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Estrogen Receptor Analysis on Fine Needle Aspirates from Human Breast Carcinoma

  • C. Silfverswärd
  • A. Wallgren
  • B. Nordenskjöld
  • S. Humla
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 91)

Abstract

The concentration of estrogen receptor protein (ER) in breast carcinoma is a useful indicator of the likelihood of response to endocrine therapy [3]. A correlation between low receptor values and early recurrence of the carcinoma has also been shown [7]. In most centers the ER analysis is performed on surgically removed tumor specimens. However, in many patients with inoperable or recurrent carcinoma, surgical specimens for ER determinations are not readily available, and after preoperative irradiation ER determination is unreliable as the primary tumor often undergoes advanced degenerative changes or totally disappears [6]. In such cases ER determination on fine needle aspirates could be a method of choice. Two earlier reports based on a small number of patients [4, 5] indicated that reproducible ER levels may be obtained from analysis of fine needle aspirates from breast carcinoma. The present study of 168 patients examines the results of ER analysis on fine needle aspirates collected from patients with primary or recurrent breast carcinoma prior to surgery. For comparison, analysis was also performed on histologic tissue material after surgical biopsy or mastectomy.

Keywords

Estrogen Receptor Breast Carcinoma Fine Needle Aspirate Karolinska Hospital Human Mammary Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1984

Authors and Affiliations

  • C. Silfverswärd
    • 1
    • 2
    • 3
  • A. Wallgren
    • 1
    • 2
    • 3
  • B. Nordenskjöld
    • 1
    • 2
    • 3
  • S. Humla
    • 1
    • 2
    • 3
  1. 1.Department of Tumor PathologyKarolinska HospitalStockholmSweden
  2. 2.Department of OncologyKarolinska HospitalStockholmSweden
  3. 3.Department of OncologyRegionssjukhusetLinköpingSweden

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