcoma: selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy. Cancer 49:1221–1230PubMedCrossRefGoogle Scholar
- Staley CJ, Trippel OH, Preston FW (1961) Influence of 5-fluorouracil on wound healing. Surgery 49:450–453Google Scholar