Zusammenfassung
Die Abdominalorgane sind relativ strahlenempfindlich und haben deshalb seit jeher der Strahlentherapie der Tumoren des Abdominalraums (mit Ausnahme der Tumoren des kleinen Beckens) enge Grenzen gesetzt. Wenn auch die pathogenetischen Mechanismen aller akuten Strahlenfolgen der verschiedenen Organe wie auch aller chronischen Strahlenfolgen jeweils gleich sind [im übrigen ja die gleichen wie an der Haut, wo sie im Detail beschrieben werden (s.S. 176ff.)], sind die klinischen und pathomorphologischen Folgezustände entsprechend der unterschiedlichen Struktur und Funktion der verschiedenen Organe doch so unterschiedlich, daß eine separate Darstellung der Strahlenfolgen von Magen, Darm und Leber angezeigt ist. Angesichts der zum Teil kaum mehr zu übersehenden Fülle von klinischen und experimentellen Arbeiten (insbesondere über die Strahlenreaktion des Darms) kann nur eine thematisch eng begrenzte Auswahl zur Darstellung der heute für klinisch relevant erachteten Probleme herangezogen werden.
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Literatur
Abe M, Takahashi M (1981) Intraoperative radiotherapy: The Japanese experience. Int J Radiat Oncol Biol Phys 7: 863–868
Archambeau J, Griem M, Harper P (1966) The effects of 250 kV X-rays on the dog’s pancreas: morphological and functional changes. Radiat Res 28: 243–256
Battermann JJ, Hart GAM, Breur K (1981) Dose-effect relations for tumour control and complication rate after fast neutron therapy for pelvic tumours. Br J Radiol 54: 899–904
Berthrong M, Fajardo LF (1981) Radiation injury in surgical pathology, II, Alimentary tract. Am J Surg Pathol 5: 153–178
Bicher HI, Ashbrook DW, Harris DR, Dalrymple GV (1976) Changes in platelet and microcirculation function induced by ionizing radiation to the liver. Int J Radiat Oncol Biol Phys 1: 679–685
Birzle H, Franzius E (1965) Über die funktionelle Strahlenempfindlichkeit der Leber. Strahlentherapie 126: 119–131
Birzle H, Beck K, Nusselt L (1970) Die Wirkung gezielter Röntgentiefenbestrahlung der Leber auf deren Entgiftungsleistung durch Paarung mit Glucuronsäure beim Kaninchen. Strahlentherapie 139: 347–353
Black WC, Ackermann LV (1965) Carcinoma of the large intestine as a late complication of pelvic radiotherapy. Clin Radiol 16: 278–281
Black WC, Gomez LS, Yuhas JM, Kligermann MM (1980) Quantitation of the late effects of X-radiation on the large intestine. Cancer 45: 444–451
Bowers RF, Brick JB (1947) Surgery in radiation in injury of the stomach. Surgery 22: 20–40
Brase A, Bockslaff H, Kaufmann M (1972) Szintigra-phische Befunde der Leber nach Teilbestrahlung mit Kobalt 60. Strahlentherapie 143: 41–47
Brase A, Bockslaff H, Heindl H, Järivinen S (1973) Tierexperimentelle Funktionsuntersuchungen mit Radionukliden an der Leber nach gezielter Co-60 Bestrahlung. Strahlentherapie 146: 198–207
Brase A, Bockslaff H, Emminger E (1974) Angiographische Untersuchungen der portalen LebergefäBe bei Kaninchen nach Strahleninsult. Strahlentherapie 147: 278–289
Braun H (1963) Leber. In: Scherer E, Stender HS (Hrsg) Strahlenpathologie der Zelle. Thieme, Stuttgart
Brick IB (1947) The effect of large dosages of irradia- tion gastric acidity. N Engl J Med 237: 48–51
Browde S, Mohr N de (1982) Non-standard fractionation schemes in the treatment of advanced carcinoma of the uterine cervix and advanced head and neck cancer. In: Nervi C, Fletcher GH (eds) The biological and clinical basis of radioresistance. Thomas, Springfield
Bruegel C (1917) Die Beeinflussung des Magenchemismus durch Röntgenstrahlen. Muench Med Wochenschr 64: 379–382
Carpender JWJ, Levin E, Clapman LB, Miller RE (1956) Radiation in the therapy of peptic ulcer. Am J Roentgenol 75: 374–379
Chen KY, Withers HR (1972) Survival characteristics of stem cells of gastric mucosa subjected to localized gamma irradiation. Int J Radiat Biol 21: 521–534
Coggle JE (1968) Effect of cell cycle on recovery from radiation damage in the mouse liver. Nature 217: 180–182
