Zusammenfassung
Eine umfassende Beurteilung der Strahlenempfindlichkeit des Knochenmarks und der klinischen Konsequenzen, die sich nach verschiedenen Formen einer Strahleneinwirkung aus der Störung der Blutzellbildung ergeben, muß von Kenntnissen der Struktur und Funktion dieses komplexen Organs ausgehen. Deshalb soll diesem Kapitel eine kurze Beschreibung der Biologie des Knochenmarks vorangestellt werden.
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Literatur
Ainsworth EJ, Fry RJM, Williamson FS, Kisielski WE, Jordan DL, O’Malley MP, Miller M, Cooke EM, Sallese A, Brennan PC (1971) Relative biological effectiveness of neutrons from the Janus reactor. Argonne National Laboratory Report ANL-7870, pp 19–26
Ainsworth EJ, Fry RJM, Grahn D, Williamson FS, Rust JH, Brennan PC, Carrano AV, Jordan DL, Miller M, Allen KH, Nielsen MP, Cooke E, Staffeldt E, Sallese A (1972) Progress of JM-2 and related neutron- and gamma-radiation toxicity studies. Argonne National Laboratory Report ANL-7970, pp 13–29
Ainsworth EJ, Fry RJM, Jordan DL, Sallese AR (1973) Radiation sensitivity and recovery: strain differences, age sensitivity, and split-dose recovery studies. Argonne National Laboratory Report ANL-8070, pp 10–12
Ainsworth EJ, Jordan DL, Miller M, Cooke EM, Hulesch JS (1976) Dose rate studies with fission spectrum neutrons. Radiat Res 67:30–45
Alpen EL, Shill OS, Tochilin E (1960) The effects of total-body irradiation of dogs with simulated fission neutrons. Radiat Res 12:237–250
Barendsen GW (1981) The influence of dose fractionation and dose rate on normal tissue responses. Annual Report 1981, Radiobiological Institute TNO, Institute for Experimental Gerontology TNO, Primate Center TNO, Rijswijk, pp 13–16
Bateman JL, Bond VP, Robertson JS (1962) Dose-rate dependence of early radiation effects in small mammals. Radiology 79:1008–1014
Baumann B, Muth H (1977) Zur Frage der Erholungsfähigkeit von Säugetieren nach akuter subletaler Ganzkörperbestrahlung mit energiereichen Strahlen unter Berücksichtigung des jugendlichen Organismus. In: Messerschmidt O, Möhrle G, Zimmer R, Holeczke F, Kainberger F, Kärcher KH, Mader H, Seyss R (Hrsg) Vorsorgemedizin und Strahlenschutz (Risiko/Nutzen-Analyse). Erholungsvorgänge nach Strahleneinwirkung. Medizinische Aspekte der Strahlenschutzgesetzgebung in verschiedenen europäischen Ländern. Thieme, Stuttgart (Strahlenschutz in Forschung und Praxis, Bd XVIII, S 35–45)
Becker AJ, McCulloch EA, Till JE (1963) Cytological demonstration of the clonal nature of spleen colonies derived from transplanted bone marrow cells. Nature 197:452–454
Becker AJ, McCulloch EA, Siminovitch L, Till JE (1965) The effects of differing demands for blood cell production on DNA synthesis by hemopoietic colony-forming cells of mice. Blood 26: 296–308
Blackett NM, Roylance PJ, Adams K (1964) Studies on the capacity of bone-marrow cells to restore erythropoiesis in heavily irradiated rats. Br J Haematol 10:453–467
Boggs SS, Boggs DR (1975) Earlier onset of hematopoietic differentiation after expansion of the endogenous stem cell pool. Radiat Res 63:165–173
Boll I (1978) Das granulozytäre Zellsystem. In: Queisser W (Hrsg) Das Knochenmark — Morphologie Funktion Diagnostik. Thieme, Stuttgart, S 167–192
Bond VP (1964) Comparison of the mortality response of different mammalian species to X-rays and fast neutrons. In: International Atomic Energy Agency (ed) Biological effects of neutron and proton irradiations, vol II. IAEA, Vienna, pp 365–377
Bond VP (1969) Radiation mortality in different mammalian species. In: Bond VP, Sugahara T (eds) Comparative cellular and species radio-sensitivity. Igaku Shoin, Tokyo, pp 5–19
