Intra-Arterial Infusion of Bromodeoxyuridine and Radiotherapy in Osteosarcoma and Other Bone Malignancies
Amputation of a limb does not seem to improve survival in osteosarcoma (Huvos 1979; Lejeune et al. 1972). About 80% of patients referred for primary osteosarcoma are expected to die, mostly of lung metastases, within 5 years (Prise and Jeffrey 1973). It is commonly accepted that most osteosarcoma metastases are present at the time of primary tumor diagnosis in the form of undetectable micrometastases. In recent years several adjuvant regimens of chemotherapy have been proposed for treating lung micrometastases, mainly using high doses of methotrexate and adriamycin (Huvos 1979). Accordingly, the extent of the surgical procedure has been reduced, especially for primary limb tumors, without diminishing local control of the tumor (Rosen et al. 1976).
KeywordsPermeability Toxicity Catheter Heparin Oncol
Unable to display preview. Download preview PDF.
- Ballaux JM, Schils C, Frühling J, Osteaux M, Heimann R, Lejeune FJ (1980) Diagnosis of bone tumours by arteriography-guided drill biopsy. Turn Diagn 2: 96–100Google Scholar
- Dahlin DC, Coventry MB (1967) Osteogenic sarcoma. A study of 600 cases. J Bone Joint Surg [Am] 49: 101–110Google Scholar
- Huvos AG (1979) Bone tumors. Diagnosis, treatment and prognosis. Saunders, PhiladelphiaGoogle Scholar