Complement pp 101-114 | Cite as

The Human C3b Receptor

  • Douglas T. Fearon


Many of the biologic effects of the complement system are mediated by cellular receptors that specifically bind certain cleavage peptides and larger fragments of complement proteins that are generated during activation of the system. As is discussed elsewhere in this volume and in a recent review [15], there may be as many as eight different complement receptors on the various cell types that participate in immune and inflammatory reactions. A comprehensive understanding of the mechanisms by which the binding of ligands to these receptors evokes cellular responses requires that the membrane proteins serving as receptors be identified,. isolated, and characterized. Recent studies of the first complement receptor to be purified, the human C3b receptor, which is also termed CR1, is the subject of this review.


Systemic Lupus Erythematosus Systemic Lupus Erythematosus Patient Complement Receptor Sheep Erythrocyte Structural Polymorphism 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Douglas T. Fearon
    • 1
  1. 1.Department of Medicine, Harvard Medical School, and Department of Rheumatology and ImmunologyBrigham and Women’s HospitalBostonUSA

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