Bond VP, Robinson CV (1967) A mortality determinant in nonuniform exposures of the mammal. Radiat Res [Suppl] 7:265–275
Bond VP, Swift MN, Allen AC, Fishier MC (1950) Sensitivity of abdomen of rat to X-irradiation. Am J Physiol 161: 323–330
Bond VP, Carter RE, Robertson JS, Seymour PH, Hechter HH (1956) The effects of total-body fast neutron irradiation in dogs. Radiat Res 4:139–153
Bond VP, Fliedner TM, Archambeau JO (1965) Mammalian radiation lethality. A disturbance in cellular kinetics. Academic Press, New York London
Briganti G, Mauro F (1979) Differences in radiation sensitivity in subpopulations of mammalian multicellular systems. Int J Radiat Oncol Biol Phys 5:1095–1101
Broerse JJ (1969) Dose-mortality studies for mice irradiated with X-rays, gamma-rays and 15 MeV neutrons. Int J Radiat Biol 15:115–124
Broerse JJ, Barendsen GW (1973) Relative biological effectiveness of fast neutrons for effects on normal tissues. Curr Top Radiat Res Quarterly 8: 305–350
Broerse JJ, Engels AC, Lelieveld P, Putten LM van, Duncan W, Greene D, Massey JB, Gilbert CW, Hendry JH, Howard A (1971) The survival of colony-forming units in mouse bone marrow after in vivo irradiation with D-T neutrons, X- and gamma-radiation. Int J Radiat Biol 19:101–110
Broerse JJ, Bekkum DW van, Hollander CF, Davids JAG (1978) Mortality of monkeys after exposure to fission neutrons and the effect of autologous bone marrow transplantation. Int J Radiat Biol 34:253–264
Caffrey RW, Everett NB, Rieke WO (1966) Radioautographic studies of reticular and blast cells in the hemopoietic tissues of the rat. Anat Rec 55:41–58
Carsten AL, Noonan TR (1964)- Hematological effects of partial-body and whole-body X-irradiation in the rat. Radiat Res 22:136–143
Carter RE, Bond VP, Seymour PH (1956) The relative biological effectiveness of fast neutrons in mice. Radiat Res 4:413–423
Casarett GW (1969) Patterns of recovery from large single-dose exposure to radiation. In: Bond VP, Sugahara T (eds) Comparative cellular and species radiosensitivity. Igaku Shoin, Tokyo, pp 42–52
Chadwick KH, Leenhouts HP (1973) A molecular theory of cell survival. Phys Med Biol 18:78–87
Chervenick PA, Boggs DR (1971) Patterns of proliferation and differentiation of hematopoietic stem cells after compartment depletion. Blood 37:568–580
Cline MJ, Golde DW (1979) Controlling the production of blood cells. Blood 53:157–165
Coggle JE (1980) Absence of late radiation effects on bone marrow stem cells. Int J Radiat Biol 38:589–595
Coggle JE, Gordon MY (1975) Quantitative measurements on the haemopoietic systems of three strains of mice. Exp Hematol 3:181–186
Cole LJ, Haire HM, Alpen EL (1967) Partial shielding of dogs: effectiveness of small external epicondylar lead cuffs against lethal X-irradiation. Radiat Res 32: 54–63
Croizat H, Frindel E, Tubiana M (1979) Long-term radiation effects on the bone marrow stem cells of C3H mice. Int J Radiat Biol 36:91–99
Croizat H, Frindel E, Tubiana M (1980) The effect of partial body irradiation on haemopoietic stem cell migration. Cell Tissue Kinet 13:319–325
Cronkite EP, Bond VP (1960) Diagnosis of radiation injury and analysis of the human lethal dose of radiation. US Armed Forces Med J 11:249–260
Cronkite EP, Fliedner TM (1972) The radiation syndromes. In: Hug O, Zuppinger A (Hrsg) Strahlenbiologie 3. Handbuch der medizinischen Radiolo- gie, Bd II/3. Springer, Berlin Heidelberg New York, S 299–339
Crosfill ML, Lindop PJ, Rotblat J (1959) Variation of sensitivity to ionizing radiation with age. Nature 183:1729–1730
Davids JAG (1970) Bone marrow syndrome in CBA mice exposed to fast neutrons of 1.0 MeV mean energy. Effect of syngeneic bone marrow transplantation. Int J Radiat Biol 17:173–185
