Preoperative Adjuvant Chemotherapy (Neoadjuvant) for Carcinoma of the Breast: Rationale and Safety Report

  • J. Ragaz
  • R. Baird
  • R. Rebbeck
  • A. Goldie
  • A. Coldman
  • J. Spinelli
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 98)

Abstract

The results of postoperative adjuvant chemotherapy for patients with high-risk carcinoma of the breast (Jones et al. 1981; Bonadonna et al. 1978) suggest an increase in disease-free survival compared with untreated controls. These results are by no means optimum. In the absence of new and more effective single chemotherapy agents for breast cancer, maximum effort should be made to explore the pharmacodynamics and scheduling of the standard chemotherapy regimens. Following this line of approach, we have started a programme that has led us in the past 2 years into the introduction of the study of preoperative adjuvant chemotherapy for breast cancer (Ragaz et al. 1981, 1982).

Keywords

Fatigue Toxicity Europe Syringe Oncol 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • J. Ragaz
    • 1
  • R. Baird
    • 1
  • R. Rebbeck
    • 1
  • A. Goldie
    • 1
  • A. Coldman
    • 1
  • J. Spinelli
    • 1
  1. 1.Cancer Control Agency of British ColumbiaVancouverCanada

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