Concannon JP, Edelmann A, Rich JC, Kunkel G (1967) Localized “radiation hepatitis” as demonstrated by scintillation scanning. Radiology 89: 136–139
Cottier H (1961) Strahlenbedingte Lebensverkür- zung. Springer, Berlin Heidelberg New York
Craig MS, Buie LA (1949) Factitial (irradiation) proctitis. A clinicopathological study of 200 cases. Surgery 25: 472–487
Cronkite EP, Fliedner TM (1972) The radiation syndromes. In: Hug O, Zuppinger A (Hrsg) Strahlenbiologie 3. Springer, Berlin Heidelberg New York, S (Handbuch der Medizinischen Radiologie, Bd II/3
Delclos L, Braun EJ, Herrera JR, Sanpiere VC, Rosenbeek E van (1963) Whole abdominal irradiation with Co-60 moving strip technic. Radiology 81: 632–641
Dethlefsen LA, Riley RM (1979) The effects of adriamycin and X-irradiation on the murine duodenum. Int J Radiat Oncol 5: 507–513
Dettmer CA, Kramer S, Driscoll DH, Aponte GE (1968) A comparison of the chronic effects of irradiation upon the normal, damaged, and regenerating rat liver. Radiology 91: 993–997
Doig RK, Funder JF, Weiden S (1951) Serial gastric biopsy studies in a case of duodenal ulcer treated by deep X-ray therapy. Med J Aust 38: 828–830
Duncan W, Leonard JC (1965) The malabsorption syndrome following radiotherapy. QJ Med 34: 319–329
Edwards DN (1968) Complications following mega-voltage radiation for carcinoma of the bladder. Clin Radiol 19: 27–33
Ellinger F (1957) Medical radiation biology, Thomas, Springfield
Engelstad RB (1938) The effect of roentgen on the stomach in rabbits. Am J Roentgenol 40: 243–263
Fabrikant JI (1967) Cell proliferation in the regenerating liver of continuously irradiated mice. Br J Radiol 40: 487–495
Fajardo LF, Berthrong M (1981) Radiation injury in surgical pathology, III, Am J Surg Pathol 5: 279–296
Findley JM, Newaisky GA, Sircus W, McManus JPA (1974) Role of gastric irradiation in management of peptic ulceration and esophagitis. Br Med J 3: 769–771
Gauwerky F (1949) Die Komplikationen bei der Radiumbehandlung der Kollumkarzinome and ihre Bedeutung für den Behandlungserfolg. Strahlentherapie 80: 51–70
Gelfand MD, Tepper M, Katz LA, Binder HJ, Yesner R, Floch MH (1968) Acute irradiation proctitis in man. Development of eosinophilic crypt abcesses. Gastroenterology 54: 401–411
Geraci JP, Jackson KL, Christensen GM, Parker RG, Fox MS, Thrower PD (1974) The relative biological effectiveness of cyclotron fast neutrons for early and late damage to the small intestine of the mouse. Eur J Cancer 10: 99–102
Geraci JP, Jackson KL, Christensen GM, Thrower PD, Weyer BJ (1977) Acute and late damage in the mouse small intestine following multiple fractionations of neutrons or X-rays. Int J Radiat Oncol Biol Phys 2: 693–696
Geraci JP, Jackson KL, Thrower PD, Mariano MS (1980) Relative biological effectiveness of cyclotron fast neutrons for late hepatic injury in rats. Radiat Res 82: 570–578
Goldgraber MB, Rubin CE, Palmer WL, Dobson RL, Massey BW (1954) The early gastric response to irradiation. A serial biopsy study. Gastroenterology 27: 1–20
Goodrich JK, Hickmann BT (1962) Oleic acid I131 intestinal absorption in pelvic CO“ irradiation. Am J Roentgenol 87: 69–75
Graudinns J (1969) Über Strahlenspätschäden am Dünndarm. Langenbecks Arch Chir 324: 120–130
Gray MJ, Kottmeier HL (1957) Rectal and bladder injuries following radium therapy for carcinoma of the cervix at the radiumhemmet. Am J Obstet Gynecol 74: 1294–1303
Hamilton E (1978) Cell proliferation and ageing in mouse colon. Repopulation after repeated X-ray injury in young and old mice. Cell Tiss Kinet 11: 423–431
Hamilton FE (1947) Gastric ulcer following radiation. Arch Surg 55: 394–399
Haot J (1965) Contribution à l’étude de l’ulcere radiologique de l’estomac. Rev Belg Pathol Med Exp 31: 203–225
Hebard DW, Jackson KL, Christensen GM (1980) The chronological development of late radiation injury in the liver of the rat. Radiat Res 81: 441–454