Davids JAG (1973) Acute effects of 1-MeV fast neutrons on the haematopoietic tissues, intestinal epithelium and gastric epithelium in mice. In: Du-plan JF, Chapiro A (eds) Advances in radiation research, vol 2. Gordon and Breach Science Publishers, New York London Paris, pp 565–576
DeGowin RL, Chaudhuri TK, Cristie JH, Callis MN, Mueller AL (1974) Marrow scanning in evaluation of hemopoiesis after radiotherapy. Arch Intern Med 134:297–303
Dexter TM, Spooncer E, Hendry J, Lajtha LG (1978) Stem cells in vitro. In: Golde DW, Cline MJ, Metcalf D, Fox CF (eds) Hematopoietic cell differentiation. ICN-UCLA Symposia on Molecular and Cellular Biology, vol X. Academic Press, New York San Francisco London, pp 163–173
Dörmer P (1978) Das erythrozytäre Zellsystem. In: Queisser W (Hrsg) Das Knochenmark — Morphologie Funktion Diagnostik. Thieme, Stuttgart, S 150–166
Drasil V, Juraskova V, Koukalova B (1975) The influence of continuous irradiation on the colony forming activity of mouse bone-marrow. Int J Radiat Biol 11: 613–614
Eltringham JR (1967) Recovery of the rhesus monkey from an acute radiation exposure as evaluated by the split-dose technique: Preliminary results. Radiat Res 31:533 (Abstract)
Faille A, Maraninchi D, Gluckman E, Devergie A, Balitrand N, Ketels F, Dresch C (1981) Granulocyte progenitor compartments after allogeneic bone marrow grafts. Scand J Haematol 26:202–214
Fauser AA, Messner HA (1978) Granuloerythropoietic colonies in human bone marrow, peripheral blood, and cord blood. Blood 52:1243–1248
Fauser AA, Messner HA (1979) Proliferative state of human pluripotent hemopoietic progenitors (CFU-GEMM) in normal individuals and under regenerative conditions after bone marrow transplantation. Blood 54:1197–1200
Fliedner TM (1973) Pathophysiologie der Strahlenempfindlichkeit des Knochenmarks. In: Braun H, Heuck F, Ladner HA, Messerschmidt O, Musshof K, Streffer C (Hrsg) Strahlenempfindlichkeit von Organen und Organsystemen der Säugetiere und des Menschen. Strahlenschutz in Forschung und Praxis, Bd XIII. Thieme, Stuttgart, S 28–48
Fliedner TM (1974) Kinetik und Regulationsmechanismen des Granulozytenumsatzes. Schweiz Med Wochenschr 104:98–107
Fliedner TM, Calvo W (1978) Hematopoietic stem-cell seeding of a cellular matrix: a principle of initiation and regeneration of hematopoiesis. In: Cold Spring Harbor Conferences on Cell Proliferation, vol 5. Clarkson B, Marks PA, Till JE (eds) Differentiation of normal and neoplastic hematopoietic cells, book B. Cold Spring Harbor Laboratory, pp 757–773
Fliedner TM, Flad HD, Bruch C, Calvo W, Goldmann S, Herbst E, Hügl E, Huget R, Körbling M, Krumbacher K, Nothdurft W, Ross WM, Schnappauf HP, Steinbach I (1976) Treatment of aplastic anemia by blood stem cell transfusion: a canine model. Haematologica 61:141–156
Fliedner TM, Steinbach KH, Raffler H (1977) Erholungsvorgänge im Stammzellenbereich des Knochenmarkes nach Strahleneinwirkung. In: Messerschmidt O, Möhrle G, Zimmer R, Holeczke F, Kainberger F, Kärcher KH, Mader H, Seyss R (Hrsg) Vorsorgemedizin und Strahlenschutz (Risiko/Nutzen-Analyse). Erholungsvorgänge nach Strahleneinwirkung. Medizinische Aspekte der Strahlenschutzgesetzgebung in verschiedenen europäischen Ländern. Strahlenschutz in Forschung und Praxis, Bd XVIII. Thieme, Stuttgart, S 4–20
Fliedner TM, Hoelzer D, Steinbach KH (1978) Physiologische und pathologische Regulation der Erythropoese. Verh Dtsch Ges Inn Med 84:15–27
Fritz TE, Norris WP, Tolle DV, Seed TM, Poole CM, Lombard LS, Doyle DE (1978) Relationship of dose rate and total dose to responses of continuously irradiated beagles. In: International Atomic Energy Agency (ed) Late biological effects of ionizing radiation, vol II. IAEA, Vienna, pp 71–82
