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Interlaboratory Variability in the Determination of Estrogen Receptor and Progesterone Receptor Content in Human Breast Tumors: Quality Control in Switzerland

  • D. T. Zava
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 91)

Abstract

Analysis of estrogen receptor (ER) and progesterone receptor (PgR) in breast tumor biopsies has become routine practice in many clinical laboratories, primarily for two reasons: first, to help the clinician select the most effective therapy for patients with breast cancer, and, second, to compare the hormone receptor status of patients’ tumors with other disease-related parameters. For such retrospective comparisons within large study groups contributing data to common trials to be meaningful, it is essential that the interlaboratory differences in receptor data gathering be reduced to a minimum. Quality control studies are therefore necessary to recognize and eliminate the differences in interlaboratory methodology in order to be able to statistically compare with confidence the hormone receptor data with other disease parameters.

Keywords

Steroid Hormone Receptor Reference Laboratory Human Breast Tumor Quality Control Study Interlaboratory Variability 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1984

Authors and Affiliations

  • D. T. Zava
    • 1
  1. 1.Ludwig Institut für KrebsforschungInselspitalBernSwitzerland

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