Heyde W, Schmermund HJ (1953) Zur Vermeidung von Darmschäden bei der intravaginalen Bestrahlung des Kollumkarzinoms. Geburtshilfe Frauenhkd 13: 392–401
Hornsey S, Alper T (1966) Unexpected dose-rate effect in the killing of mice by radiation. Nature 210: 212–213
Hubmann FH (1981) Effect of X-irradiation on the rectum of the rat. Br J Radiol 54: 250–254
Hueper WC, Carvajal-Forero J de (1944) The effect of repeated irradiation of the gastric region with small doses of Roentgen rays upon the stomach and blood of dogs. Am J Roentgenol 52: 529–534
Hug O, Kellerer AM, Zuppinger A (1966) Der Zeitfaktor. In: Handbuch der medizinischen Radiologie, Bd II/1. In: Zuppinger A (Hrsg) Strahlenbiologie 1. Springer, Berlin Heidelberg New York, S 271–354
Ingold JA, Reed GB, Kaplan HS, Bagshaw MA (1965) Radiation Hepatitis. Am J Roentgenol 93: 200–208
Johnson PM, Grossman FM, Atkins HL (1967) Radiation induced hepatic injury, its detection by scintillation scanning. Am Roentgenol 99: 453–462
Kelly LS, Hirsch JD, Beach G, Palmer W (1956) The time function of P32 incorporation into DNA of regenerating liver; the effect of irradiation. Cancer Res 16: 117–121
Kinzie J, Studer RK, Perez B, Potchen EJ (1972) Noncytokinetic radiation injury: anticoagulants as radioprotective agents in experimental radiation hepatitis. Science 175: 1481–1483
Kiszel Z (1983) Untersuchungen über die chronischen Strahlenfolgen am Enddarm der Ratte nach lokaler Bestrahlung. Dissertation medizinische Fakultät, Universität München
Kolb JJ (1982) Knochenmarkstransplantation: Theoretische Grundlagen, vorklinische Studien und klinische Anwendung. Habilitationsarbeit, Medizinische Fakultät der Universität München
Kolb JJ, Rieder I, Bodenberger B, Netzel B, Schaffer E, Kolb H, Thierfelder S (1979) Dose rate and dose fractionation studies in total body irradiation of dogs. Pathol Biol (Paris) 27: 370–372
Kottmeier HL, Gray MJ (1961) Rectal and bladder injuries in relation to radiation dosage in carcinoma of the cervix. A 5 year follow-up. Am J Obstet Gynecol 82: 74–82
Kovacs L (1976) Histologische Untersuchungen von Pankreasveränderungen verursacht durch experimentelle, fraktionierte, lokale Bestrahlung. Strahlentherapie 152: 455–468
Kurohara SS, Swensson NL, Usselmann JA, George FW (1967) Response and recovery of liver to radiation as demonstrated by photoscan. Radiology 89: 129–135
Lenk R (1926) Die Röntgentherapie der Erkrankungen des Verdauungstraktes. In: Meyer H (Hrsg) Lehrbuch der Strahlentherapie, Bd III. Urban Schwarzenberg, Berlin Wien, S 451–486
Lewin K, Millis RR (1973) Human radiation hepatitis. A morphologic study with emphasis on the late changes. Arch Pathol 96: 21–26
Marciàl VA, Santiago EA, Lanaro EA, Castro-Vita H, Arroyo G, Moscol JA, Gomez C, Velasquez J, Prado K (1977) Radiation-induced liver damage. In: Radiobiological research and radiotherapy, vol II. International Atomic Agency, Wien
Matsuzawa T, Wilson R (1965) The intestinal mucosa of germfree mice after whole body X-irradiation with 3 kiloroentgens. Radiat Res 25: 15–24
Morgenstern L, Thompson R, Friedman NB (1977) The modern enigma of radiation enteropathy: sequelae and solutions. Am J Surg 134: 166–172
Neumeister K (1973) Die Strahlenreaktionen des Gastrointestinaltraktes. Thieme, Leipzig
Ogata K, Hizawa K, Yoshida M, Kitamuro T, Akagi G, Kagawa K, Fukuda F (1963) Hepatic injury following irradiation — a morphologic study. Tokushima Journal of experimental Medicine 9: 240–251
Palmer WL, Templeton F (1939) The effect of radiation therapy on gastric secretion. JAMA 112: 1429–1434
Phillips TL (1980) Tissue toxicity of Radiation-Drug Interactions. In: Sokol GH, Maickel RP (eds) Radiation-Drug Interactions in the treatment of cancer. Wiley, New York Chichester Brisbane Toronto
Phillips TL, Fu KK (1976) Quantification of combined radiation therapy and chemotherapy effects on critical normal tissues. Cancer 37: 1186–1200
Powel-Smith C (1965) Factors influencing the incidence of radiation injury in cancer of the cervix. J Ass Canad Radiol 16: 132–137