Garner RJ, Phemister RD, Angleton GM, Lee AC, Thomassen RW (1974) Effect of age on the acute lethal response of the beagle to Cobalt-60 gamma radiation. Radiat Res 58:190–195
Gerber GB, Maes J (1980) Stem cell kinetics in spleen and bone marrow after single and fractionated irradiation of infant mice. Radiat Environ Biophys 18: 249–256
Gidali J (1975) Response of stem cell system to whole body and partial body irradiation. In: Nygaard OF, Adler HJ, Sinclair WS (eds) Radiation research. Academic Press, New York San Francisco London, pp 788–796
Gidali J, Feher I, Antal S (1974) Some properties of circulating hemopoietic stem cells. Blood 43:573–580
Gidali J, Bojtor I, Feher I (1979) Kinetic basis for compensated hemopoiesis during continuous irradiation with low doses. Radiat Res 77:285–291
Goldman JM (1980) Haemopoietic stem cell auto-grafts for leukaemia. Blut 41:71–79
Goswitz FA, Andrews GA, Kniseley RM (1963) Effects of local irradiation (Co60 teletherapy) on the peripheral blood and bone marrow. Blood 21:605–619
Guzman E, Lajtha LG (1970) Some comparisons of the kinetic properties of femoral and splenic haemopoietic stem cells. Cell Tissue Kinet 3:91–98
Haas RJ (1971) Die Rolle zytokinetisch ruhender Zellen für die Regeneration eines aplastischen Knochenmarkes. Autoradiographische Untersuchungen an der Ratte. Aerztl Forsch 25:185–194
Haas RJ, Bohne F, Fliedner TM (1971) Cytokinetic analysis of slowly proliferating bone marrow cells during recovery from radiation injury. Cell Tissue Kinet 4:31–45
Hendry JH (1972) The response of haemopoietic colony-forming units and lymphoma cells irradiated in soft tissue (spleen) or a bone cavity (femur) with single doses of X rays, y rays or D-T neutrons. Br J Radiol 45:923–932
Hendry JH (1973) Differential split-dose radiation response of resting and regenerating haemopoietic stem cells. Int J Radiat Biol 24:469–473
Hendry JH (1979) The dose-dependence of the split-dose response of marrow colony-forming units (CFU-S): similarities to other tissues. Int J Radiat Biol 36: 631–636
Hendry JH, Howard A (1971) The response of haemopoietic colony-forming units to single and split doses of y-rays or D-T neutrons. Int J Radiat Biol 19:51–64
Hendry JH, Lajtha LG (1972) The response of hemopoietic colony-forming units to repeated doses of X-rays. Radiat Res 52:309–315
Hendry JH, Lajtha LG (1975) Response of mouse bone marrow to low dose rates, split acute doses, and multiple daily fractions. In: Alper T (ed) Cell survival after low doses of radiation: Theoretical and clinical implications. The Institute of Physics, Wiley, Bristol, pp 308–312
Hendry JH, Potten CS (1974) Cryptogenic cells and proliferative cells in intestinal epithelium. Int J Radiat Biol 25: 583–588
Hendry JH, Testa NG, Lajtha LG (1974) Effect of repeated doses of X-rays or 14 MeV neutrons on mouse bone marrow. Radiat Res 59:645–652
Heyden HW von (1978) Die ortsständigen Knochenmarkzellen. In: Queisser W (Hrsg) Das Knochenmark — Morphologie Funktion Diagnostik. Thieme, Stuttgart, S 99–107
Hill DR, Benak SB, Phillips TL, Price DC (1980) Bone marrow regeneration following fractionated radiation therapy. Int J Rad Oncol Biol Phys 6:1149–1155
Hornsey S (1967) The recovery process in organized tissue. In: Silini G (ed) Radiation research. North-Holland Publishing, Amsterdam, pp 587–603
Hornsey S, Vatistas S, Bewley DK, Parnell CJ (1965) The effect of fractionation on four day survival of mice after whole-body neutron irradiation. Br J Radiol 38:878–880
