Intra-Arterial Infusion of Bromodeoxyuridine and Radiotherapy in Osteosarcoma and Other Bone Malignancies

  • F. J. Lejeune
  • R. Regnier
  • J.-M. Nogaret
  • M. Jabri
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 86)

Abstract

Amputation of a limb does not seem to improve survival in osteosarcoma (Huvos 1979; Lejeune et al. 1972). About 80% of patients referred for primary osteosarcoma are expected to die, mostly of lung metastases, within 5 years (Prise and Jeffrey 1973). It is commonly accepted that most osteosarcoma metastases are present at the time of primary tumor diagnosis in the form of undetectable micrometastases. In recent years several adjuvant regimens of chemotherapy have been proposed for treating lung micrometastases, mainly using high doses of methotrexate and adriamycin (Huvos 1979). Accordingly, the extent of the surgical procedure has been reduced, especially for primary limb tumors, without diminishing local control of the tumor (Rosen et al. 1976).

Keywords

Permeability Toxicity Catheter Heparin Oncol 

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1983

Authors and Affiliations

  • F. J. Lejeune
    • 1
  • R. Regnier
    • 1
  • J.-M. Nogaret
    • 1
  • M. Jabri
    • 1
  1. 1.Service de ChirurgieInstitut Jules Bordet, Centre des Tumeurs de l’Université Libre de BruxellesBruxellesBelgium

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