Radiotherapy of Cancer Pain
The alleviation of cancer pain by ionizing radiation was observed early in the development of radiotherapy. In the first months of 1896 — on 28 December 1895 Roentgen had just presented his discovery of X-rays — Despeignes in Lyon reported a striking analgetic effect of X-ray therapy on a cancroid of the floor of the mouth and a stomach cancer and, at the end of 1896, Williams in Boston published a report of remarkable, fast regression of pain in a repeatedly operated patient with breast cancer (see Glasser 1958). Subsequently, the analgetic effect of ionizing radiation has also been utilized for a large number of benign diseases within the scope of the anti-inflammatory irradiation of acute and chronic processes inaugurated by Heidenhain and Fried in 1924. The effect has been explained by an influence on the autonomic nervous system, by electrolyte redistribution at the peripheral ends of the nerves, and a change of acidosis frequently present in the tissue toward neutral pH.
KeywordsBone Metastasis Cancer Pain Osteoblastic Metastasis Analgetic Effect Percutaneous Irradiation
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- Allen KL (1981) Rapid palliation in private practice. In: Weiss L, Gilbert HA (eds) Bone metastasis. Hall, Boston, pp 457–468Google Scholar
- Ambrad A (1981) Single-dose and short high-dose fractionation radiation therapy for osseous metastases. In: Weiss L, Gilbert HA (eds) Bone metastasis. Hall, Boston, pp 452–456Google Scholar
- Denoix P (1970) Treatment of malignant breast tumors. Springer, Berlin Heidelberg New York (Recent results in cancer research, vol 31 )Google Scholar
- Forrest APM, Stewart HJ (1967) Technical problems and results of yttrium hypophysectomy. In: Dargent M, Romieu C (eds) Major endocrine surgery for the treatment of cancer of the breast in advanced stages. Simap, Lyon, p 89Google Scholar
- Glasser O (1958) Wilhelm Conrad Röntgen und die Geschichte der Röntgenstrahlen. Springer, Berlin Göttingen HeidelbergGoogle Scholar
- Kutzner J, Dähmert W, Schreyer T, Grimm W, Brod KH, Becker M (1981) Yttrium-90 zur Schmerztherapie von Knochenmetastasen. Nuclearmedizin 20: 229–235Google Scholar
- Schlegel G (1982) Die Therapie des Tumorschmerzes. Tumordiagnostik 3: 10–16Google Scholar
- Wizenberg MJ (1981) The philosophy and economics of palliative radiotherapy for bone metastases. In: Weiss L, Gilbert HA (eds) Bone metastasis. Hall, Boston, pp 390–398Google Scholar