Hübner GE, Wangenheim K-H von, Feinendegen LE (1981) An assay for the measurement of residual damage of murine hematopoietic stem cells. Exp Hematol 9:111–117
IAEA Safety Series No 47 (1978) Manual on Early Medical Treatment of Possible Radiation Injury. With an appendix on sodium burns. International Atomic Energy Agency, Vienna
International Commission on Radiological Protection No 23 (1974) Report of the task group on reference man. Pergamon Press, Oxford New York Toronto Sydney Braunschweig, pp 85–98
Iscove NN (1978) Regulation of proliferation and maturation at early and late stages of erythroid differentiation. In: Saunders GF (ed) Cell differentiation and neoplasia. Raven Press, New York, pp 195–209
Jablon S, Fujita S, Fukushima K, Ishimaru T, Auxier JA (1969) RBE of neutrons in Japanese survivors. In: Symposium on Neutrons in Radiobiology. US Atomic Energy Commission Rep Conf 691106, pp 547–579
Jacobson LO, Simmons EL, Bethard WF, Marks EK, Robson MJ (1950) The influence of the spleen on hematopoietic recovery after irradiation injury. Proc Soc Exp Biol Med 73:455–459
Kallman RF, Silini G (1964) Recuperation from lethal injury by whole-body irradiation. I Kinetic aspects and the relationship with conditioning dose in C57B1 mice. Radiat Res 22:622–642
Kaplan HS, Brown MB (1952) Mortality of mice after total-body irradiation as influenced by alteration in total dose, fractionation, and periodicity of treatment. J Natl Cancer Inst 12: 756–775
Keyserlingk DG von (1978) Anatomie des Knochenmarks. In: Queisser W (Hrsg) Das Knochenmark - Morphologie Funktion Diagnostik. Thieme, Stuttgart, S 78–95
Kindt A, Sattler EL (1977) Literaturübersicht zur Frage der Erholung nach Ganzkörperbestrahlung. Bundesamt für Zivilschutz (Hrsg) Zivilschutzforschung, Bd 6. Osang, Bad Honnef-Erpel
Knospe WH, Blom J, Crosby WH (1966) Regeneration of locally irradiated bone marrow. I Dose dependent, long-term changes in the rat, with particular emphasis upon vascular and stromal reaction. Blood 28:398–415
Knospe WH, Rayudu VM, Cardello M, Friedman AM, Fordham EW (1976) Bone marrow scanning with 52iron (52Fe). Regeneration and extension of marrow after ablative dose of radiotherapy. Cancer 37:1432–1442
Körbling, M, Burke P, Braine H, Elfenbein G, Santos G, Kaizer H (1981) Successful engraftment of blood derived normal hemopoietic stem cells in chronic myelogenous leukemia. Exp Hematol 9:684–690
Krebs JS, Brauer RW (1952) Residual injury caused by irradiation with fast neutrons. Radiat Res 11:855–863
Krebs JS, Brauer RW (1964) Comparative accumulation of injury from X-, gamma and neutron irradiation — the position of theory and experiment. In: International Atomic Energy Agency (ed) Biological effects of neutron and proton irradiation, vol II. IAEA, Vienna, pp 347–364
Krokowski E, Taenzer V (1966) Der radiogene Strah- lenschutzeffekt. Strahlentherapie 130:139–145
Lajtha LG (1979) Stem cell concepts. Differentiation 14:23–34
Lajtha LG, Pozzi LV, Schofield R, Fox M (1969) Kinetic properties of hemopoietic stem cells. Cell Tissue Kinet 2:39–49
Lahiri SK (1976) Kinetics of haemopoietic recovery in endotoxin-treated mice. Cell Tissue Kinet 9:31–39
Lamerton LF (1966) Cell proliferation under continuous irradiation. Radiat Res 27:119–138
Lamerton LF (1968) Radiation biology and cell population kinetics (The Tenth Douglas Lea Memorial Lecture). Phys Med Biol 13:1–14
Lamerton LF, Pontifex AH, Blackett NM, Adams K (1960) Effects of protracted irradiation on the blood-forming organs of the rat. Part I Continuous Exposure. Br J Radiol 33:287–301
Langendorff H, Langendorff M, Metzner R, Mönig H, Steinbach K-H, Tumbrägel G (1970) Radio-biological investigations with fast neutrons. I Comparative investigations on the mortality of male mice after an irradiation with 15 MeV-neutrons and 60Co-y-rays. Atomkernenergie 16:255–260
