Involvement of Pituitary Endorphins in Pain Perception and Their Importance in Pituitary-Stimulation-Induced Analgesia in Animals and Man

  • A. Trouwborst
  • H. Yanagida
  • W. Erdmann


Recently, we suggested that the pituitary gland possibly plays a major role in pain perception. Experimental findings by various investigators have supported this idea:
  1. 1.

    In animals severe stress induces analgesia concomittant with a simultaneous increase in the hormonal activity of the pituitary gland (Guillemin et al. 1977; Lewis et al. 1980; Wilier and Albe-Fessard 1980; Rossier et al. 1977).

  2. 2.

    After surgical hypophysectomy stress-induced analgesia is absent (Vidal et al. 1982; Amir and Amit 1979; Bodnar et al. 1979).

  3. 3.

    After injection of the opiate (endorphin) antagonist naloxone, stress-induced analgesia is absent (Chesher and Chan 1977; Bodnar et al. 1978).

  4. 4.

    Other investigators have found high levels of endorphins in the neurohypophysis, with endorphin receptors present and even enkephalinergic neurons in the pituitary region (PR) (Goldstein 1976; Bloom et al. 1978; Simantov and Snijder 1977; Rossier et al. 1980).



Pituitary Gland Pain Perception Primary Somatosensory Cortex Tooth Pulp Alcohol Injection 
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Copyright information

© Springer-Verlag Berlin, Heidelberg 1985

Authors and Affiliations

  • A. Trouwborst
  • H. Yanagida
  • W. Erdmann

There are no affiliations available

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