Interlaboratory Variability in the Determination of Estrogen Receptor and Progesterone Receptor Content in Human Breast Tumors: Quality Control in Switzerland

  • D. T. Zava
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 91)


Analysis of estrogen receptor (ER) and progesterone receptor (PgR) in breast tumor biopsies has become routine practice in many clinical laboratories, primarily for two reasons: first, to help the clinician select the most effective therapy for patients with breast cancer, and, second, to compare the hormone receptor status of patients’ tumors with other disease-related parameters. For such retrospective comparisons within large study groups contributing data to common trials to be meaningful, it is essential that the interlaboratory differences in receptor data gathering be reduced to a minimum. Quality control studies are therefore necessary to recognize and eliminate the differences in interlaboratory methodology in order to be able to statistically compare with confidence the hormone receptor data with other disease parameters.


Steroid Hormone Receptor Reference Laboratory Human Breast Tumor Quality Control Study Interlaboratory Variability 
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  1. 1.
    Scatchard G (1951) The attraction of proteins for small molecules and ions. Ann NY Acad Sci 51: 660–672CrossRefGoogle Scholar
  2. 2.
    Lowry DH, Rosenbrough WJ, Farr AL, Randall PJ (1961) Protein measurement with the folin phenol reagent. J Biol Chem 193: 265–275Google Scholar
  3. 3.
    Jordan VC, Zava DT, Eppenberger U, Kiser A, Sebek S, Dowdle, E, Krozowski Z, Bennett RC, Funder J, Holdaway IM, Wittliff JL (1983) Reliability of steroid hormone receptor assays: an international study. Eur J Cancer Clin Oncol 19: 357–363PubMedCrossRefGoogle Scholar
  4. 4.
    Raam S, Gelman R, Cohen JL, Bachrach A, Fishchinger AJ, Jacobson HI, Keshgegian AA, Konopka SJ, Wittliff JL (1981) Estrogen receptor assay: interlaboratory and intralaboratory variations in the measurement of receptors using dextran-coated charcoal technique: a study sponsored by ECOG Eur J Cancer 17: 643–649Google Scholar
  5. 5.
    King RJB (1980) Quality control of estradiol receptor analysis: the United Kingdom experience. Cancer 46: 2822–2824PubMedCrossRefGoogle Scholar
  6. 6.
    Zava DT, Wyler-von Ballmoos A, Goldhirsch A, Roos W, Takahashi A, Eppenberger U, Arrenbrecht S, Martz G, Losa G, Gomez F, Guelpa C (1983) A quality control study to assess the interlaboratory variability of routine estrogen and progesterone receptor assays. Eur J Cancer Oncol 18: 713–721CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1984

Authors and Affiliations

  • D. T. Zava
    • 1
  1. 1.Ludwig Institut für KrebsforschungInselspitalBernSwitzerland

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