Langendorff H, Langendorff M, Mönig H (1973) Die Änderung der Strahlenempfindlichkeit der Maus nach Vorbestrahlung mit schnellen Neutronen oder Röntgenstrahlen. Strahlentherapie 146: 327–338
Langham WH (ed) (1967) Radiobiological factors in manned space flight. National Academy of Sciences, National Research Council, Washington DC
Lichtman MA (1981) The ultrastructure of the hemopoietic environment of the marrow: a review. Exp Hematol 9: 391–410
Loewe WE, Mendelsohn E (1981) Revised dose estimates at Hiroshima and Nagasaki. Health Phys 41:663–666
Lord BI (1975) Cell proliferation changes in hemopoietic tissue as a result of irradiation or drug administration: the control of cell proliferation in hemopoietic tissue. In: Nygaard OF, Adler HI, Sinclair WK (eds) Radiation research. Academic Press, New York San Francisco London, pp 826–833
Lushbaugh CC (1969) Reflections on some recent progress in human radiobiology. In: Augenstein LC, Mason R, Zelle M (eds) Advances in radiation biology, vol 3. Academic Press, New York London, pp 277–314
Lushbaugh CC (1974) Human radiation tolerance. In: Tobias CA, Todd P (eds) Space radiation bi- ology and related topics. Academic Press, New York London, pp 475–522
Maloney MA, Patt HM (1972 a) Migration of cells from shielded to irradiated marrow. Blood 39:804–808
Maloney MA, Patt HM (1972b) Persistent marrow hypocellularity after local irradiation of the rabbit femur with 1000 rad. Radiat Res 50:284–292
Maloney MA, Patt HM (1978) Marrow stem cell release in the autorepopulation assay. Exp Hematol 6:227–232
Martinez RG, Cassab GH, Ganem GG, Guttman KE, Lieberman ML, Vater LB, Linares MM, Rodriguez HM (1964) Accident from radiation: observations on the accidental exposure of a family to a source of Cobalt-60. Rev Med Inst Mex Seguro Soc 3 [Suppl] 1:14–69 (English translation by Comas FV)
McCulloch EA, Till JE (1962) The sensitivity of cells from normal mouse bone marrow to gamma radiation in vitro and in vivo. Radiat Res 16:822–832
Metcalf D (1972) Effect of thymidine suiciding on colony formation in vitro by mouse hematopoietic cells. Proc Soc Exp Biol Med 139:511–514
Metcalf D, Moore MAS (1971) Haemopoietic Cells. North-Holland Publishing, Amsterdam London
Micklem HS, Anderson N, Ross E (1975) Limited potential of circulating haemopoietic stem cells. Nature 256:41–43
Mizoguchi H, Kubota K, Miura Y, Takaku F (1979) An improved plasma culture system for the production of megakaryocyte colonies in vitro. Exp Hematol 7: 345–351
Mole RH (1957) Quantitative observations on recovery from whole body irradiation in mice. II Recovery during and after daily irradiation. Br J Radiol 30:40–46
Mole RH (1975) Deductions about survival curve parameters from iso-effect radiation regimes: observations on lethality after whole-body irradiation of mice. In: Alper T (ed) Cell survival after low doses of radiation. The Institute of Physics. Wiley, Bristol, pp 299–303
Mönig H (1978) Biologische Wirkungen von Neutronen bei Säugetieren und beim Menschen. In: Bundesamt für Zivilschutz (Hrsg) Zivilschutzforschung, Bd 8. Osang, Bad Honnef-Erpel, S 39–65
Nachtwey DS, Ainsworth EJ, Leong GF (1967) Recovery from irradiation injury in swine as evaluated by the split-dose technique. Radiat Res 31:353–367
Nakeff A, McLellan WL, Bryan J, Valeriote FA (1979) Response of megakaryocyte, erythroid, and granulocyte-macrophage progenitor cells in mouse bone marrow to gamma-irradiation and cyclophosphamide. In: Baum J, Ledney GD (eds) Experimental hematology today. Springer, Berlin Heidelberg New York, pp 99–104