Quastler H (1956) The nature of intestinal radiation death. Radiat Res 4: 303–320
Reed GB, Cox AJ (1966) The human liver after radiation injury. Am J Pathol 48: 597–611
Reeves RJ, Cavanaugh PJ, Sharpe KW, Thorne WA, Winkler C, Sanders AP (1959) Fat absorption from human gastrointestinal tract in patients undergoing radiation therapy. Radiology 73: 398–401
Reeves RJ, Sanders AP, Isley JK, Sharpe KW, Baylin GJ (1965) Fat absorption studies and small bowel X-Ray studies in patients undergoing Co“ teletherapy and or radium application. Am J Roentgenol 94: 848–851
Ricketts WE, Palmer WL, Kirner JB, Hamann A (1948) Radiation therapy in peptic ulcer. An analysis of results. Gastroenterology 11: 789–806
Roswit B, Malsky SJ, Reid CB (1972) Radiation tolerance of the gastrointestinal tract. Front Radiat Ther Oncol 6: 160–181
Rübe W, Seegelken K (1974) Dickdarmstenosen nach Bestrahlung von Nierentumoren. Strahlentherapie 147: 63–68
Rubin P, Casarett GW (1968) Clinical radiation pathology. Saunders, Philadelphia London Toronto
Schenken LL, Burholt DR, Hagemann RF, Lesher S (1976) The modification of gastrointestinal tolerance and responses to abdominal irradiation by chemotherapeutic agents. Radiology 120: 417–420
Senn A, Lundsgard-Hansen P (1956) Diagnose und Therapie der Bestrahlungsschäden am Gastroin-testinaltrakt. Schweiz Med Wochenschr 86: 1015–1020
Singh K (1978) Two regimes with the same TDF but differing morbidity used in the treatment of stage III carcinoma of the cervix. Br J Radiol 51: 357–362
Swift MN, Taketa ST, Bond VP (1955) Delayed gastric emtying in rats after whole and partial body irradiation. Am J Physiol 182:479-
Takahashi T (1964) A study on preoperative and postoperative telecobalt therapy in gastric cancer. Three year results of Co“ irradiation following palliative gastric resection. Nippon Acta Radiol 24: 129–132
Tefft M, Mitus A, Das L, Vawter GF, Filler RM (1970) Irradiation of the liver in children: review of experience in the acute and chronic phases, and in the intact normal and partially resected. Am J Roentgenol 108: 365–385
Thames HD, Withers HR, Peters LJ, Fletcher GH (1982) Changes in early and late radiation responses with dose fractionation. Implications for dose-survival relationships. Int J Radiat Oncol 8: 219–222
Usselman JA (1965) Liver scanning in the assessment of liver damage from therapeutic external irradiation. J Nucl Med 6: 353–364
Warren SH, Friedman NP (1942) Pathology and pathological diagnosis of radiation lesions in the gastrointestinal tract. Am J Pathol 18: 499
Wharton JT, Delclos L, Gallager S, Smith JP (1973) Radiation hepatitis induced by abdominal irradiation with the cobalt-60 moving strip technique. Am J Roentgenol 117: 73–80
Wiernik G, Plant M (1970) Radiation effects on the human intestinal mucosa. Curr Top Radiat Res 7:327–368
Wiley HM, Sugarbaker ED (1950) Roentgenotherapeutic changes in the small intestine. Surgical aspects. Cancer 3: 629–640
Withers HR, Elkind MM (1968) Radiosensitivity and fractionation response of crypt cells of mouse jejunum. Radiat Res 38: 598–613
Withers HR, Elkind MM (1970) Microcolony survival assay for cells of mouse intestinal mucosa exposed to radiation. Int J Radiat Biol 17: 261–267
Withers HR, Mason KA (1974) The kinetics recovery in irradiated colonic mucosa of the mouse. Cancer 34: 896–904
Zollinger HU (1960) Radiohistologie und Radiohistopathologie. In: Roulet F (Hrsg) Strahlung und Wetter. Handbuch der Pathologie, Bd X/1. Springer, Berlin Heidelberg New York, S 127
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Trott, KR. (1985). Strahlenwirkungen auf die Abdominalorgane. In: Heuck, F., Scherer, E. (eds) Strahlengefahrdung und Strahlenschutz / Radiation Exposure and Radiation Protection. Handbuch der Medizinischen Radiologie / Encyclopedia of Medical Radiology, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82229-2_3
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