Involvement of Pituitary Endorphins in Pain Perception and Their Importance in Pituitary-Stimulation-Induced Analgesia in Animals and Man
In animals severe stress induces analgesia concomittant with a simultaneous increase in the hormonal activity of the pituitary gland (Guillemin et al. 1977; Lewis et al. 1980; Wilier and Albe-Fessard 1980; Rossier et al. 1977).
After surgical hypophysectomy stress-induced analgesia is absent (Vidal et al. 1982; Amir and Amit 1979; Bodnar et al. 1979).
After injection of the opiate (endorphin) antagonist naloxone, stress-induced analgesia is absent (Chesher and Chan 1977; Bodnar et al. 1978).
Other investigators have found high levels of endorphins in the neurohypophysis, with endorphin receptors present and even enkephalinergic neurons in the pituitary region (PR) (Goldstein 1976; Bloom et al. 1978; Simantov and Snijder 1977; Rossier et al. 1980).
KeywordsPituitary Gland Pain Perception Primary Somatosensory Cortex Tooth Pulp Alcohol Injection
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