NCRP Report No 39 (1974) Basic radiation protection criteria, 2nd reprinting. National Council on Radiation Protection and Measurements, Washington DC 20014
Necas E (1982) Stem cell (CFU-s) proliferation in sublethally irradiated mice. Cell Tissue Kinet 15: 667–672
Neumann HA, Löhr GW, Fauser AA (1981) Radiation sensitivity of pluripotent hemopoietic progenitors (CFUGEMM) derived from human bone marrow. Exp Hematol 9: 742–744
Norris WP, Tyler SA, Sacher GA (1976) An inter-species comparison of responses of mice and dogs to continuous 60Co γ irradiation. In: International Atomic Energy Agency (ed) Biological and environmental effects of low-level radiation, vol I. IAEA, Vienna, pp 147–156
Nothdurft W, Fliedner TM (1979) Stem cell migration after irradiation. In: Okada S, Imamura M, Terasima M, Yamaguchi H (eds) Radiation research. Toppan, Tokyo, pp 657–663
Ohkita T (1975) Acute effects. J Radiat Res [Suppl] 16:49–66
Paterson E, Gilbert CW, Haigh MV (1956) Effects of paired doses of whole-body irradiation in the rhesus monkey. Br J Radiol 29: 218–226
Patt HM (1969) Species differences in leukocyte restoration after irradiation. In: Bond VP, Sugahara T (eds) Comparative cellular and species radiosensitivity. Igaku Shoin, Tokyo, pp 112–122
Patt HM, Maloney MA (1975) Bone marrow regeneration after local injury: a review. Exp Hematol 3:135–148
Patt HM, Quastler H (1963) Radiation effects on cell renewal and related systems. Physiol Rev 43:357–396
Prasad KN (1974) Human radiation biology. Harper and Row, Hagerstown New York Evanston San Francisco London
Proukakis C, Lindop PJ (1967) Age dependence of radiation sensitivity of haemopoietic cells in the mouse. Nature 215:655–656
Proukakis C, Coggle JE, Lindop PJ (1969) Effect of age at exposure on the marrow stem-cell population in relation to 30-day mortality in mice. In: Sikov MR, Mahlum DD (eds) Radiation biology of the fetal and juvenile mammal. US Atomic Energy Commission, Oak Ridge, pp 603–612
Queisser W (1978) Das thrombozytäre Zellsystem. In: Queisser W (Hrsg) Das Knochenmark — Morphologie Funktion Diagnostik. Thieme, Stuttgart, S 209–226
Quesenberry P, Levitt L (1979 a) Hematopoietic stem cells (First of three parts). N Engl J Med 301:755–760
Quesenberry P, Levitt L (1979 b) Hematopoietic stem cells (Second of three parts). N Engl J Med 301:819–823
Reactor Safety Study Wash-1400 (1975) Appendix F. US Nuclear Regulatory Commission Robinson WA, Mangalik A (1975) The kinetics and regulation of granulopoiesis. Semin Hematol 12:7–25
Rubin P, Landman S, Mayer E, Keller B, Ciccio S (1973) Bone marrow regeneration and extension after extended field irradiation in Hodgkin’s disease. Cancer 32:699–711
Schneider DO, Whitmore GF (1963) Comparative effects of neutrons and X-rays on mammalian cells. Radiat Res 18:286–306
Schofield R (1978) The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells 4:7–25
Schofield R, Dexter TM (1982) CFU-S repopulation after low-dose whole-body radiation. Radiat Res 189:607–617
Siminovitch L, McCulloch EA, Till JE (1963) The distribution of colony-forming cells among spleen colonies. J Cell Comp Physiol 62:327–336
Slanina J, Musshoff K, Rahner T, Stiasny R (1977) Long-term side effects in irradiated patients with Hodgkin’s disease. Int J Rad Oncol Biol Phys 2:1–19
Spitzer G, Verma DS, Fisher R, Zander A, Vellekoop L, Litam J, McCredie KB, Dicke KA (1980) The myeloid progenitor cell — its value in predicting hematopoietic recovery after autologous bone marrow transplantation. Blood 55:317–323
Storb R, Graham TC, Epstein RB, Sale GE, Thomas ED (1977) Demonstration of hemopoietic stem cells in the peripheral blood of baboons by cross circulation. Blood 50:537–542
