Abstract
Various prediction test systems for human tumors have been developed during the past decades (Dendy 1976; Kaufmann 1980, 1983; Possinger and Ehrhardt 1983; Kaufmann and Kubli 1983; Salmon 1980; Volm and Mattem 1982). In cancer chemotherapy the availability of an assay which makes an appropriate selection of treatment for the individual patient feasible has long been dreamed of. General informations on an in vitro short-term predictive assay (STPA) will be presented. Besides these basic data, results of correlative trials of this assay are compared to results of other assays involving human tumors.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abel U, Kaufmann M (1982) A methodologically improved definition of chemosensitivity indices. Cancer Res 42: 1610
Alberts DS, Surwit EA, Leigh S, Moon TE, Salmon SE (1982) Improved survival for relapsing ovarian cancer patients using the human tumor stem cell assay to select chemotherapy. Third conference on human tumor cloning, Tucson
Bernheim J, Naaktgeboren N, Roobol C, Thennissen J, Sips H (1982) Efficiency of oncograms by the human tumor stem cell clonogenic assay. Experience after 56 assays. Third conference on human tumor cloning, Tucson
Bertelsen CA, Korn EL, Kern DH (1983) Clinical correlations of the clonogenic assay (CA) with human solid tumors. ASCO Abstract C-26
Bogden AE, Cobb WR, Lepage DJ, Haskell PM, Gulkin TA, Ward A, Kelton DE, Esber HG (1981) Chemotherapy responsiveness of human tumors as first transplant generation xenografts in the normal mouse. Cancer 48: 10
Bogden AE, von Hoff DD, Schwartz JH (1983) Comparison of the human tumor cloning (ATC) and subrenal capsule (SRC) assays. ASCO Abstract C-11
Carney DN, Gazdar AF, Minna JD (1982) In vitro chemosensitivity of clinical specimens and established cell lines of small cell lung cancer. Third conference on human tumor cloning, Tucson
Daidone MG, Silvestrini R, Zaffaroni N, Sanfilippo O, Varini M (1983) Reliability of a short-term antimetabolic assay in predicting drug sensitivity of breast cancer. In: (eds) Endocrine-related tumors. In press
Dendy PP (1976) Human tumors in short-term cultures. Academic Press, New York
Griffin TW, Bogden AE, Reich SD, Hunter RE, Greene HL, Antonelli DM, Constanza ME (1982) Clinical update on the subrenal capsule assay as a predictive test for response to chemotherapy. ASCO Abstract C-67
Group for sensitivity testing of tumors (KSST) (1981) In vitro short-term test to determine the resistance of human tumors to chemotherapy. Cancer 48: 2127
Hogan WM, Ozols RF, Willson JKV, Foster BJ, Grotzinger KJ, McKoy W, Young RC (1982) Application of the human tumor stem cell assay to the study of epithelial ovarian cancer. 13th Annual Meeting of the Society of Gynecologic Oncologists, Marco Island
Kaufmann M (1980) Clinical applications of in vitro chemosensitivity testing. In: Newman CE, Ford CHJ, Jordan JA (eds) Ovarian cancer. Advances in the biosciences, vol 26. Pergamon, Oxford, p 189
Kaufmann M (1982) Nucleic acid precursor incorporation assay for testing tumour sensitivity and clinical application. Drugs. Exp Clin Res 8: 345
Kaufmann M (1983) Clinical aspects of chemosensitivity testing modalities in ovarian cancer. In: Grundmann E (ed) Cancer campain, vol 7. Carcinoma of the ovary. Fischer, Stuttgart
Kaufmann M, Kubli F (1983) Gegenwärtiger Stand der Chemosensibilitätstestung von Tumoren. Dtsch Med Wochenschr 108: 150–154
Mann BD, Kern DH, Giuliano AE, Burk MW, Campbell MA, Kaiser LR, Morton DL (1982) Clinical correlations with drug sensitivities in the clonogenic assay. Arch Surg 117: 33
Natale RB, Kushner B (1981) Applications of the human tumor cloning assay to ovarian cancer. AACR Abstract 617
Parker RL, Welander CE, Homesley HD, Jabson VW (1983) Chemotherapy sensitivity of carcinomas of the cervix (CACX) determined by the human tumor stem cell assay (HTSCA). ASCO Abstract C-87
Pfleiderer A (1980) Is chemosensitivity testing worth-while? Report of a cooperative study. Excerpta Medica, Amsterdam, International Congress Series, p 1143
Pfleiderer A (1982) Six years of experience with Volm’s chemosensitivity testing of ovarian cancer. EORTC symposium on ovarian cancer, Stockholm
Possinger K, Ehrhardt H (1983) Prädiktive Tumorteste im chemotherapeutischen Behandlungskonzept maligner Erkrankungen. Klin Wochenschr 61: 77–84
Possinger K, Hartenstein R, Ehrhart H, Wilmanns W (1982) In-vitro-Erkennung von Tumorzell resistenz gegen antiproliferative Substanzen. Deutscher Krebskongreß, München
Salmon SE (ed) (1980) Cloning of human tumor stem cells. Prog Clin Biol Res 48
Salmon SE, von Hoff DD (1981) In vitro evaluation of anticancer drugs with the human tumor stem cell assay. Semin Oncol 8: 377
Sanfilippo O, Daidone MG, Costa A, Canetta R, Silvestrini R (1981) Estimation of differential in vitro sensitivity of non-Hodgkin lymphomas to anticancer drugs. Eur J Cancer 17: 217–226
Sanfilippo O, Silvestrini RS, Zaffaroni N, Piva L (1983) Potentiality of an in vitro chemosensitivity assay for human germ cell testicular tumors (GCTT). ASCO Abstract C-145
Silvestrini R (1981) Experimental approaches to improve the clinical management of tumors. Chemother Oncol 5: 14
Stratton JA, Micha JP, Braly PS, Rettenmaier MA, DiSaia PJ (1983) Correlation between chemotherapeutic sensitivity measured by the subrenal capsule tumor implant assay and the clinical response of patients with gynecologic tumors. ASCO Abstract C-125
Volm M, Mattem J (1982) Prätherapeutischer Nachweis der Resistenz von Tumoren gegen Zytostatika. Wien Klin Wochenschr 94: 599–604
Volm M, Wayss K, Kaufmann M, Mattem J (1979) Pretherapeutic detection of tumour resistance and the results of tumour chemotherapy. Eur J Cancer 15: 983
von Hoff DD, Casper J, Bradley E, Sandbach J, Jones D, Makuch R (1981) Asociation between human tumor colony-forming assay results and response of an individual patient’s tumor to chemotherapy. Am J Med 70: 1027
von Hoff DD, Clark GM, Stogdill BJ, Sarosdy MF, O’Brien MT, Casper TJ, Mattox DE, Page CP, Cruz AB, Sandbach JF (1983) Prospective clinical trial of a human tumor cloning system. Cancer Res 43: 1926–1931
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Kaufmann, M. (1984). Biochemical Short-Term Predictive Assay: Results of Correlative Trials in Comparison to Other Assays. In: Hofmann, V., Berens, M.E., Martz, G. (eds) Predictive Drug Testing on Human Tumor Cells. Recent Results in Cancer Research, vol 94. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82295-7_15
Download citation
DOI: https://doi.org/10.1007/978-3-642-82295-7_15
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-82297-1
Online ISBN: 978-3-642-82295-7
eBook Packages: Springer Book Archive