Rationale for Perioperative Anticancer Treatment

  • F. M. SchabelJr.
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 98)


I will limit my discussion essentially to chemotherapy as an adjuvant to surgery, since my experience is in this field, but I recognize that radiation therapy could be substituted for surgery in many cases and also that there are clinical examples of all three modalities being used in proper sequences with improved results over any two-modality treatment. I would like to begin with a brief discussion of the need for perioperative chemotherapy.


Adjuvant Chemotherapy Body Burden Lewis Lung Carcinoma Tumor Stem Cell Systemic Cancer 
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  1. Corbett TH, Griswold DP Jr, Roberts BT, Peckham JC, Schabel FM Jr (1975) Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure. Cancer Res 35:2434–2439PubMedGoogle Scholar
  2. DeVita VT Jr, Henney JE, Stonehill E (1979) Cancer mortality: the good news. In: Jones SE, Salmon SE (eds) Adjuvant therapy of cancer II. Grune and Stratton, New York, pp XV-XXGoogle Scholar
  3. Moertel CG (1975) Clinical management of advanced gastrointestinal cancer. Cancer 36:675–682PubMedCrossRefGoogle Scholar
  4. Schabel FM Jr (1975) Concepts for systemic treatment of micrometastases. Cancer 35:15–24PubMedCrossRefGoogle Scholar
  5. Schabel FM Jr (1976) Concepts for treatment of micrometastases developed in murine systems. AJ1 126:500–511Google Scholar
  6. Schabel FM Jr, Simpson-Herren L (to be published) Tumor growth kinetics and drug treatment of cancer. In: Kuemmerle HP, Karrer K, Mathé G, Periti P (eds) Clinical chemotherapy, vol 3. Anticancer chemotherapy. Thieme, StuttgartGoogle Scholar
  7. Silverberg E (1981) Cancer statistics 1981. CA 31:13–28PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • F. M. SchabelJr.
    • 1
  1. 1.Southern Research InstituteBirminghamUSA

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