Sullivan MF, Marks S, Hackett PL, Thompson RC (1959) X-irradiation of the exteriorized or in situ intestine of the rat. Radiat Res 11:653–666
Swift MN, Taketa ST, Bond VP (1956) Efficacy of hematopoietic protective procedures in rats X-irradiated with intestine shielded. Radiat Res 4:186–192
Sykes MP, Chu F, Savel H, Bonadonna G, Mathis H (1964) The effects of varying dosages of irradiation upon sternal-marrow regeneration. Radiology 83:1084–1088
Sykes MP, Chu F, Gee TS, McKenzie S (1974) Follow up long-term effects of therapeutic irradiation on bone marrow. Radiology 113:179–180
Testa NG, Hendry JH, Lajtha LG (1973) The response of mouse haemopoietic colony formers to acute or continuous gamma irradiation. Biomedicine 19:183–186
Till JE (1963) Quantitative aspects of radiation lethality at the cellular level. Am J Roentgenol, Rad Therapy and Nuclear Med 90:917–927
Till JE, McCulloch EA (1961) A direct measurement of the radiation sensitivity of normal mouse marrow cells. Radiat Res 14:213–222
Till JE, McCulloch EA (1963) Early repair processes in marrow cells irradiated and proliferating in vivo. Radiat Res 18:96–105
Tolle DV, Seed TM, Fritz TE, Norris WP (1979) Irradiation-induced canine leukemia: A proposed new model: Incidence and Hematopathology. In: Baum SJ, Ledney GD (eds) Experimental hematology today 1979. Springer, Berlin Heidelberg New York, pp 247–256
Trentin JJ (1976) Hemopoietic inductive microenvironments. In: Cairnie AB, Lala PK, Osmond DG (eds) Stem cells of renewing cell populations. Academic Press, New York San Francisco London, pp 255–264
Trott K-R (1972) Strahlenwirkungen auf die Vermehrung von Säugetierzellen. In: Hug O, Zuppinger A (Hrsg) Strahlenbiologie 3. Handbuch der medizinischen Radiologie, Bd I1/3. Springer, Berlin Heidelberg New York, S 43–125
Vogel HH, Clark JW, Jordan DL (1957 a) Comparative mortality following single whole-body exposures of mice to fission neutrons and 60Co gamma rays. Radiology 68:386–398
Vogel HH, Clark JW, Jordan DL (1957 b) Comparative mortality after 24-hour, whole-body, exposures of mice to fission neutrons and Cobalt-60 gamma rays. Radiat Res 6:460–468
Vos O (1972) Stem cell renewal in spleen and bone marrow of mice after repeated total-body irradiations. Int J Radiat Biol 22:41–50
Vries FAJ, Vos O (1966) Preventation of the bone-marrow syndrome in irradiated mice. A comparison of the results after bone-marrow shielding and bone-marrow inoculation. Int J Radiat Biol 11:235–243
Vriesendorp HM, Bekkum DW van (1980) Role of total body irradiation in conditioning for bone marrow transplantation. In: Thierfelder S, Rodt H, Kolb JH (eds) Immunobiology and bone marrow transplantation. Springer, Berlin Heidelberg New York, pp 349–364
Werts ED, Johnson MJ, DeGowin RL (1977) Postirradiation hemopoietic repopulation and stromal cell viability. Radiat Res 71:214–224
Wu AM, Till JE, Siminovitch L, McCulloch EA (1967) A cytological study of the capacity for differentiation of normal haemopoietic colony forming cells. J Cell Physiol 69:177–184
Wu Chu-Tse, Lajtha LG (1975) Haemopoietic stem cell kinetics during continuous irradiation. Int J Radiat Biol 27:41–50
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© 1985 Springer-Verlag Berlin · Heidelberg
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Nothdurft, W. (1985). Knochenmark. In: Heuck, F., Scherer, E. (eds) Strahlengefahrdung und Strahlenschutz / Radiation Exposure and Radiation Protection. Handbuch der Medizinischen Radiologie / Encyclopedia of Medical Radiology, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82229-2_8
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